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- W3195909819 abstract "NUT carcinoma is an aggressive malignancy characterized by translocations in the NUTM1 gene. There are currently no consensus treatment recommendations for NUT carcinomas.Here, we describe the case of a previously healthy male diagnosed with NUT carcinoma after presenting with sinus pressure, found to have a sinonasal mass and distant metastatic disease in the lungs. While pathologic evaluation and immunohistochemistry were consistent with NUT carcinoma, initial genomic profiling did not demonstrate a NUTM1 translocation.Whole transcriptomic RNA sequencing of the tumor revealed a YAP1-NUTM1 fusion. Based on an in vitro drug sensitivity screen, the patient was treated with gemcitabine and nab-paclitaxel, achieving a partial response that persisted for 9 months.Unbiased transcriptomic sequencing may identify previously uncharacterized NUTM1 fusion partners. Gemcitabine and nab-paclitaxel is a well-tolerated combination chemotherapy regimen and could offer a novel treatment approach for NUT carcinoma." @default.
- W3195909819 created "2021-08-30" @default.
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- W3195909819 date "2021-08-01" @default.
- W3195909819 modified "2023-09-27" @default.
- W3195909819 title "A case of metastatic NUT carcinoma with prolonged response on gemcitabine and nab‐paclitaxel" @default.
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- W3195909819 doi "https://doi.org/10.1002/ccr3.4616" @default.
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