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- W3195432836 endingPage "8941" @default.
- W3195432836 startingPage "8941" @default.
- W3195432836 abstract "Endogenous DNA derived from the nuclei or mitochondria is released into the bloodstream following cell damage or death. Extracellular DNA, called cell-free DNA (cfDNA), is associated with various pathological conditions. Recently, multiple aspects of cfDNA have been assessed, including cfDNA levels, integrity, methylation, and mutations. Rheumatoid arthritis (RA) is the most common form of autoimmune arthritis, and treatment of RA has highly varied outcomes. cfDNA in patients with RA is elevated in peripheral blood and synovial fluid and is associated with disease activity. Profiling of cfDNA in patients with RA may then be utilized in various aspects of clinical practice, such as the prediction of prognosis and treatment responses; monitoring disease state; and as a diagnostic marker. In this review, we discuss cfDNA in patients with RA, particularly the sources of cfDNA and the correlation of cfDNA with RA pathogenesis. We also highlight the potential of analyzing cfDNA profiles to guide individualized treatment approaches for RA." @default.
- W3195432836 created "2021-08-30" @default.
- W3195432836 creator A5013999373 @default.
- W3195432836 creator A5050749299 @default.
- W3195432836 creator A5054553529 @default.
- W3195432836 creator A5072169429 @default.
- W3195432836 date "2021-08-19" @default.
- W3195432836 modified "2023-10-12" @default.
- W3195432836 title "Cell-Free DNA in Rheumatoid Arthritis" @default.
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