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• W3195679819 abstract "ObjectiveDeep brain stimulation (DBS) has been used as a treatment of last resort for treatment-resistant depression (TRD) for more than a decade. Many DBS targets have been proposed and tested clinically, but the underlying circuit mechanisms remain unclear. Uncovering white matter tracts (WMT) activated by DBS targets may provide crucial information about the circuit substrates mediating DBS efficacy in ameliorating TRD.MethodsWe performed probabilistic tractography using diffusion magnetic resonance imaging datas from 100 healthy volunteers in Human Connectome Project datasets to analyze the structural connectivity patterns of stimulation targeting currently-used DBS target for TRD. We generated mean and binary fiber distribution maps and calculated the numbers of WMT streamlines in the dataset.ResultsProbabilistic tracking results revealed that activation of distinct DBS targets demonstrated modulation of overlapping but considerably distinct pathways. DBS targets were categorized into 4 groups: Cortical, Striatal, Thalamic, and Medial Forebrain Bundle according to their main modulated WMT and brain areas. Our data also revealed that Brodmann area 10 and amygdala are hub structures that are associated with all DBS targets.ConclusionsOur results together suggest that the distinct mechanism of DBS targets implies individualized target selection and formulation in the future of DBS treatment for TRD. The modulation of Brodmann area 10 and amygdala may be critical for the efficacy of DBS-mediated treatment of TRD." @default.
• W3195679819 created "2021-08-30" @default.
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• W3195679819 date "2021-09-01" @default.
• W3195679819 modified "2023-10-16" @default.
• W3195679819 title "A connectomic analysis of deep brain stimulation for treatment-resistant depression" @default.
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• W3195679819 cites W1944011433 @default.
• W3195679819 cites W1956858973 @default.
• W3195679819 cites W1983485726 @default.
• W3195679819 cites W1997222702 @default.
• W3195679819 cites W1997971699 @default.
• W3195679819 cites W1998096139 @default.
• W3195679819 cites W2000133863 @default.
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• W3195679819 cites W2057435588 @default.
• W3195679819 cites W2080894664 @default.
• W3195679819 cites W2083845601 @default.
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• W3195679819 cites W2131151254 @default.
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• W3195679819 doi "https://doi.org/10.1016/j.brs.2021.08.010" @default.
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