FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3195280212> ?p ?o ?g. }

• W3195280212 endingPage "535" @default.
• W3195280212 startingPage "527" @default.
• W3195280212 abstract "This study explored the molecular mechanism behind the protective effects from low-dose lipopolysaccharide (LPS) on an in-vitro model of spinal cord injury (SCI). For this, PC12 cells were treated with different concentrations of LPS and the cell counting kit-8 assay was used to measure the toxicity of LPS to the cells. Next, we used immunofluorescence to measure nuclear translocation of Nrf2 in PC12 cells. PC12 cells were then treated with IGF-1 (PI3K agonist) and LY294002 (PI3K inhibitor). An in-vitro model of SCI was then established via oxygen-glucose deprivation/reoxygenation. Rates of apoptosis were measured using flow cytometry and the TUNEL assay. Low-dose LPS increased the expression levels of Nrf2, p-PI3K/PI3K, and p-AKT/AKT, and facilitated nuclear translocation of Nrf2. The activation of PI3K-AKT signaling by IGF-1 significantly increased the expression of Nrf2, whereas inhibition of PI3K-AKT signaling significantly decreased the expression of Nrf2. Low-dose LPS reduced the apoptotic ratio of PC12 cells, decreased the expression levels of caspase 3 and caspase 9, and increased the expression levels of HO-1, NQO1, and γ-GCS. Low-dose LPS also reduced the rate of apoptosis and oxidative stress by activating the PI3K-AKT-Nrf2 signaling pathway. Collectively, the results indicate that PI3K-AKT-Nrf2 signaling participates in the protective effects from low-dose LPS in an in-vitro PC12 cell model of SCI." @default.
• W3195280212 created "2021-08-30" @default.
• W3195280212 creator A5001594032 @default.
• W3195280212 creator A5017178573 @default.
• W3195280212 creator A5018631856 @default.
• W3195280212 creator A5045288792 @default.
• W3195280212 creator A5064354572 @default.
• W3195280212 creator A5071672663 @default.
• W3195280212 date "2021-10-01" @default.
• W3195280212 modified "2023-10-18" @default.
• W3195280212 title "Low-dose lipopolysaccharide protects nerve cells against spinal cord injury via regulating the PI3K–AKT–Nrf2 signaling pathway" @default.
• W3195280212 cites W1485529498 @default.
• W3195280212 cites W1997007516 @default.
• W3195280212 cites W2040642611 @default.
• W3195280212 cites W2057062377 @default.
• W3195280212 cites W2064452102 @default.
• W3195280212 cites W2083173658 @default.
• W3195280212 cites W2084472730 @default.
• W3195280212 cites W2090051984 @default.
• W3195280212 cites W2107055340 @default.
• W3195280212 cites W2110086939 @default.
• W3195280212 cites W2113870527 @default.
• W3195280212 cites W2119991580 @default.
• W3195280212 cites W2124848084 @default.
• W3195280212 cites W2156563278 @default.
• W3195280212 cites W2188740809 @default.
• W3195280212 cites W2291354622 @default.
• W3195280212 cites W2292730121 @default.
• W3195280212 cites W2319804978 @default.
• W3195280212 cites W2337694833 @default.
• W3195280212 cites W2340076295 @default.
• W3195280212 cites W2473453460 @default.
• W3195280212 cites W2476183786 @default.
• W3195280212 cites W2726818203 @default.
• W3195280212 cites W2733014393 @default.
• W3195280212 cites W2739292292 @default.
• W3195280212 cites W2756226496 @default.
• W3195280212 cites W2761586844 @default.
• W3195280212 cites W2769198083 @default.
• W3195280212 cites W2773799482 @default.
• W3195280212 cites W2782414823 @default.
• W3195280212 cites W2789240582 @default.
• W3195280212 cites W2789843263 @default.
• W3195280212 cites W2794837739 @default.
• W3195280212 cites W2795236838 @default.
• W3195280212 cites W2943823496 @default.
• W3195280212 cites W2969040823 @default.
• W3195280212 cites W2972233352 @default.
• W3195280212 cites W2993746097 @default.
• W3195280212 cites W2999281426 @default.
• W3195280212 cites W4234276020 @default.
• W3195280212 doi "https://doi.org/10.1139/bcb-2020-0641" @default.
• W3195280212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34424795" @default.
• W3195280212 hasPublicationYear "2021" @default.
• W3195280212 type Work @default.
• W3195280212 sameAs 3195280212 @default.
• W3195280212 citedByCount "7" @default.
• W3195280212 countsByYear W31952802122022 @default.
• W3195280212 countsByYear W31952802122023 @default.
• W3195280212 crossrefType "journal-article" @default.
• W3195280212 hasAuthorship W3195280212A5001594032 @default.
• W3195280212 hasAuthorship W3195280212A5017178573 @default.
• W3195280212 hasAuthorship W3195280212A5018631856 @default.
• W3195280212 hasAuthorship W3195280212A5045288792 @default.
• W3195280212 hasAuthorship W3195280212A5064354572 @default.
• W3195280212 hasAuthorship W3195280212A5071672663 @default.
• W3195280212 hasConcept C12519072 @default.
• W3195280212 hasConcept C134018914 @default.
• W3195280212 hasConcept C185592680 @default.
• W3195280212 hasConcept C190283241 @default.
• W3195280212 hasConcept C196795494 @default.
• W3195280212 hasConcept C2776912716 @default.
• W3195280212 hasConcept C2778754761 @default.
• W3195280212 hasConcept C31573885 @default.
• W3195280212 hasConcept C55493867 @default.
• W3195280212 hasConcept C62478195 @default.
• W3195280212 hasConcept C75217442 @default.
• W3195280212 hasConcept C86554907 @default.
• W3195280212 hasConcept C86803240 @default.
• W3195280212 hasConcept C95444343 @default.
• W3195280212 hasConcept C98274493 @default.
• W3195280212 hasConceptScore W3195280212C12519072 @default.
• W3195280212 hasConceptScore W3195280212C134018914 @default.
• W3195280212 hasConceptScore W3195280212C185592680 @default.
• W3195280212 hasConceptScore W3195280212C190283241 @default.
• W3195280212 hasConceptScore W3195280212C196795494 @default.
• W3195280212 hasConceptScore W3195280212C2776912716 @default.
• W3195280212 hasConceptScore W3195280212C2778754761 @default.
• W3195280212 hasConceptScore W3195280212C31573885 @default.
• W3195280212 hasConceptScore W3195280212C55493867 @default.
• W3195280212 hasConceptScore W3195280212C62478195 @default.
• W3195280212 hasConceptScore W3195280212C75217442 @default.
• W3195280212 hasConceptScore W3195280212C86554907 @default.
• W3195280212 hasConceptScore W3195280212C86803240 @default.
• W3195280212 hasConceptScore W3195280212C95444343 @default.
• W3195280212 hasConceptScore W3195280212C98274493 @default.
• W3195280212 hasIssue "5" @default.
• W3195280212 hasLocation W31952802121 @default.

• next