FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3195849990> ?p ?o ?g. }

• W3195849990 abstract "Acetylcholinesterase inhibitors (AChEIs) are commonly used to treat mild to moderate cases of Alzheimer disease (AD). To the best of our knowledge, there has been no study estimating the risk of bleeding and cardiovascular events in patients with non-hypertensive AD. Therefore, this study aimed to estimate the association between AChEIs and the risk of bleeding and cardiovascular ischemic events in patients with non-hypertensive AD.A nested case-control study was conducted to estimate the risk of bleeding and ischemic events (angina, myocardial infarction [MI], and stroke) in patients with AD. This study was conducted using the UK Clinical Practice Research Datalink and Hospital Episode Statistics (HES) databases. The study cohort consisted of AD patients ≥65 years of age. The case groups included all AD subjects in the database who had a bleeding or ischemic event during the cohort follow-up. Four controls were selected for each case. Patients were classified as current users or past users based on a 60-day threshold of consuming the drug. Simple and multivariable conditional logistic regression analyses were used to calculate the adjusted odds ratio for bleeding events and cardiovascular events.We identified 507 cases and selected 2028 controls for the bleeding event cohort and 555 cases and 2220 controls for the ischemic event cohort. The adjusted odds ratio (OR) (95% confidence interval [CI]) for the association of AChEI use was 0.93 (0.75 to 1.16) for bleeding events, 2.58 (1.01 to 6.59) for angina, and 1.89 (1.07 to 3.33) for MI. Past users of AChEIs were also at increased risk of stroke (1.51 [1.00 to 2.27]).This is the first study assessing the risk of bleeding and cardiovascular events in patients with non-hypertensive AD. Our findings could be of great interest for clinicians and researchers working on AD." @default.
• W3195849990 created "2021-08-30" @default.
• W3195849990 creator A5024616677 @default.
• W3195849990 creator A5025495911 @default.
• W3195849990 creator A5035567153 @default.
• W3195849990 creator A5040825849 @default.
• W3195849990 creator A5041831769 @default.
• W3195849990 creator A5059182035 @default.
• W3195849990 creator A5085055209 @default.
• W3195849990 creator A5085753944 @default.
• W3195849990 creator A5087116170 @default.
• W3195849990 date "2021-01-01" @default.
• W3195849990 modified "2023-10-01" @default.
• W3195849990 title "Acetylcholinesterase inhibitors and risk of bleeding and acute ischemic events in non‐hypertensive Alzheimer's patients" @default.
• W3195849990 cites W1479723682 @default.
• W3195849990 cites W1523979203 @default.
• W3195849990 cites W1539767705 @default.
• W3195849990 cites W1660970165 @default.
• W3195849990 cites W1775492403 @default.
• W3195849990 cites W1976027331 @default.
• W3195849990 cites W1976825681 @default.
• W3195849990 cites W1992964789 @default.
• W3195849990 cites W1995050909 @default.
• W3195849990 cites W2006922237 @default.
• W3195849990 cites W2042842188 @default.
• W3195849990 cites W2047641191 @default.
• W3195849990 cites W2052834357 @default.
• W3195849990 cites W2065975091 @default.
• W3195849990 cites W2067327439 @default.
• W3195849990 cites W2079396916 @default.
• W3195849990 cites W2087996855 @default.
• W3195849990 cites W2095976219 @default.
• W3195849990 cites W2106585418 @default.
• W3195849990 cites W2119739932 @default.
• W3195849990 cites W2119763231 @default.
• W3195849990 cites W2125348945 @default.
• W3195849990 cites W2126259328 @default.
• W3195849990 cites W2133885791 @default.
• W3195849990 cites W2137419542 @default.
• W3195849990 cites W2144046688 @default.
• W3195849990 cites W2160796563 @default.
• W3195849990 cites W2165828953 @default.
• W3195849990 cites W2167950733 @default.
• W3195849990 cites W2169428949 @default.
• W3195849990 cites W2171576053 @default.
• W3195849990 cites W2179147428 @default.
• W3195849990 cites W2195733756 @default.
• W3195849990 cites W2463406035 @default.
• W3195849990 cites W2464476212 @default.
• W3195849990 cites W260519204 @default.
• W3195849990 cites W2619653998 @default.
• W3195849990 cites W2620167209 @default.
• W3195849990 cites W2749951191 @default.
• W3195849990 cites W2912171184 @default.
• W3195849990 cites W2979908817 @default.
• W3195849990 cites W3024813107 @default.
• W3195849990 cites W3086329702 @default.
• W3195849990 cites W4255426864 @default.
• W3195849990 cites W1987398591 @default.
• W3195849990 doi "https://doi.org/10.1002/trc2.12184" @default.
• W3195849990 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8377777" @default.
• W3195849990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34458554" @default.
• W3195849990 hasPublicationYear "2021" @default.
• W3195849990 type Work @default.
• W3195849990 sameAs 3195849990 @default.
• W3195849990 citedByCount "1" @default.
• W3195849990 countsByYear W31958499902022 @default.
• W3195849990 crossrefType "journal-article" @default.
• W3195849990 hasAuthorship W3195849990A5024616677 @default.
• W3195849990 hasAuthorship W3195849990A5025495911 @default.
• W3195849990 hasAuthorship W3195849990A5035567153 @default.
• W3195849990 hasAuthorship W3195849990A5040825849 @default.
• W3195849990 hasAuthorship W3195849990A5041831769 @default.
• W3195849990 hasAuthorship W3195849990A5059182035 @default.
• W3195849990 hasAuthorship W3195849990A5085055209 @default.
• W3195849990 hasAuthorship W3195849990A5085753944 @default.
• W3195849990 hasAuthorship W3195849990A5087116170 @default.
• W3195849990 hasBestOaLocation W31958499901 @default.
• W3195849990 hasConcept C126322002 @default.
• W3195849990 hasConcept C127413603 @default.
• W3195849990 hasConcept C156957248 @default.
• W3195849990 hasConcept C164705383 @default.
• W3195849990 hasConcept C201903717 @default.
• W3195849990 hasConcept C2777785093 @default.
• W3195849990 hasConcept C2778425758 @default.
• W3195849990 hasConcept C2780645631 @default.
• W3195849990 hasConcept C44249647 @default.
• W3195849990 hasConcept C500558357 @default.
• W3195849990 hasConcept C71924100 @default.
• W3195849990 hasConcept C72563966 @default.
• W3195849990 hasConcept C78519656 @default.
• W3195849990 hasConceptScore W3195849990C126322002 @default.
• W3195849990 hasConceptScore W3195849990C127413603 @default.
• W3195849990 hasConceptScore W3195849990C156957248 @default.
• W3195849990 hasConceptScore W3195849990C164705383 @default.
• W3195849990 hasConceptScore W3195849990C201903717 @default.
• W3195849990 hasConceptScore W3195849990C2777785093 @default.
• W3195849990 hasConceptScore W3195849990C2778425758 @default.
• W3195849990 hasConceptScore W3195849990C2780645631 @default.
• W3195849990 hasConceptScore W3195849990C44249647 @default.

• next