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- W3195461164 abstract "Several FGF5 mutations are associated with hair length variation in many domestic animals, including New World camelids. The dromedary was investigated in the present study with breeds exhibiting marked variations in hair length. This study aimed to: (1) identify the molecular variation(s) in the three exons of FGF5 of a diverse group of breeds (Mejaheem, Shaele, Sofor, Waddah and Omani; n = 28); (2) examine the association of the identified variants with hair length; (3) validate the association via genotyping the polymorphism in a large population of diverse camels (n = 113); and (4) test the segregation of the identified variant with hair length in a pedigree. A non-synonymous mutation (c.779 C > T) was identified that changes the amino acid from proline to leucine and was found to be associated with different hair length in dromedaries. The variants at c.779 displayed a co-dominance mode of inheritance and three hair length phenotypes: short (C/C), intermediate (C/T) and long (T/T). Across the examined dromedary breeds, both alleles were present, which is probably due to the breeders' preference for an intermediate hair length. When compared with other camelids, the identified variant was found exclusively in dromedaries with the ancestral allele at c.779 being 'C'. This study constitutes the first thorough exploration of the FGF5 gene in dromedaries." @default.
- W3195461164 created "2021-08-30" @default.
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- W3195461164 date "2021-08-25" @default.
- W3195461164 modified "2023-09-27" @default.
- W3195461164 title "<i>FGF5</i> missense mutation is associated with dromedary hair length variation" @default.
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- W3195461164 doi "https://doi.org/10.1111/age.13132" @default.
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