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- W3195431345 abstract "Interneurons are critical for information processing in the cortex. In vitro optogenetic studies in mouse primary visual cortex (V1) have sketched the connectivity of a local neural circuit comprising excitatory pyramidal neurons and distinct interneuron subtypes that express parvalbumin (Pvalb+), somatostatin (SOM+), or vasoactive intestinal peptide (VIP+). However, in vivo studies focusing on V1 orientation tuning have ascribed discrepant computational roles to specific interneuron subtypes. Here, we sought to clarify the differences between interneuron subtypes by examining the effects of optogenetic activation of Pvalb+, SOM+, or VIP+ interneurons on contrast tuning of V1 neurons while also accounting for cortical depth and photostimulation intensity. We found that illumination of the cortical surface produced a similar spectrum of saturating additive photostimulation effects in all 3 interneuron subtypes, which varied with cortical depth rather than light intensity in Pvalb+ and SOM+ cells. Pyramidal cell modulation was well explained by a conductance-based model that incorporated these interneuron photostimulation effects." @default.
- W3195431345 created "2021-08-30" @default.
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- W3195431345 creator A5030977049 @default.
- W3195431345 date "2021-08-18" @default.
- W3195431345 modified "2023-10-01" @default.
- W3195431345 title "Optogenetic Activation of Interneuron Subtypes Modulates Visual Contrast Responses of Mouse V1 Neurons" @default.
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- W3195431345 doi "https://doi.org/10.1093/cercor/bhab269" @default.
- W3195431345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34411240" @default.
- W3195431345 hasPublicationYear "2021" @default.
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