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• W3195277739 abstract "Sudden cardiac death (SCD) related to postmyocardial infarction (post-MI) occurs under conditions of ectopic triggers, substrate of reentrant ventricular tachycardia (VT), and ventricular fibrillation (VF). Frequent premature ventricular complexes (PVCs) in post-MI patients are indicators of poorer prognosis. 1 Ruberman W. Weinblatt E. Goldberg J.D. Frank C.W. Shapiro S. Ventricular premature beats and mortality after myocardial infarction. N Engl J Med. 1977; 297: 750-757 Crossref PubMed Scopus (487) Google Scholar Frequent PVCs reduce left ventricular (LV) contractility because of mechanical dyssynchronous contraction, irregular R-R interval, and changes in the autonomic nerve system, which exacerbate heart failure and sometimes cause SCD. 2 Huizar J.F. Kaszala K. Potfay J. et al. Left ventricular systolic dysfunction induced by ventricular ectopy: a novel model for premature ventricular contraction-induced cardiomyopathy. Circ Arrhythm Electrophysiol. 2011; 4: 543-549 Crossref PubMed Scopus (106) Google Scholar Over the past 2 decades, an increasing amount of evidence has accumulated with regard to the beneficial role of catheter ablation targeting frequent PVCs on cardiac function in patients with LV dysfunction due to post-MI or other nonischemic cardiomyopathies. 3 Yokokawa M. Good E. Crawford T. et al. Recovery from left ventricular dysfunction after ablation of frequent premature ventricular complexes. Heart Rhythm. 2013; 10: 172-175 Abstract Full Text Full Text PDF PubMed Scopus (118) Google Scholar ,4 Zang M. Zhang T. Mao J. Zhou S. He B. Beneficial effects of catheter ablation of frequent premature ventricular complexes on left ventricular function. Heart. 2014; 100: 787-793 Crossref PubMed Scopus (46) Google Scholar A recent study demonstrated that PVCs in post-MI patients predominantly originated from the MI scar or LV outflow tract. 5 Penela D. Teres C. Fernandez-Armenta J. et al. Premature ventricular complex site of origin and ablation outcomes in patients with prior myocardial infarction. Heart Rhythm. 2021; 18: 27-33 Abstract Full Text Full Text PDF PubMed Scopus (5) Google Scholar Therefore, in patients with structural heart diseases in whom frequent PVCs are suspected to be contributing to cardiomyopathy and for whom antiarrhythmic drugs are ineffective, not tolerated, or not preferred for long-term therapy, catheter ablation is useful and recommended. 6 Cronin E.M. Bogun F.M. Maury P. et al. 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias: executive summary. J Arrhythm. 2020; 36: 1-58 Crossref PubMed Scopus (10) Google Scholar Discrete sites of frequent premature ventricular complexes cluster within the infarct border zone and coincide with high frequency of delayed afterdepolarizations under adrenergic stimulationHeart RhythmVol. 18Issue 11PreviewSympathetic activation in ischemic heart disease can cause lethal arrhythmias. These often are preceded by premature ventricular complexes (PVCs), which at the cellular level could result from delayed afterdepolarizations. Full-Text PDF Open Access" @default.
• W3195277739 created "2021-08-30" @default.
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• W3195277739 date "2021-08-01" @default.
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• W3195277739 title "Ischemia-induced premature ventricular complexes: Is it still complex?" @default.
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• W3195277739 doi "https://doi.org/10.1016/j.hrthm.2021.08.020" @default.
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