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- W3195314894 abstract "BACKGROUND AND AIM: Previous cross-sectional research has shown metals are associated with decreases in lung function in children. The influence of prenatal metals exposure on childhood lung function remains understudied. This study aimed to determine if prenatal metals exposure predicts childhood lung function, and assess effect modification by child sex. METHODS: We assessed 217 mother-child dyads enrolled in the Programming Research in Obesity, Growth, Environment, and Social Stressors birth cohort in Mexico City. Maternal blood samples were measured for lead, arsenic, and manganese in pregnant women during their 2nd trimester using plasma-mass spectrometry. Between 8-11 years of age, lung function was tested by pre- and post- bronchodilator spirometry. Outcomes included z-scores for forced expiratory volume in one second (FEV1), forced vital capacity (FVC), FEV1/FVC and forced expiratory flow at 25-75% of the pulmonary volume (FEF25-75) in separate models. We conducted multiple linear regression to evaluate the association between prenatal metals and post-bronchodilator childhood lung function adjusting for maternal age, education, and environmental tobacco smoke exposure and mutually adjusting for other metals. Models were then stratified by child sex to assess effect modification. RESULTS:Prenatal blood lead (1.13+0.60) was marginally associated with lower FEV1 (β -0.20, 95% CI: -0.43, -0.03), and lower FVC (β: -0.20, 95% CI: -0.42, 0.03). We did not find significant main effects of arsenic or manganese on lung function outcomes. When stratified by sex, lead was associated with lower FEF25-75% (β: -0.27, 95% CI: -0.53, -0.02) among boys but not in girls (β: 0.07, 95% CI: -0.32, 0.46). CONCLUSIONS:Prenatal lead was marginally associated with decreased lung function in childhood and appeared to be modified by child sex. These findings underscore the need to consider prenatal metal effects on childhood lung function. KEYWORDS: children's environmental health, heavy metals, pediatric lung function" @default.
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- W3195314894 date "2021-08-23" @default.
- W3195314894 modified "2023-09-23" @default.
- W3195314894 title "Association between prenatal metals exposure and childhood lung function" @default.
- W3195314894 doi "https://doi.org/10.1289/isee.2021.o-to-170" @default.
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