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- W3195118766 abstract "Utilizing kidneys from donors with hepatitis B is one way to alleviate the current organ shortage situation. However, the risk of hepatitis B virus (HBV) transmission remains a challenge that undermines the chance of organs being used. This is particularly true with hepatitis B surface antigen (HBsAg) positive donors despite the comparable long-term outcomes when compared with standard donors. To reduce the risk of HBV transmission, a comprehensive approach is needed. This includes assessment of donor risk, optimal allocation to the proper recipient, appropriate immunosuppressive regimen, optimizing the prophylactic therapy, and post-transplant monitoring. This review provides an overview of current evidence of kidney transplants from donors with HBsAg positivity and outlines the challenge of this treatment. The topics include donor risk assessment by adopting the nucleic acid test coupled with HBV DNA as the HBV screening, optimal recipient selection, importance of hepatitis B immunity, role of nucleos(t)ide analogues, and hepatitis B immunoglobulin. A summary of reported long-term outcomes after kidney transplantation and proposed criteria to utilize kidneys from this group of donors was also defined and discussed." @default.
- W3195118766 created "2021-08-30" @default.
- W3195118766 creator A5034450943 @default.
- W3195118766 creator A5086346838 @default.
- W3195118766 date "2021-08-27" @default.
- W3195118766 modified "2023-09-27" @default.
- W3195118766 title "Kidney transplant from donors with hepatitis B: A challenging treatment option" @default.
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- W3195118766 doi "https://doi.org/10.4254/wjh.v13.i8.853" @default.
- W3195118766 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8422915" @default.
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- W3195118766 hasPublicationYear "2021" @default.
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