FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3195639829> ?p ?o ?g. }

• W3195639829 endingPage "126848" @default.
• W3195639829 startingPage "126848" @default.
• W3195639829 abstract "Thallium (Tl) is a toxic metalloid and an emerging pollutant due to electronic devices and dispersal nearby base-metal mining. Therefore, Tl poses a threat to human health and especially the long-term impact on younger individuals exposed is still unknown. This study aimed to evaluate the toxic effects of thallium acetate in C. elegans in early larval stages, considering physiological and behavioral endpoints, as well as the Tl absorption and bioaccumulation.Caenorhabditis elegans (C. elegans) was exposed to Thallium acetate (50, 100, 150, 200, 250, 500, and 1000 μM) in the L1 larval stage, with the purpose to observe the toxic effects invoked until adulthood. Transgenic worms strains were transported GFP, reporters to DAF-16 and were used to verify the antioxidant response. ICP-MS quantified total Tl+ concentration to evidence Tl uptake and bioaccumulation.Thallium acetate caused a significant reduction in the number of living worms (p < 0.0001 in 100-1000 μM), a delay in larval development (p < 0.01; p < 0.001 and p < 0.0001 in 100-1000 μM) through the larval stages, and egg production in the worm's uterus was reduced. Thallium acetate also induced behavioral changes. Additionally, thallium acetate activated antioxidant pathway responses in C. elegans by translocating the DAF-16 transcription factor and activation of SOD-3::GFP expression. The Tl+ quantification in worms showed its absorption in the L1 larval stage and bioaccumulation in the body after development.Thallium acetate reduced survival, delayed development, caused behavioral changes, induced responses inherent to oxidative stress, and serious damage to the worm's reproduction. In addition, C. elegans absorbed and bioaccumulated Tl+. Together, our results highlight the impacts of Tl+ exposure in the early stages of life, even for a short period." @default.
• W3195639829 created "2021-08-30" @default.
• W3195639829 creator A5002688073 @default.
• W3195639829 creator A5002826162 @default.
• W3195639829 creator A5005333899 @default.
• W3195639829 creator A5017386049 @default.
• W3195639829 creator A5022551677 @default.
• W3195639829 creator A5027976892 @default.
• W3195639829 creator A5040808104 @default.
• W3195639829 creator A5041890586 @default.
• W3195639829 creator A5049362383 @default.
• W3195639829 creator A5053821121 @default.
• W3195639829 creator A5067096663 @default.
• W3195639829 creator A5069509187 @default.
• W3195639829 creator A5076089199 @default.
• W3195639829 creator A5077576838 @default.
• W3195639829 creator A5089434421 @default.
• W3195639829 date "2021-12-01" @default.
• W3195639829 modified "2023-10-05" @default.
• W3195639829 title "Toxic effects of thallium acetate by acute exposure to the nematode C. elegans" @default.
• W3195639829 cites W1529789394 @default.
• W3195639829 cites W1540119902 @default.
• W3195639829 cites W1570809811 @default.
• W3195639829 cites W1681198552 @default.
• W3195639829 cites W1897817687 @default.
• W3195639829 cites W1944127002 @default.
• W3195639829 cites W1965169890 @default.
• W3195639829 cites W1968314915 @default.
• W3195639829 cites W1971970412 @default.
• W3195639829 cites W1973854983 @default.
• W3195639829 cites W1984944915 @default.
• W3195639829 cites W1997778497 @default.
• W3195639829 cites W2000408838 @default.
• W3195639829 cites W2001592024 @default.
• W3195639829 cites W2002364566 @default.
• W3195639829 cites W2004915936 @default.
• W3195639829 cites W2007188652 @default.
• W3195639829 cites W2017206580 @default.
• W3195639829 cites W2020669463 @default.
• W3195639829 cites W2026931062 @default.
• W3195639829 cites W2033992003 @default.
• W3195639829 cites W2039527951 @default.
• W3195639829 cites W2044904903 @default.
• W3195639829 cites W2048099769 @default.
• W3195639829 cites W2048818452 @default.
• W3195639829 cites W2048857042 @default.
• W3195639829 cites W2054898480 @default.
• W3195639829 cites W2060652221 @default.
• W3195639829 cites W2068343487 @default.
• W3195639829 cites W2070556848 @default.
• W3195639829 cites W2076043361 @default.
• W3195639829 cites W2076792376 @default.
• W3195639829 cites W2080575984 @default.
• W3195639829 cites W2089799301 @default.
• W3195639829 cites W2092111364 @default.
• W3195639829 cites W2099083422 @default.
• W3195639829 cites W2114142468 @default.
• W3195639829 cites W2119126144 @default.
• W3195639829 cites W2129243997 @default.
• W3195639829 cites W2131253137 @default.
• W3195639829 cites W2137827246 @default.
• W3195639829 cites W2144483654 @default.
• W3195639829 cites W2147954736 @default.
• W3195639829 cites W2158769221 @default.
• W3195639829 cites W2164087095 @default.
• W3195639829 cites W2171598875 @default.
• W3195639829 cites W2260652293 @default.
• W3195639829 cites W2293035682 @default.
• W3195639829 cites W2417462381 @default.
• W3195639829 cites W2531278294 @default.
• W3195639829 cites W2589391331 @default.
• W3195639829 cites W2752510460 @default.
• W3195639829 cites W2800406553 @default.
• W3195639829 cites W2809122250 @default.
• W3195639829 cites W2811177841 @default.
• W3195639829 cites W2891321107 @default.
• W3195639829 cites W2895948496 @default.
• W3195639829 cites W2904327934 @default.
• W3195639829 cites W2921540801 @default.
• W3195639829 cites W2955786885 @default.
• W3195639829 cites W2956809915 @default.
• W3195639829 cites W2965193792 @default.
• W3195639829 cites W2965197627 @default.
• W3195639829 cites W2966773878 @default.
• W3195639829 cites W2988745171 @default.
• W3195639829 cites W2990427566 @default.
• W3195639829 cites W2996848303 @default.
• W3195639829 cites W3028739022 @default.
• W3195639829 cites W3084006116 @default.
• W3195639829 cites W4239252007 @default.
• W3195639829 cites W4245378753 @default.
• W3195639829 cites W435488285 @default.
• W3195639829 cites W67735681 @default.
• W3195639829 cites W979746337 @default.
• W3195639829 cites W3089378613 @default.
• W3195639829 doi "https://doi.org/10.1016/j.jtemb.2021.126848" @default.
• W3195639829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34479099" @default.
• W3195639829 hasPublicationYear "2021" @default.

• next