FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3195702961> ?p ?o ?g. }

• W3195702961 endingPage "1669" @default.
• W3195702961 startingPage "1669" @default.
• W3195702961 abstract "The pandemic of COVID-19 caused by SARS-CoV-2 continues to spread despite the global efforts taken to control it. The 3C-like protease (3CLpro), the major protease of SARS-CoV-2, is one of the most interesting targets for antiviral drug development because it is highly conserved among SARS-CoVs and plays an important role in viral replication. Herein, we developed high throughput screening for SARS-CoV-2 3CLpro inhibitor based on AlphaScreen. We screened 91 natural product compounds and found that all-trans retinoic acid (ATRA), an FDA-approved drug, inhibited 3CLpro activity. The 3CLpro inhibitory effect of ATRA was confirmed in vitro by both immunoblotting and AlphaScreen with a 50% inhibition concentration (IC50) of 24.7 ± 1.65 µM. ATRA inhibited the replication of SARS-CoV-2 in VeroE6/TMPRSS2 and Calu-3 cells, with IC50 = 2.69 ± 0.09 µM in the former and 0.82 ± 0.01 µM in the latter. Further, we showed the anti-SARS-CoV-2 effect of ATRA on the currently circulating variants of concern (VOC); alpha, beta, gamma, and delta. These results suggest that ATRA may be considered as a potential therapeutic agent against SARS-CoV-2." @default.
• W3195702961 created "2021-08-30" @default.
• W3195702961 creator A5005056291 @default.
• W3195702961 creator A5019233921 @default.
• W3195702961 creator A5023315457 @default.
• W3195702961 creator A5023657305 @default.
• W3195702961 creator A5052209187 @default.
• W3195702961 creator A5070913984 @default.
• W3195702961 creator A5077444724 @default.
• W3195702961 creator A5081003637 @default.
• W3195702961 creator A5087567079 @default.
• W3195702961 date "2021-08-23" @default.
• W3195702961 modified "2023-10-16" @default.
• W3195702961 title "All-Trans Retinoic Acid Exhibits Antiviral Effect against SARS-CoV-2 by Inhibiting 3CLpro Activity" @default.
• W3195702961 cites W1607326348 @default.
• W3195702961 cites W1748998227 @default.
• W3195702961 cites W1965308726 @default.
• W3195702961 cites W1986986717 @default.
• W3195702961 cites W2005036996 @default.
• W3195702961 cites W2009198965 @default.
• W3195702961 cites W2018506303 @default.
• W3195702961 cites W2027484375 @default.
• W3195702961 cites W2037259928 @default.
• W3195702961 cites W2052499937 @default.
• W3195702961 cites W2056179388 @default.
• W3195702961 cites W2080106148 @default.
• W3195702961 cites W2104617152 @default.
• W3195702961 cites W2134967712 @default.
• W3195702961 cites W2134977065 @default.
• W3195702961 cites W2140187740 @default.
• W3195702961 cites W2156775017 @default.
• W3195702961 cites W2178109946 @default.
• W3195702961 cites W2284201926 @default.
• W3195702961 cites W2336639895 @default.
• W3195702961 cites W3001897055 @default.
• W3195702961 cites W3005212621 @default.
• W3195702961 cites W3010955108 @default.
• W3195702961 cites W3011701533 @default.
• W3195702961 cites W3014962324 @default.
• W3195702961 cites W3015608194 @default.
• W3195702961 cites W3016084006 @default.
• W3195702961 cites W3080596815 @default.
• W3195702961 cites W3081089847 @default.
• W3195702961 cites W3083738738 @default.
• W3195702961 cites W3090929175 @default.
• W3195702961 cites W3098272258 @default.
• W3195702961 cites W3133980772 @default.
• W3195702961 cites W3160235188 @default.
• W3195702961 doi "https://doi.org/10.3390/v13081669" @default.
• W3195702961 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8402917" @default.
• W3195702961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34452533" @default.
• W3195702961 hasPublicationYear "2021" @default.
• W3195702961 type Work @default.
• W3195702961 sameAs 3195702961 @default.
• W3195702961 citedByCount "15" @default.
• W3195702961 countsByYear W31957029612021 @default.
• W3195702961 countsByYear W31957029612022 @default.
• W3195702961 countsByYear W31957029612023 @default.
• W3195702961 crossrefType "journal-article" @default.
• W3195702961 hasAuthorship W3195702961A5005056291 @default.
• W3195702961 hasAuthorship W3195702961A5019233921 @default.
• W3195702961 hasAuthorship W3195702961A5023315457 @default.
• W3195702961 hasAuthorship W3195702961A5023657305 @default.
• W3195702961 hasAuthorship W3195702961A5052209187 @default.
• W3195702961 hasAuthorship W3195702961A5070913984 @default.
• W3195702961 hasAuthorship W3195702961A5077444724 @default.
• W3195702961 hasAuthorship W3195702961A5081003637 @default.
• W3195702961 hasAuthorship W3195702961A5087567079 @default.
• W3195702961 hasBestOaLocation W31957029611 @default.
• W3195702961 hasConcept C104317684 @default.
• W3195702961 hasConcept C140704245 @default.
• W3195702961 hasConcept C142462285 @default.
• W3195702961 hasConcept C159047783 @default.
• W3195702961 hasConcept C181199279 @default.
• W3195702961 hasConcept C185592680 @default.
• W3195702961 hasConcept C202751555 @default.
• W3195702961 hasConcept C2522874641 @default.
• W3195702961 hasConcept C2776714187 @default.
• W3195702961 hasConcept C2777752497 @default.
• W3195702961 hasConcept C2779396153 @default.
• W3195702961 hasConcept C2781121885 @default.
• W3195702961 hasConcept C2781143361 @default.
• W3195702961 hasConcept C2993143319 @default.
• W3195702961 hasConcept C55493867 @default.
• W3195702961 hasConcept C86803240 @default.
• W3195702961 hasConcept C98274493 @default.
• W3195702961 hasConceptScore W3195702961C104317684 @default.
• W3195702961 hasConceptScore W3195702961C140704245 @default.
• W3195702961 hasConceptScore W3195702961C142462285 @default.
• W3195702961 hasConceptScore W3195702961C159047783 @default.
• W3195702961 hasConceptScore W3195702961C181199279 @default.
• W3195702961 hasConceptScore W3195702961C185592680 @default.
• W3195702961 hasConceptScore W3195702961C202751555 @default.
• W3195702961 hasConceptScore W3195702961C2522874641 @default.
• W3195702961 hasConceptScore W3195702961C2776714187 @default.
• W3195702961 hasConceptScore W3195702961C2777752497 @default.
• W3195702961 hasConceptScore W3195702961C2779396153 @default.
• W3195702961 hasConceptScore W3195702961C2781121885 @default.

• next