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• W3195805024 endingPage "108982" @default.
• W3195805024 startingPage "108982" @default.
• W3195805024 abstract "Di-(2-ethylhexyl) phthalate (DEHP) is an endocrine disruptor that causes reproductive defects in male animal models. This study was conducted to explore the plausible modulatory effects of mangiferin (MF) against DEHP-induced testicular injury in rats. Thirty-two adult male albino rats were allocated into four groups. Two groups were given DEHP (2 g/kg/day, p.o) for 14 days. One of these groups was treated with MF (20 mg/kg/day, i.p) for 7 days before and 14 days after DEHP administration. A vehicle-treated control was included, and another group of rats was given MF only. Results revealed that MF treatment suppressed oxidative testicular injury by amplifying the mRNA expression of nuclear factor-erythroid 2 related factor-2 (Nrf2) and increasing hemoxygenase-1 (HO-1), glutathione, and total antioxidant capacity (TAC) levels. This treatment also enhanced superoxide dismutase activity, but it decreased malondialdehyde and nitric oxide levels. MF had an anti-inflammatory characteristic, as demonstrated by the downregulation of the mRNA of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). The content of tumor necrosis factor-alpha also decreased. MF modulated the apoptotic pathway by suppressing the mRNA of cytochrome c (Cyt c), Fas ligand content, Bax IHC expression, caspase-3 activity and cleaved caspase-3 IHC expression. It also upregulated the expression levels of heat-shock protein 70 (HSP70) and B-cell lymphoma 2. Moreover, MF upregulated the mRNA expression levels of HSP70 and c-kit and enriched the content of steroidogenic acute regulatory (StAR) protein, which were reflected in serum testosterone levels. This result indicated that MF played crucial roles in steroidogenesis and spermatogenesis. Besides, the activities of testicular marker enzymes, namely, acid and alkaline phosphatases, and lactate dehydrogenase, significantly increased. Histopathological observations provided evidence supporting the biochemical and molecular measurements. In conclusion, MF provided protective mechanisms against the DEHP-mediated deterioration of testicular functions partially through its antioxidant, anti-inflammatory, and anti-apoptotic properties. It also involved the restoration of steroidogenesis and spermatogenesis through the modulation of Nrf2/HO-1, NF-κB/Cyt c/HSP70, and c-Kit signaling cascades." @default.
• W3195805024 created "2021-08-30" @default.
• W3195805024 creator A5029245620 @default.
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• W3195805024 date "2021-10-01" @default.
• W3195805024 modified "2023-10-16" @default.
• W3195805024 title "Mangiferin mitigates di-(2-ethylhexyl) phthalate-induced testicular injury in rats by modulating oxidative stress-mediated signals, inflammatory cascades, apoptotic pathways, and steroidogenesis" @default.
• W3195805024 cites W1564030416 @default.
• W3195805024 cites W1702179723 @default.
• W3195805024 cites W1876636713 @default.
• W3195805024 cites W1923689774 @default.
• W3195805024 cites W1965026439 @default.
• W3195805024 cites W1969909638 @default.
• W3195805024 cites W1977432060 @default.
• W3195805024 cites W1978546032 @default.
• W3195805024 cites W1981113781 @default.
• W3195805024 cites W1994775963 @default.
• W3195805024 cites W1996064856 @default.
• W3195805024 cites W1999378743 @default.
• W3195805024 cites W2001814144 @default.
• W3195805024 cites W2003004843 @default.
• W3195805024 cites W2008443866 @default.
• W3195805024 cites W2013050119 @default.
• W3195805024 cites W2014044948 @default.
• W3195805024 cites W2016695100 @default.
• W3195805024 cites W2018671017 @default.
• W3195805024 cites W2021738706 @default.
• W3195805024 cites W2023680135 @default.
• W3195805024 cites W2026680892 @default.
• W3195805024 cites W2033882650 @default.
• W3195805024 cites W2035362985 @default.
• W3195805024 cites W2052035877 @default.
• W3195805024 cites W2053054955 @default.
• W3195805024 cites W2053350368 @default.
• W3195805024 cites W2064469489 @default.
• W3195805024 cites W2064886603 @default.
• W3195805024 cites W2065055707 @default.
• W3195805024 cites W2072898133 @default.
• W3195805024 cites W2075190402 @default.
• W3195805024 cites W2078517343 @default.
• W3195805024 cites W2081568627 @default.
• W3195805024 cites W2083165373 @default.
• W3195805024 cites W2085280452 @default.
• W3195805024 cites W2086667809 @default.
• W3195805024 cites W2088454338 @default.
• W3195805024 cites W2088866343 @default.
• W3195805024 cites W2092548402 @default.
• W3195805024 cites W2101400385 @default.
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• W3195805024 cites W2107973910 @default.
• W3195805024 cites W2116236605 @default.
• W3195805024 cites W2121311893 @default.
• W3195805024 cites W2124569198 @default.
• W3195805024 cites W2125734610 @default.
• W3195805024 cites W2126405129 @default.
• W3195805024 cites W2131093877 @default.
• W3195805024 cites W2131850468 @default.
• W3195805024 cites W2131867569 @default.
• W3195805024 cites W2136021032 @default.
• W3195805024 cites W2147856577 @default.
• W3195805024 cites W2168601768 @default.
• W3195805024 cites W2181425336 @default.
• W3195805024 cites W2409747247 @default.
• W3195805024 cites W2464905538 @default.
• W3195805024 cites W2478044326 @default.
• W3195805024 cites W2613535326 @default.
• W3195805024 cites W2799819603 @default.
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• W3195805024 cites W3146726830 @default.
• W3195805024 cites W4253646620 @default.
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• W3195805024 doi "https://doi.org/10.1016/j.abb.2021.108982" @default.
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• W3195805024 hasPublicationYear "2021" @default.
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