Matches in SemOpenAlex for { <https://semopenalex.org/work/W3195048906> ?p ?o ?g. }
- W3195048906 abstract "Abstract Maturation rate of malaria parasites within red blood cells (RBC) can be influenced by host nutrient status or circadian rhythm. Here, we observed in mice that systemic host inflammation, induced by lipopolysaccharide (LPS) conditioning or ongoing acute malaria infection, slowed the progression of a single cohort of parasites from one generation of RBC to the next. LPS-conditioning and acute infection both triggered substantial changes to the metabolomic composition of plasma in which parasites circulated. This altered plasma directly slowed parasite maturation in a manner that could not be rescued by supplementation, consistent with the presence of inhibitory factors. Single-cell transcriptomic assessment of mixed parasite populations, exposed to a short period of systemic host inflammation in vivo , revealed specific impairment in the transcriptional activity and translational capacity of trophozoites compared to rings or schizonts. Thus, we provide in vivo evidence of transcriptomic and phenotypic plasticity of asexual blood-stage Plasmodium parasites when exposed to systemic host inflammation." @default.
- W3195048906 created "2021-08-30" @default.
- W3195048906 creator A5005735271 @default.
- W3195048906 creator A5008694243 @default.
- W3195048906 creator A5009240719 @default.
- W3195048906 creator A5010374020 @default.
- W3195048906 creator A5017617402 @default.
- W3195048906 creator A5021284354 @default.
- W3195048906 creator A5030467692 @default.
- W3195048906 creator A5032696857 @default.
- W3195048906 creator A5039753508 @default.
- W3195048906 creator A5047499201 @default.
- W3195048906 creator A5048525962 @default.
- W3195048906 creator A5050252355 @default.
- W3195048906 creator A5053330477 @default.
- W3195048906 creator A5070211234 @default.
- W3195048906 creator A5070498464 @default.
- W3195048906 creator A5081409594 @default.
- W3195048906 creator A5083735844 @default.
- W3195048906 date "2021-08-19" @default.
- W3195048906 modified "2023-09-27" @default.
- W3195048906 title "Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites" @default.
- W3195048906 cites W2069089843 @default.
- W3195048906 cites W2087041435 @default.
- W3195048906 cites W2099767800 @default.
- W3195048906 cites W2105136979 @default.
- W3195048906 cites W2116860816 @default.
- W3195048906 cites W2122534122 @default.
- W3195048906 cites W2142945482 @default.
- W3195048906 cites W2156686268 @default.
- W3195048906 cites W2169431889 @default.
- W3195048906 cites W2337851444 @default.
- W3195048906 cites W2399376286 @default.
- W3195048906 cites W2725507533 @default.
- W3195048906 cites W2731543976 @default.
- W3195048906 cites W2750962203 @default.
- W3195048906 cites W2766874071 @default.
- W3195048906 cites W2768045943 @default.
- W3195048906 cites W2799909812 @default.
- W3195048906 cites W2889276550 @default.
- W3195048906 cites W2901677030 @default.
- W3195048906 cites W2902652978 @default.
- W3195048906 cites W2917240375 @default.
- W3195048906 cites W2922805334 @default.
- W3195048906 cites W2969974048 @default.
- W3195048906 cites W2997280954 @default.
- W3195048906 cites W3025962581 @default.
- W3195048906 cites W3028833085 @default.
- W3195048906 cites W3091910761 @default.
- W3195048906 cites W3094458800 @default.
- W3195048906 cites W4244845329 @default.
- W3195048906 doi "https://doi.org/10.1101/2021.08.18.456784" @default.
- W3195048906 hasPublicationYear "2021" @default.
- W3195048906 type Work @default.
- W3195048906 sameAs 3195048906 @default.
- W3195048906 citedByCount "0" @default.
- W3195048906 crossrefType "posted-content" @default.
- W3195048906 hasAuthorship W3195048906A5005735271 @default.
- W3195048906 hasAuthorship W3195048906A5008694243 @default.
- W3195048906 hasAuthorship W3195048906A5009240719 @default.
- W3195048906 hasAuthorship W3195048906A5010374020 @default.
- W3195048906 hasAuthorship W3195048906A5017617402 @default.
- W3195048906 hasAuthorship W3195048906A5021284354 @default.
- W3195048906 hasAuthorship W3195048906A5030467692 @default.
- W3195048906 hasAuthorship W3195048906A5032696857 @default.
- W3195048906 hasAuthorship W3195048906A5039753508 @default.
- W3195048906 hasAuthorship W3195048906A5047499201 @default.
- W3195048906 hasAuthorship W3195048906A5048525962 @default.
- W3195048906 hasAuthorship W3195048906A5050252355 @default.
- W3195048906 hasAuthorship W3195048906A5053330477 @default.
- W3195048906 hasAuthorship W3195048906A5070211234 @default.
- W3195048906 hasAuthorship W3195048906A5070498464 @default.
- W3195048906 hasAuthorship W3195048906A5081409594 @default.
- W3195048906 hasAuthorship W3195048906A5083735844 @default.
- W3195048906 hasBestOaLocation W31950489061 @default.
- W3195048906 hasConcept C104317684 @default.
- W3195048906 hasConcept C126831891 @default.
- W3195048906 hasConcept C136449434 @default.
- W3195048906 hasConcept C136764020 @default.
- W3195048906 hasConcept C150194340 @default.
- W3195048906 hasConcept C162317418 @default.
- W3195048906 hasConcept C203014093 @default.
- W3195048906 hasConcept C207001950 @default.
- W3195048906 hasConcept C2776252253 @default.
- W3195048906 hasConcept C2776914184 @default.
- W3195048906 hasConcept C2778048844 @default.
- W3195048906 hasConcept C2778371730 @default.
- W3195048906 hasConcept C2778675580 @default.
- W3195048906 hasConcept C2778754761 @default.
- W3195048906 hasConcept C2779341262 @default.
- W3195048906 hasConcept C41008148 @default.
- W3195048906 hasConcept C54355233 @default.
- W3195048906 hasConcept C71928629 @default.
- W3195048906 hasConcept C86803240 @default.
- W3195048906 hasConcept C8891405 @default.
- W3195048906 hasConcept C95444343 @default.
- W3195048906 hasConceptScore W3195048906C104317684 @default.
- W3195048906 hasConceptScore W3195048906C126831891 @default.
- W3195048906 hasConceptScore W3195048906C136449434 @default.
- W3195048906 hasConceptScore W3195048906C136764020 @default.