FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3195162008> ?p ?o ?g. }

• W3195162008 endingPage "1226" @default.
• W3195162008 startingPage "1226" @default.
• W3195162008 abstract "The risk of malignant brain tumors associated with metformin use has rarely been investigated in humans. This retrospective cohort study investigated such an association. Patients with new-onset type 2 diabetes mellitus diagnosed from 1999 to 2005 in the nationwide database of Taiwan's national health insurance were used to enroll study subjects. We first identified an unmatched cohort of 153,429 ever users and 16,222 never users of metformin. A cohort of 16,222 ever users and 16,222 never users matched on propensity score was then created from this unmatched cohort. All patients were followed up from 1 January 2006 until 31 December 2011. The incidence density was calculated and hazard ratios were derived from Cox regression incorporated with the inverse probability of treatment weighting using a propensity score. The results showed that 27 never users and 155 ever users developed malignant brain tumors in the unmatched cohort. The incidence rate was 37.11 per 100,000 person-years in never users and 21.39 per 100,000 person-years in ever users. The overall hazard ratio comparing ever users versus never users was 0.574 (95% confidence interval: 0.381-0.863). The respective hazard ratios comparing the first (<27.13 months), second (27.13-58.33 months), and third (>58.33 months) tertiles of cumulative duration of metformin therapy versus never users were 0.897 (0.567-1.421), 0.623 (0.395-0.984), and 0.316 (0.192-0.518). In the matched cohort, the overall hazard ratio was 0.317 (0.149-0.673) and the respective hazard ratios were 0.427 (0.129-1.412), 0.509 (0.196-1.322), and 0.087 (0.012-0.639) for the first, second, and third tertile of cumulative duration of metformin therapy. In conclusion, this study shows a risk reduction of malignant brain tumors associated with metformin use in a dose-response pattern. The risk reduction is more remarkable when metformin has been used for approximately 2-5 years." @default.
• W3195162008 created "2021-08-30" @default.
• W3195162008 creator A5038889667 @default.
• W3195162008 date "2021-08-17" @default.
• W3195162008 modified "2023-10-16" @default.
• W3195162008 title "Metformin and Risk of Malignant Brain Tumors in Patients with Type 2 Diabetes Mellitus" @default.
• W3195162008 cites W1859319201 @default.
• W3195162008 cites W1901450410 @default.
• W3195162008 cites W1976993918 @default.
• W3195162008 cites W1979100644 @default.
• W3195162008 cites W1987296211 @default.
• W3195162008 cites W1995090069 @default.
• W3195162008 cites W2021692067 @default.
• W3195162008 cites W2026811442 @default.
• W3195162008 cites W2052543023 @default.
• W3195162008 cites W2068341308 @default.
• W3195162008 cites W2103371988 @default.
• W3195162008 cites W2110818436 @default.
• W3195162008 cites W2116053582 @default.
• W3195162008 cites W2117692326 @default.
• W3195162008 cites W2118107482 @default.
• W3195162008 cites W2128584370 @default.
• W3195162008 cites W2130511906 @default.
• W3195162008 cites W2139611060 @default.
• W3195162008 cites W2148977460 @default.
• W3195162008 cites W2155011315 @default.
• W3195162008 cites W2164553361 @default.
• W3195162008 cites W2165806288 @default.
• W3195162008 cites W2173688745 @default.
• W3195162008 cites W2289621013 @default.
• W3195162008 cites W2349401071 @default.
• W3195162008 cites W2366536035 @default.
• W3195162008 cites W2501324976 @default.
• W3195162008 cites W2509157457 @default.
• W3195162008 cites W2509581545 @default.
• W3195162008 cites W2551506677 @default.
• W3195162008 cites W2552674175 @default.
• W3195162008 cites W2559968683 @default.
• W3195162008 cites W2607134143 @default.
• W3195162008 cites W2607455204 @default.
• W3195162008 cites W2607640564 @default.
• W3195162008 cites W2624516058 @default.
• W3195162008 cites W2743010525 @default.
• W3195162008 cites W2752477652 @default.
• W3195162008 cites W2772156705 @default.
• W3195162008 cites W2791129175 @default.
• W3195162008 cites W2801233527 @default.
• W3195162008 cites W2804622202 @default.
• W3195162008 cites W2809909380 @default.
• W3195162008 cites W2810882190 @default.
• W3195162008 cites W2889742234 @default.
• W3195162008 cites W2890881595 @default.
• W3195162008 cites W2891837442 @default.
• W3195162008 cites W2903734772 @default.
• W3195162008 cites W2932777621 @default.
• W3195162008 cites W2946268863 @default.
• W3195162008 cites W2954019687 @default.
• W3195162008 cites W2955350681 @default.
• W3195162008 cites W2961422708 @default.
• W3195162008 cites W2962999808 @default.
• W3195162008 cites W2980864243 @default.
• W3195162008 cites W2996600412 @default.
• W3195162008 cites W3028240331 @default.
• W3195162008 cites W30336109 @default.
• W3195162008 cites W3038371998 @default.
• W3195162008 cites W3094950872 @default.
• W3195162008 cites W3110510915 @default.
• W3195162008 cites W3113052480 @default.
• W3195162008 cites W3113162609 @default.
• W3195162008 cites W3121017260 @default.
• W3195162008 cites W3123073211 @default.
• W3195162008 cites W3124475844 @default.
• W3195162008 cites W3128706037 @default.
• W3195162008 cites W3129483513 @default.
• W3195162008 cites W3130352257 @default.
• W3195162008 cites W3132508197 @default.
• W3195162008 cites W3132555342 @default.
• W3195162008 cites W3153662722 @default.
• W3195162008 cites W3160132471 @default.
• W3195162008 cites W3167369705 @default.
• W3195162008 cites W3168593611 @default.
• W3195162008 cites W3173722264 @default.
• W3195162008 cites W3174246647 @default.
• W3195162008 cites W3176391058 @default.
• W3195162008 cites W4211132876 @default.
• W3195162008 cites W4245892763 @default.
• W3195162008 cites W2939306331 @default.
• W3195162008 doi "https://doi.org/10.3390/biom11081226" @default.
• W3195162008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8391370" @default.
• W3195162008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34439890" @default.
• W3195162008 hasPublicationYear "2021" @default.
• W3195162008 type Work @default.
• W3195162008 sameAs 3195162008 @default.
• W3195162008 citedByCount "6" @default.
• W3195162008 countsByYear W31951620082021 @default.
• W3195162008 countsByYear W31951620082022 @default.
• W3195162008 countsByYear W31951620082023 @default.
• W3195162008 crossrefType "journal-article" @default.

• next