Matches in SemOpenAlex for { <https://semopenalex.org/work/W3195657968> ?p ?o ?g. }
- W3195657968 endingPage "414" @default.
- W3195657968 startingPage "410" @default.
- W3195657968 abstract "Signals from sympathetic neurons and immune cells regulate adipocytes and thereby contribute to fat tissue biology. Interactions between the nervous and immune systems have recently emerged as important regulators of host defence and inflammation1-4. Nevertheless, it is unclear whether neuronal and immune cells co-operate in brain-body axes to orchestrate metabolism and obesity. Here we describe a neuro-mesenchymal unit that controls group 2 innate lymphoid cells (ILC2s), adipose tissue physiology, metabolism and obesity via a brain-adipose circuit. We found that sympathetic nerve terminals act on neighbouring adipose mesenchymal cells via the β2-adrenergic receptor to control the expression of glial-derived neurotrophic factor (GDNF) and the activity of ILC2s in gonadal fat. Accordingly, ILC2-autonomous manipulation of the GDNF receptor machinery led to alterations in ILC2 function, energy expenditure, insulin resistance and propensity to obesity. Retrograde tracing and chemical, surgical and chemogenetic manipulations identified a sympathetic aorticorenal circuit that modulates ILC2s in gonadal fat and connects to higher-order brain areas, including the paraventricular nucleus of the hypothalamus. Our results identify a neuro-mesenchymal unit that translates cues from long-range neuronal circuitry into adipose-resident ILC2 function, thereby shaping host metabolism and obesity." @default.
- W3195657968 created "2021-08-30" @default.
- W3195657968 creator A5011193891 @default.
- W3195657968 creator A5011908260 @default.
- W3195657968 creator A5028109392 @default.
- W3195657968 creator A5049940213 @default.
- W3195657968 creator A5055317786 @default.
- W3195657968 creator A5060670477 @default.
- W3195657968 creator A5064154363 @default.
- W3195657968 creator A5066819826 @default.
- W3195657968 creator A5075429481 @default.
- W3195657968 date "2021-08-18" @default.
- W3195657968 modified "2023-10-14" @default.
- W3195657968 title "Neuro-mesenchymal units control ILC2 and obesity via a brain–adipose circuit" @default.
- W3195657968 cites W1966988179 @default.
- W3195657968 cites W1968517866 @default.
- W3195657968 cites W1972044265 @default.
- W3195657968 cites W1988425215 @default.
- W3195657968 cites W1991845771 @default.
- W3195657968 cites W2002817805 @default.
- W3195657968 cites W2013739762 @default.
- W3195657968 cites W2022161423 @default.
- W3195657968 cites W2023566060 @default.
- W3195657968 cites W2038304451 @default.
- W3195657968 cites W2043072647 @default.
- W3195657968 cites W2043486849 @default.
- W3195657968 cites W2047882259 @default.
- W3195657968 cites W2048233959 @default.
- W3195657968 cites W2053726612 @default.
- W3195657968 cites W2054409862 @default.
- W3195657968 cites W2064068457 @default.
- W3195657968 cites W2064899968 @default.
- W3195657968 cites W2067096633 @default.
- W3195657968 cites W2079570914 @default.
- W3195657968 cites W2080369665 @default.
- W3195657968 cites W2086829762 @default.
- W3195657968 cites W2088102919 @default.
- W3195657968 cites W2088288312 @default.
- W3195657968 cites W2094558708 @default.
- W3195657968 cites W2096394186 @default.
- W3195657968 cites W2096735709 @default.
- W3195657968 cites W2100866502 @default.
- W3195657968 cites W2104135721 @default.
- W3195657968 cites W2130116522 @default.
- W3195657968 cites W2131271579 @default.
- W3195657968 cites W2140489687 @default.
- W3195657968 cites W2158673389 @default.
- W3195657968 cites W2159555560 @default.
- W3195657968 cites W2163470859 @default.
- W3195657968 cites W2169456326 @default.
- W3195657968 cites W2172033467 @default.
- W3195657968 cites W2179438025 @default.
- W3195657968 cites W2252730995 @default.
- W3195657968 cites W2263039862 @default.
- W3195657968 cites W2275332185 @default.
- W3195657968 cites W2292418975 @default.
- W3195657968 cites W2410095089 @default.
- W3195657968 cites W2469014994 @default.
- W3195657968 cites W2514976730 @default.
- W3195657968 cites W2604260273 @default.
- W3195657968 cites W2789630263 @default.
- W3195657968 cites W2794551121 @default.
- W3195657968 cites W2888376450 @default.
- W3195657968 cites W2899194342 @default.
- W3195657968 cites W2912305888 @default.
- W3195657968 cites W2913559606 @default.
- W3195657968 cites W2922506326 @default.
- W3195657968 cites W2942546556 @default.
- W3195657968 cites W2943399314 @default.
- W3195657968 cites W2954371887 @default.
- W3195657968 cites W2973783131 @default.
- W3195657968 cites W2995156818 @default.
- W3195657968 cites W3010819104 @default.
- W3195657968 cites W3091939023 @default.
- W3195657968 doi "https://doi.org/10.1038/s41586-021-03830-7" @default.
- W3195657968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34408322" @default.
- W3195657968 hasPublicationYear "2021" @default.
- W3195657968 type Work @default.
- W3195657968 sameAs 3195657968 @default.
- W3195657968 citedByCount "60" @default.
- W3195657968 countsByYear W31956579682021 @default.
- W3195657968 countsByYear W31956579682022 @default.
- W3195657968 countsByYear W31956579682023 @default.
- W3195657968 crossrefType "journal-article" @default.
- W3195657968 hasAuthorship W3195657968A5011193891 @default.
- W3195657968 hasAuthorship W3195657968A5011908260 @default.
- W3195657968 hasAuthorship W3195657968A5028109392 @default.
- W3195657968 hasAuthorship W3195657968A5049940213 @default.
- W3195657968 hasAuthorship W3195657968A5055317786 @default.
- W3195657968 hasAuthorship W3195657968A5060670477 @default.
- W3195657968 hasAuthorship W3195657968A5064154363 @default.
- W3195657968 hasAuthorship W3195657968A5066819826 @default.
- W3195657968 hasAuthorship W3195657968A5075429481 @default.
- W3195657968 hasBestOaLocation W31956579682 @default.
- W3195657968 hasConcept C126322002 @default.
- W3195657968 hasConcept C134018914 @default.
- W3195657968 hasConcept C160539049 @default.
- W3195657968 hasConcept C169760540 @default.