Matches in SemOpenAlex for { <https://semopenalex.org/work/W3195607238> ?p ?o ?g. }
- W3195607238 endingPage "1353" @default.
- W3195607238 startingPage "1342" @default.
- W3195607238 abstract "Abstract CD8+ T cells recognize peptides displayed by HLA class I molecules on cell surfaces, monitoring pathologic conditions such as cancer. Advances in proteogenomic analysis of HLA ligandomes have demonstrated that cells present a subset of cryptic peptides derived from noncoding regions of the genome; however, the roles of cryptic HLA ligands in tumor immunity remain unknown. In the current study, we comprehensively and quantitatively investigated the HLA class I ligandome of a set of human colorectal cancer and matched normal tissues, showing that cryptic translation products accounted for approximately 5% of the HLA class I ligandome. We also found that a peptide encoded by the long noncoding RNA (lncRNA) PVT1 was predominantly enriched in multiple colorectal cancer tissues. The PVT1 gene is located downstream of the MYC gene in the genome and is aberrantly overexpressed across a variety of cancers, reflecting its oncogenic property. The PVT1 peptide was recognized by patient CD8+ tumor-infiltrating lymphocytes, as well as peripheral blood mononuclear cells, suggesting the presence of patient immune surveillance. Our findings show that peptides can be translated from lncRNAs and presented by HLA class I and that cancer patient T cells are capable of sensing aberrations in noncoding regions of the genome." @default.
- W3195607238 created "2021-08-30" @default.
- W3195607238 creator A5000123851 @default.
- W3195607238 creator A5001863693 @default.
- W3195607238 creator A5004878380 @default.
- W3195607238 creator A5023078180 @default.
- W3195607238 creator A5027125823 @default.
- W3195607238 creator A5031999236 @default.
- W3195607238 creator A5037167618 @default.
- W3195607238 creator A5053163842 @default.
- W3195607238 creator A5058935732 @default.
- W3195607238 creator A5061939029 @default.
- W3195607238 creator A5072637751 @default.
- W3195607238 creator A5084763881 @default.
- W3195607238 creator A5086646979 @default.
- W3195607238 date "2021-08-25" @default.
- W3195607238 modified "2023-10-16" @default.
- W3195607238 title "CD8+ T–cell Immune Surveillance against a Tumor Antigen Encoded by the Oncogenic Long Noncoding RNA <i>PVT1</i>" @default.
- W3195607238 cites W1820845817 @default.
- W3195607238 cites W1965266522 @default.
- W3195607238 cites W1974894365 @default.
- W3195607238 cites W1977572305 @default.
- W3195607238 cites W1995317534 @default.
- W3195607238 cites W2029919331 @default.
- W3195607238 cites W2033308373 @default.
- W3195607238 cites W2039085967 @default.
- W3195607238 cites W2048120844 @default.
- W3195607238 cites W2049514376 @default.
- W3195607238 cites W2056499061 @default.
- W3195607238 cites W2063511434 @default.
- W3195607238 cites W2069655759 @default.
- W3195607238 cites W2069860553 @default.
- W3195607238 cites W2073621589 @default.
- W3195607238 cites W2082566384 @default.
- W3195607238 cites W2085220756 @default.
- W3195607238 cites W2089822384 @default.
- W3195607238 cites W2092467693 @default.
- W3195607238 cites W2095139077 @default.
- W3195607238 cites W2100424218 @default.
- W3195607238 cites W2102237050 @default.
- W3195607238 cites W2110957978 @default.
- W3195607238 cites W2127230663 @default.
- W3195607238 cites W2128623999 @default.
- W3195607238 cites W2142300779 @default.
- W3195607238 cites W2153056550 @default.
- W3195607238 cites W2162547088 @default.
- W3195607238 cites W2166810745 @default.
- W3195607238 cites W2205343347 @default.
- W3195607238 cites W2255242978 @default.
- W3195607238 cites W2335029242 @default.
- W3195607238 cites W2412171122 @default.
- W3195607238 cites W2469746525 @default.
- W3195607238 cites W2514929667 @default.
- W3195607238 cites W2533508881 @default.
- W3195607238 cites W2567665210 @default.
- W3195607238 cites W2588455501 @default.
- W3195607238 cites W2613292714 @default.
- W3195607238 cites W2767309126 @default.
- W3195607238 cites W2784686711 @default.
- W3195607238 cites W2804073610 @default.
- W3195607238 cites W2898598946 @default.
- W3195607238 cites W2903083041 @default.
- W3195607238 cites W2924359886 @default.
- W3195607238 cites W2927587991 @default.
- W3195607238 cites W2947880448 @default.
- W3195607238 cites W2952666313 @default.
- W3195607238 cites W3004329125 @default.
- W3195607238 cites W3010737707 @default.
- W3195607238 cites W3023418641 @default.
- W3195607238 cites W3036877448 @default.
- W3195607238 cites W798940297 @default.
- W3195607238 doi "https://doi.org/10.1158/2326-6066.cir-20-0964" @default.
- W3195607238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34433589" @default.
- W3195607238 hasPublicationYear "2021" @default.
- W3195607238 type Work @default.
- W3195607238 sameAs 3195607238 @default.
- W3195607238 citedByCount "16" @default.
- W3195607238 countsByYear W31956072382021 @default.
- W3195607238 countsByYear W31956072382022 @default.
- W3195607238 countsByYear W31956072382023 @default.
- W3195607238 crossrefType "journal-article" @default.
- W3195607238 hasAuthorship W3195607238A5000123851 @default.
- W3195607238 hasAuthorship W3195607238A5001863693 @default.
- W3195607238 hasAuthorship W3195607238A5004878380 @default.
- W3195607238 hasAuthorship W3195607238A5023078180 @default.
- W3195607238 hasAuthorship W3195607238A5027125823 @default.
- W3195607238 hasAuthorship W3195607238A5031999236 @default.
- W3195607238 hasAuthorship W3195607238A5037167618 @default.
- W3195607238 hasAuthorship W3195607238A5053163842 @default.
- W3195607238 hasAuthorship W3195607238A5058935732 @default.
- W3195607238 hasAuthorship W3195607238A5061939029 @default.
- W3195607238 hasAuthorship W3195607238A5072637751 @default.
- W3195607238 hasAuthorship W3195607238A5084763881 @default.
- W3195607238 hasAuthorship W3195607238A5086646979 @default.
- W3195607238 hasBestOaLocation W31956072381 @default.
- W3195607238 hasConcept C104317684 @default.
- W3195607238 hasConcept C121608353 @default.
- W3195607238 hasConcept C141231307 @default.