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- W3195374522 abstract "Abstract Magnetic nanoparticles (MNPs) are widely known as valuable agents for biomedical applications. Yet, for their successful application within cells they need to fulfill a variety of demands such as monodispersity, biocompatibility or sufficient magnetic response. Given these prerequisites, MNPs may be used for remote, non-invasive manipulation, where their spatial redistribution or force response in a magnetic field provides a fine-tunable stimulus to a cell. Here, we investigate the properties of two different MNPs and their suitability for spatio-mechanical manipulations: semisynthetic magnetoferritin nanoparticles and fully synthetic ‘nanoflower’-shaped iron-oxide nanoparticles. Next to characterizing their structure, surface potential and magnetic response, we monitor the MNP performance in a living cell environment using fluorescence microscopy and confirm their biocompatibility. We then demonstrate their capability to spatially redistribute and to respond to magnetic force gradients inside a cell. Our remote manipulation assays present these tailored magnetic materials as suitable agents for applications in magnetogenetics, biomedicine or nanomaterial research." @default.
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- W3195374522 date "2021-08-16" @default.
- W3195374522 modified "2023-10-15" @default.
- W3195374522 title "Magnetic Nanoprobes for Spatio-Mechanical Manipulation in Single Cells" @default.
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- W3195374522 doi "https://doi.org/10.1101/2021.08.16.455233" @default.
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