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- W3195524856 abstract "Summary How environmental cues influence peroxisome proliferation, particularly through other organelles, remains largely unknown. Yeast peroxisomes metabolize all fatty acids (FA), and methylotrophic yeasts also metabolize methanol. NADH and acetyl-CoA, the products of these pathways enter mitochondria for ATP production, and for anabolic reactions. During the metabolism of FA and/or methanol, the mitochondrial oxidative phosphorylation (OXPHOS) pathway accepts NADH for ATP production and maintains cellular redox balance. Remarkably, peroxisome proliferation in Pichia pastoris was abolished in NADH shuttling and OXPHOS mutants affecting complex I or III, or by the mitochondrial uncoupler, 2,4-dinitrophenol (DNP), indicating ATP depletion causes the phenotype. We show that mitochondrial OXPHOS deficiency inhibits the expression of several peroxisomal proteins implicated in FA and methanol metabolism, as well as in peroxisome division and proliferation. These genes are regulated by the Snf1 complex (SNF1), a pathway generally activated by high AMP and low ATP. Consistent with this mechanism, in OXPHOS mutants, Snf1 is activated by phosphorylation, but Gal83, its interacting subunit, fails to translocate to the nucleus. Phenotypic defects in peroxisome proliferation observed in the OXPHOS mutants, and phenocopied by the Δgal83 mutant, were rescued by deletion of three transcriptional repressor genes ( MIG1 , MIG2 and NRG1 ) controlled by SNF1 signaling. We uncovered here the mechanism by which peroxisomal and mitochondrial metabolites influence redox and energy metabolism, while also influencing peroxisome biogenesis and proliferation, thereby exemplifying interorganellar communication and interplay involving peroxisomes, mitochondria, cytosol and the nucleus. We discuss the physiological relevance of this work in view of human OXPHOS deficiencies." @default.
- W3195524856 created "2021-08-30" @default.
- W3195524856 creator A5053080222 @default.
- W3195524856 creator A5056990606 @default.
- W3195524856 creator A5057399616 @default.
- W3195524856 creator A5065329251 @default.
- W3195524856 date "2021-08-23" @default.
- W3195524856 modified "2023-10-16" @default.
- W3195524856 title "OXPHOS deficiencies affect peroxisome proliferation by downregulating genes controlled by the SNF1 signaling pathway" @default.
- W3195524856 cites W115314615 @default.
- W3195524856 cites W1518753085 @default.
- W3195524856 cites W1550242218 @default.
- W3195524856 cites W1743227192 @default.
- W3195524856 cites W1816026494 @default.
- W3195524856 cites W1819996027 @default.
- W3195524856 cites W1825061872 @default.
- W3195524856 cites W1873692790 @default.
- W3195524856 cites W1899241056 @default.
- W3195524856 cites W1955808217 @default.
- W3195524856 cites W1965448184 @default.
- W3195524856 cites W1966878870 @default.
- W3195524856 cites W1972926511 @default.
- W3195524856 cites W1976613901 @default.
- W3195524856 cites W1979961115 @default.
- W3195524856 cites W1986426537 @default.
- W3195524856 cites W1991020543 @default.
- W3195524856 cites W1991890196 @default.
- W3195524856 cites W1993765043 @default.
- W3195524856 cites W2001847464 @default.
- W3195524856 cites W2001882267 @default.
- W3195524856 cites W2002118920 @default.
- W3195524856 cites W2006404990 @default.
- W3195524856 cites W2015905425 @default.
- W3195524856 cites W2016136365 @default.
- W3195524856 cites W2019148902 @default.
- W3195524856 cites W2024405457 @default.
- W3195524856 cites W2027662514 @default.
- W3195524856 cites W2031270050 @default.
- W3195524856 cites W2035686263 @default.
- W3195524856 cites W2037024540 @default.
- W3195524856 cites W2038572774 @default.
- W3195524856 cites W2041343852 @default.
- W3195524856 cites W2042271239 @default.
- W3195524856 cites W2047373064 @default.
- W3195524856 cites W2050613337 @default.
- W3195524856 cites W2054852006 @default.
- W3195524856 cites W2058929656 @default.
- W3195524856 cites W2059825898 @default.
- W3195524856 cites W2060909570 @default.
- W3195524856 cites W2062341760 @default.
- W3195524856 cites W2062401556 @default.
- W3195524856 cites W2064649360 @default.
- W3195524856 cites W2073697032 @default.
- W3195524856 cites W2075946124 @default.
- W3195524856 cites W2080174082 @default.
- W3195524856 cites W2083018502 @default.
- W3195524856 cites W2089714024 @default.
- W3195524856 cites W2096470134 @default.
- W3195524856 cites W2099389787 @default.
- W3195524856 cites W2099508466 @default.
- W3195524856 cites W2099685366 @default.
- W3195524856 cites W2099788003 @default.
- W3195524856 cites W2101678382 @default.
- W3195524856 cites W2102303401 @default.
- W3195524856 cites W2105165430 @default.
- W3195524856 cites W2105740329 @default.
- W3195524856 cites W2107277218 @default.
- W3195524856 cites W2110072051 @default.
- W3195524856 cites W2117963696 @default.
- W3195524856 cites W2120666943 @default.
- W3195524856 cites W2122034403 @default.
- W3195524856 cites W2131509316 @default.
- W3195524856 cites W2134314989 @default.
- W3195524856 cites W2139443530 @default.
- W3195524856 cites W2139834134 @default.
- W3195524856 cites W2143907477 @default.
- W3195524856 cites W2147635825 @default.
- W3195524856 cites W2148766990 @default.
- W3195524856 cites W2151833520 @default.
- W3195524856 cites W2154954842 @default.
- W3195524856 cites W2159803276 @default.
- W3195524856 cites W2161184130 @default.
- W3195524856 cites W2168222044 @default.
- W3195524856 cites W2170322333 @default.
- W3195524856 cites W2177691638 @default.
- W3195524856 cites W2301304613 @default.
- W3195524856 cites W2465324331 @default.
- W3195524856 cites W2466016097 @default.
- W3195524856 cites W2511848899 @default.
- W3195524856 cites W25209553 @default.
- W3195524856 cites W2526145362 @default.
- W3195524856 cites W2560721383 @default.
- W3195524856 cites W2577514807 @default.
- W3195524856 cites W2585385849 @default.
- W3195524856 cites W2602059628 @default.
- W3195524856 cites W2609632857 @default.
- W3195524856 cites W2617326069 @default.
- W3195524856 cites W2755926712 @default.
- W3195524856 cites W2763871199 @default.
- W3195524856 cites W2770117242 @default.