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• W3195889565 abstract "Identify preventive medication treatment response trajectories among youth participating in the Childhood and Adolescent Migraine Prevention study.Data were evaluated from 328 youth (ages 8-17). Childhood and Adolescent Migraine Prevention study participants completed headache diaries during a 28-day baseline period and a 168-day active treatment period during which youth took amitriptyline, topiramate, or placebo. Daily headache occurrence trajectories were established across baseline and active treatment periods using longitudinal hierarchical linear modeling. We tested potential treatment group differences. We also compared final models to trajectory findings from a clinical trial of cognitive behavioral therapy plus amitriptyline for youth with chronic migraine to test for reproducibility.Daily headache occurrence showed stability across baseline. Active treatment models revealed decreases in headache frequency that were most notable early in the trial period. Baseline and active treatment models did not differ by treatment group and replicated trajectory cognitive behavioral therapy plus amitriptyline trial findings.Replicating headache frequency trajectories across clinical trials provides strong evidence that youth can improve quickly. Given no effect for medication, we need to better understand what drives this clinically meaningful improvement. Results also suggest an expected trajectory of treatment response for use in designing and determining endpoints for future clinical trials.Trial Registration. ClinicalTrials.gov Identifier: NCT01581281." @default.
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• W3195889565 date "2021-08-17" @default.
• W3195889565 modified "2023-10-15" @default.
• W3195889565 title "Trajectory of treatment response in the child and adolescent migraine prevention (CHAMP) study: A randomized clinical trial" @default.
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• W3195889565 doi "https://doi.org/10.1177/03331024211033551" @default.
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