Matches in SemOpenAlex for { <https://semopenalex.org/work/W3195422208> ?p ?o ?g. }
- W3195422208 abstract "Abstract Homologous recombination (HR) is a complex DNA damage repair pathway and an attractive target of inhibition in anti-cancer therapy. To help guide the development of efficient HR inhibitors, it is critical to identify compensatory sub-pathways. In this study, we describe a novel synthetic interaction between RAD51AP1 and RAD54, two structurally unrelated proteins that function downstream of the RAD51 recombinase in HR. We show that deletion of both RAD51AP1 and RAD54 synergistically sensitizes human cancer cell lines to treatment with a Poly(adenosine 5’ s-diphosphate-ribose) polymerase inhibitor, to the DNA inter-strand crosslinking agent mitomycin C, and to hydroxyurea, which stalls the progression of DNA replication forks. We infer that HR-directed anti-cancer treatment modalities shall consider this intra-pathway functional overlap, and we hypothesize that in cancerous cells the simultaneous inactivation of both RAD54 and RAD51AP1 will accentuate tumor kill." @default.
- W3195422208 created "2021-08-30" @default.
- W3195422208 creator A5005189404 @default.
- W3195422208 creator A5048574811 @default.
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- W3195422208 creator A5081233004 @default.
- W3195422208 creator A5088902115 @default.
- W3195422208 creator A5090899284 @default.
- W3195422208 date "2021-07-15" @default.
- W3195422208 modified "2023-09-24" @default.
- W3195422208 title "RAD51AP1 and RAD54 underpin two distinct RAD51-dependent routes of DNA damage repair via homologous recombination" @default.
- W3195422208 cites W1521943738 @default.
- W3195422208 cites W1537804570 @default.
- W3195422208 cites W1676891985 @default.
- W3195422208 cites W1896395394 @default.
- W3195422208 cites W1966320645 @default.
- W3195422208 cites W1969896771 @default.
- W3195422208 cites W1970578083 @default.
- W3195422208 cites W1973268287 @default.
- W3195422208 cites W1981258136 @default.
- W3195422208 cites W1983310944 @default.
- W3195422208 cites W1989388273 @default.
- W3195422208 cites W1991427783 @default.
- W3195422208 cites W1995437551 @default.
- W3195422208 cites W1997863177 @default.
- W3195422208 cites W2003438913 @default.
- W3195422208 cites W2004337269 @default.
- W3195422208 cites W2004867792 @default.
- W3195422208 cites W2006895915 @default.
- W3195422208 cites W2009007206 @default.
- W3195422208 cites W2022100127 @default.
- W3195422208 cites W2023257987 @default.
- W3195422208 cites W2029164849 @default.
- W3195422208 cites W2029533968 @default.
- W3195422208 cites W2034409892 @default.
- W3195422208 cites W2034702779 @default.
- W3195422208 cites W2036905821 @default.
- W3195422208 cites W2039057244 @default.
- W3195422208 cites W2047504175 @default.
- W3195422208 cites W2048728990 @default.
- W3195422208 cites W2057132693 @default.
- W3195422208 cites W2057347731 @default.
- W3195422208 cites W2060993163 @default.
- W3195422208 cites W2062739292 @default.
- W3195422208 cites W2066883074 @default.
- W3195422208 cites W2089804282 @default.
- W3195422208 cites W2090160970 @default.
- W3195422208 cites W2090263062 @default.
- W3195422208 cites W2091715532 @default.
- W3195422208 cites W2098126099 @default.
- W3195422208 cites W2100122430 @default.
- W3195422208 cites W2104584181 @default.
- W3195422208 cites W2108630902 @default.
- W3195422208 cites W2109038089 @default.
- W3195422208 cites W2111490168 @default.
- W3195422208 cites W2113125265 @default.
- W3195422208 cites W2114436777 @default.
- W3195422208 cites W2118342658 @default.
- W3195422208 cites W2122816558 @default.
- W3195422208 cites W2137347518 @default.
- W3195422208 cites W2145537290 @default.
- W3195422208 cites W2146533600 @default.
- W3195422208 cites W2150453102 @default.
- W3195422208 cites W2150676054 @default.
- W3195422208 cites W2151318295 @default.
- W3195422208 cites W2154317163 @default.
- W3195422208 cites W2158526159 @default.
- W3195422208 cites W2166510365 @default.
- W3195422208 cites W2168799519 @default.
- W3195422208 cites W2170509903 @default.
- W3195422208 cites W2170725518 @default.
- W3195422208 cites W2320271732 @default.
- W3195422208 cites W2334990949 @default.
- W3195422208 cites W2409391306 @default.
- W3195422208 cites W2513670757 @default.
- W3195422208 cites W2762278714 @default.
- W3195422208 cites W2763077107 @default.
- W3195422208 cites W2763248055 @default.
- W3195422208 cites W2765875601 @default.
- W3195422208 cites W2767368861 @default.
- W3195422208 cites W2785672263 @default.
- W3195422208 cites W2810748925 @default.
- W3195422208 cites W2891478738 @default.
- W3195422208 cites W2955745836 @default.
- W3195422208 cites W2991449575 @default.
- W3195422208 cites W3015980070 @default.
- W3195422208 cites W3033655624 @default.
- W3195422208 cites W3042118153 @default.
- W3195422208 cites W3082542703 @default.
- W3195422208 cites W3082767637 @default.
- W3195422208 cites W3099646310 @default.
- W3195422208 cites W3099886820 @default.
- W3195422208 cites W3102726164 @default.
- W3195422208 cites W3108403304 @default.
- W3195422208 cites W3113118871 @default.
- W3195422208 cites W3118998329 @default.
- W3195422208 cites W3120569436 @default.
- W3195422208 cites W3125948939 @default.
- W3195422208 cites W3160242511 @default.
- W3195422208 cites W3161529933 @default.