FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3195442203> ?p ?o ?g. }

• W3195442203 endingPage "8988" @default.
• W3195442203 startingPage "8988" @default.
• W3195442203 abstract "Sciatic nerve injury (SNI) leads to sensory and motor dysfunctions. Nobiletin is a major component of polymethoxylated flavonoid extracted from citrus fruits. The role of nobiletin on sciatic nerve regeneration is still unclear. Thus, the purpose of this study was to investigate whether nobiletin increases DRG neurite elongation and regeneration-related protein expression after SNI. Cytotoxicity of nobiletin was measured in a concentration-dependent manner using the MTT assay. For an in vitro primary cell culture, the sciatic nerve on the middle thigh was crushed by holding twice with forceps. Dorsal root ganglion (DRG) and Schwann cells were cultured 3 days after SNI and harvested 36 h later and 3 days later, respectively. In order to evaluate specific regeneration-related markers and axon growth in the injured sciatic nerve, we applied immunofluorescence staining and Western blot techniques. Nobiletin increased cell viability in human neuroblastoma cells and inhibited cytotoxicity induced by exposure to H2O2. Mean neurite length of DRG neurons was significantly increased in the nobiletin group at a dose of 50 and 100 μM compared to those at other concentrations. GAP-43, a specific marker for axonal regeneration, was enhanced in injury preconditioned Schwann cells with nobiletin treatment and nobiletin significantly upregulated it in injured sciatic nerve at only 3 days post crush (dpc). In addition, nobiletin dramatically facilitated axonal regrowth via activation of the BDNF-ERK1/2 and AKT pathways. These results should provide evidence to distinguish more accurately the biochemical mechanisms regarding nobiletin-activated sciatic nerve regeneration." @default.
• W3195442203 created "2021-08-30" @default.
• W3195442203 creator A5021656946 @default.
• W3195442203 creator A5045203074 @default.
• W3195442203 creator A5072589128 @default.
• W3195442203 creator A5087410320 @default.
• W3195442203 date "2021-08-26" @default.
• W3195442203 modified "2023-10-14" @default.
• W3195442203 title "In Vitro and In Vivo Effects of Nobiletin on DRG Neurite Elongation and Axon Growth after Sciatic Nerve Injury" @default.
• W3195442203 cites W1921573595 @default.
• W3195442203 cites W1934034828 @default.
• W3195442203 cites W1976441097 @default.
• W3195442203 cites W1976601848 @default.
• W3195442203 cites W1977228353 @default.
• W3195442203 cites W1982621565 @default.
• W3195442203 cites W1986243691 @default.
• W3195442203 cites W2034695607 @default.
• W3195442203 cites W2035164721 @default.
• W3195442203 cites W2042198607 @default.
• W3195442203 cites W2056522555 @default.
• W3195442203 cites W2066719352 @default.
• W3195442203 cites W2076517679 @default.
• W3195442203 cites W2077556631 @default.
• W3195442203 cites W2077984299 @default.
• W3195442203 cites W2079387502 @default.
• W3195442203 cites W2086724431 @default.
• W3195442203 cites W2119122217 @default.
• W3195442203 cites W2120234533 @default.
• W3195442203 cites W2238078545 @default.
• W3195442203 cites W2294946878 @default.
• W3195442203 cites W2524248777 @default.
• W3195442203 cites W2807036634 @default.
• W3195442203 cites W2838427490 @default.
• W3195442203 cites W2899962737 @default.
• W3195442203 cites W2937159597 @default.
• W3195442203 cites W2959612888 @default.
• W3195442203 cites W2961915187 @default.
• W3195442203 cites W2969552620 @default.
• W3195442203 cites W2971079539 @default.
• W3195442203 cites W2988979774 @default.
• W3195442203 cites W2989772410 @default.
• W3195442203 cites W3006046471 @default.
• W3195442203 cites W3015088345 @default.
• W3195442203 doi "https://doi.org/10.3390/ijerph18178988" @default.
• W3195442203 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8431276" @default.
• W3195442203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34501579" @default.
• W3195442203 hasPublicationYear "2021" @default.
• W3195442203 type Work @default.
• W3195442203 sameAs 3195442203 @default.
• W3195442203 citedByCount "1" @default.
• W3195442203 crossrefType "journal-article" @default.
• W3195442203 hasAuthorship W3195442203A5021656946 @default.
• W3195442203 hasAuthorship W3195442203A5045203074 @default.
• W3195442203 hasAuthorship W3195442203A5072589128 @default.
• W3195442203 hasAuthorship W3195442203A5087410320 @default.
• W3195442203 hasBestOaLocation W31954422031 @default.
• W3195442203 hasConcept C105702510 @default.
• W3195442203 hasConcept C113246987 @default.
• W3195442203 hasConcept C140530291 @default.
• W3195442203 hasConcept C16993767 @default.
• W3195442203 hasConcept C171056886 @default.
• W3195442203 hasConcept C185592680 @default.
• W3195442203 hasConcept C202751555 @default.
• W3195442203 hasConcept C2775991916 @default.
• W3195442203 hasConcept C2776281502 @default.
• W3195442203 hasConcept C2776588550 @default.
• W3195442203 hasConcept C2776880756 @default.
• W3195442203 hasConcept C2778004101 @default.
• W3195442203 hasConcept C2778401301 @default.
• W3195442203 hasConcept C2779054382 @default.
• W3195442203 hasConcept C2779530196 @default.
• W3195442203 hasConcept C2781149210 @default.
• W3195442203 hasConcept C42219234 @default.
• W3195442203 hasConcept C55493867 @default.
• W3195442203 hasConcept C71924100 @default.
• W3195442203 hasConcept C86803240 @default.
• W3195442203 hasConcept C90149880 @default.
• W3195442203 hasConcept C94412978 @default.
• W3195442203 hasConcept C95444343 @default.
• W3195442203 hasConcept C98274493 @default.
• W3195442203 hasConceptScore W3195442203C105702510 @default.
• W3195442203 hasConceptScore W3195442203C113246987 @default.
• W3195442203 hasConceptScore W3195442203C140530291 @default.
• W3195442203 hasConceptScore W3195442203C16993767 @default.
• W3195442203 hasConceptScore W3195442203C171056886 @default.
• W3195442203 hasConceptScore W3195442203C185592680 @default.
• W3195442203 hasConceptScore W3195442203C202751555 @default.
• W3195442203 hasConceptScore W3195442203C2775991916 @default.
• W3195442203 hasConceptScore W3195442203C2776281502 @default.
• W3195442203 hasConceptScore W3195442203C2776588550 @default.
• W3195442203 hasConceptScore W3195442203C2776880756 @default.
• W3195442203 hasConceptScore W3195442203C2778004101 @default.
• W3195442203 hasConceptScore W3195442203C2778401301 @default.
• W3195442203 hasConceptScore W3195442203C2779054382 @default.
• W3195442203 hasConceptScore W3195442203C2779530196 @default.
• W3195442203 hasConceptScore W3195442203C2781149210 @default.
• W3195442203 hasConceptScore W3195442203C42219234 @default.
• W3195442203 hasConceptScore W3195442203C55493867 @default.

• next