FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3195306241> ?p ?o ?g. }

• W3195306241 endingPage "843" @default.
• W3195306241 startingPage "843" @default.
• W3195306241 abstract "PURPOSE Temozolomide is used in first-line treatment for glioblastoma. However, chemoresistance to temozolomide is common in glioma patients. In addition, mechanisms for the anti-tumor effects of temozolomide are largely unknown. Ferroptosis is a form of programmed cell death triggered by disturbed redox homeostasis, overloaded iron, and increased lipid peroxidation. The present study was performed to elucidate the involvement of ferroptosis in the anti-tumor mechanisms of temozolomide. MATERIALS AND METHODS We utilized the CCK8 assay to evaluate cytotoxicity. Levels of lactate dehydrogenase (LDH), malondialdehyde (MDA), iron, and glutathione (GSH) were measured. Flow cytometry and fluorescence microscope were used to detect the production of reactive oxygen species (ROS). Western blotting, RT-PCR and siRNA transfection were used to investigate molecular mechanisms. RESULTS Temozolomide increased the levels of LDH, MDA, and iron and reduced GSH levels in TG905 cells. Furthermore, we found that ROS levels and DMT1 expression were elevated in TG905 cells treated with temozolomide and were accompanied by a decrease in the expression of glutathione peroxidase 4, indicating an iron-dependent cell death, ferroptosis. Our results also showed that temozolomide-induced ferroptosis is associated with regulation of the Nrf2/HO-1 pathway. Conversely, DMT1 knockdown by siRNA evidently blocked temozolomide-induced ferroptosis in TG905 cells. CONCLUSION Taken together, our findings indicate that temozolomide may suppress cell growth partly by inducing ferroptosis by targeting DMT1 expression in glioblastoma cells." @default.
• W3195306241 created "2021-08-30" @default.
• W3195306241 creator A5011949040 @default.
• W3195306241 creator A5016365997 @default.
• W3195306241 creator A5019687039 @default.
• W3195306241 creator A5055347230 @default.
• W3195306241 creator A5075311667 @default.
• W3195306241 date "2021-01-01" @default.
• W3195306241 modified "2023-10-17" @default.
• W3195306241 title "Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells" @default.
• W3195306241 cites W1989685653 @default.
• W3195306241 cites W1997183854 @default.
• W3195306241 cites W2002490399 @default.
• W3195306241 cites W2083190417 @default.
• W3195306241 cites W2083962064 @default.
• W3195306241 cites W2096287682 @default.
• W3195306241 cites W2189205651 @default.
• W3195306241 cites W2205491921 @default.
• W3195306241 cites W2327686392 @default.
• W3195306241 cites W2508132062 @default.
• W3195306241 cites W2569483068 @default.
• W3195306241 cites W2762087180 @default.
• W3195306241 cites W2802521371 @default.
• W3195306241 cites W2886062107 @default.
• W3195306241 cites W2909817598 @default.
• W3195306241 cites W2913046536 @default.
• W3195306241 cites W2916144846 @default.
• W3195306241 cites W2917273531 @default.
• W3195306241 cites W2939322913 @default.
• W3195306241 cites W2971991049 @default.
• W3195306241 cites W2986535915 @default.
• W3195306241 cites W3020593143 @default.
• W3195306241 cites W3044608231 @default.
• W3195306241 cites W4234865248 @default.
• W3195306241 doi "https://doi.org/10.3349/ymj.2021.62.9.843" @default.
• W3195306241 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8382730" @default.
• W3195306241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34427071" @default.
• W3195306241 hasPublicationYear "2021" @default.
• W3195306241 type Work @default.
• W3195306241 sameAs 3195306241 @default.
• W3195306241 citedByCount "35" @default.
• W3195306241 countsByYear W31953062412022 @default.
• W3195306241 countsByYear W31953062412023 @default.
• W3195306241 crossrefType "journal-article" @default.
• W3195306241 hasAuthorship W3195306241A5011949040 @default.
• W3195306241 hasAuthorship W3195306241A5016365997 @default.
• W3195306241 hasAuthorship W3195306241A5019687039 @default.
• W3195306241 hasAuthorship W3195306241A5055347230 @default.
• W3195306241 hasAuthorship W3195306241A5075311667 @default.
• W3195306241 hasBestOaLocation W31953062411 @default.
• W3195306241 hasConcept C173396325 @default.
• W3195306241 hasConcept C181199279 @default.
• W3195306241 hasConcept C185592680 @default.
• W3195306241 hasConcept C190283241 @default.
• W3195306241 hasConcept C2776151105 @default.
• W3195306241 hasConcept C2777389519 @default.
• W3195306241 hasConcept C2778227246 @default.
• W3195306241 hasConcept C2778401633 @default.
• W3195306241 hasConcept C31573885 @default.
• W3195306241 hasConcept C48349386 @default.
• W3195306241 hasConcept C502942594 @default.
• W3195306241 hasConcept C538909803 @default.
• W3195306241 hasConcept C55493867 @default.
• W3195306241 hasConcept C86803240 @default.
• W3195306241 hasConcept C98274493 @default.
• W3195306241 hasConceptScore W3195306241C173396325 @default.
• W3195306241 hasConceptScore W3195306241C181199279 @default.
• W3195306241 hasConceptScore W3195306241C185592680 @default.
• W3195306241 hasConceptScore W3195306241C190283241 @default.
• W3195306241 hasConceptScore W3195306241C2776151105 @default.
• W3195306241 hasConceptScore W3195306241C2777389519 @default.
• W3195306241 hasConceptScore W3195306241C2778227246 @default.
• W3195306241 hasConceptScore W3195306241C2778401633 @default.
• W3195306241 hasConceptScore W3195306241C31573885 @default.
• W3195306241 hasConceptScore W3195306241C48349386 @default.
• W3195306241 hasConceptScore W3195306241C502942594 @default.
• W3195306241 hasConceptScore W3195306241C538909803 @default.
• W3195306241 hasConceptScore W3195306241C55493867 @default.
• W3195306241 hasConceptScore W3195306241C86803240 @default.
• W3195306241 hasConceptScore W3195306241C98274493 @default.
• W3195306241 hasFunder F4320321001 @default.
• W3195306241 hasFunder F4320324174 @default.
• W3195306241 hasIssue "9" @default.
• W3195306241 hasLocation W31953062411 @default.
• W3195306241 hasLocation W31953062412 @default.
• W3195306241 hasOpenAccess W3195306241 @default.
• W3195306241 hasPrimaryLocation W31953062411 @default.
• W3195306241 hasRelatedWork W2019660019 @default.
• W3195306241 hasRelatedWork W2041270844 @default.
• W3195306241 hasRelatedWork W2084605009 @default.
• W3195306241 hasRelatedWork W2332433189 @default.
• W3195306241 hasRelatedWork W2567075592 @default.
• W3195306241 hasRelatedWork W2590702614 @default.
• W3195306241 hasRelatedWork W2593895879 @default.
• W3195306241 hasRelatedWork W3013584387 @default.
• W3195306241 hasRelatedWork W3019450950 @default.
• W3195306241 hasRelatedWork W3185385391 @default.
• W3195306241 hasVolume "62" @default.

• next