Matches in SemOpenAlex for { <https://semopenalex.org/work/W3195925936> ?p ?o ?g. }
- W3195925936 endingPage "9098" @default.
- W3195925936 startingPage "9098" @default.
- W3195925936 abstract "Protein kinases (PKs) have been recognized as central nervous system (CNS)-disease-relevant targets due to their master regulatory role in different signal transduction cascades in the neuroscience space. Among them, GSK-3β, FYN, and DYRK1A play a crucial role in the neurodegeneration context, and the deregulation of all three PKs has been linked to different CNS disorders with unmet medical needs, including Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal lobar degeneration (FTLD), and several neuromuscular disorders. The multifactorial nature of these diseases, along with the failure of many advanced CNS clinical trials, and the lengthy approval process of a novel CNS drug have strongly limited the CNS drug discovery. However, in the near-decade from 2010 to 2020, several computer-assisted drug design strategies have been combined with synthetic efforts to develop potent and selective GSK-3β, FYN, and DYRK1A inhibitors as disease-modifying agents. In this review, we described both structural and functional aspects of GSK-3β, FYN, and DYRK1A and their involvement and crosstalk in different CNS pathological signaling pathways. Moreover, we outlined attractive medicinal chemistry approaches including multi-target drug design strategies applied to overcome some limitations of known PKs inhibitors and discover improved modulators with suitable blood–brain barrier (BBB) permeability and drug-like properties." @default.
- W3195925936 created "2021-08-30" @default.
- W3195925936 creator A5021953983 @default.
- W3195925936 creator A5022813893 @default.
- W3195925936 creator A5053486985 @default.
- W3195925936 creator A5064920391 @default.
- W3195925936 date "2021-08-23" @default.
- W3195925936 modified "2023-10-11" @default.
- W3195925936 title "GSK-3β, FYN, and DYRK1A: Master Regulators in Neurodegenerative Pathways" @default.
- W3195925936 cites W1042614909 @default.
- W3195925936 cites W1479891216 @default.
- W3195925936 cites W1510447763 @default.
- W3195925936 cites W1513401887 @default.
- W3195925936 cites W1522284801 @default.
- W3195925936 cites W1527750088 @default.
- W3195925936 cites W1608240838 @default.
- W3195925936 cites W168147921 @default.
- W3195925936 cites W1684843658 @default.
- W3195925936 cites W1725757145 @default.
- W3195925936 cites W1773591497 @default.
- W3195925936 cites W1833591189 @default.
- W3195925936 cites W1968542353 @default.
- W3195925936 cites W1969093307 @default.
- W3195925936 cites W1969243451 @default.
- W3195925936 cites W1971304937 @default.
- W3195925936 cites W1973544766 @default.
- W3195925936 cites W1975257189 @default.
- W3195925936 cites W1979694143 @default.
- W3195925936 cites W1979987809 @default.
- W3195925936 cites W1980735023 @default.
- W3195925936 cites W1981913961 @default.
- W3195925936 cites W1982024899 @default.
- W3195925936 cites W1982609777 @default.
- W3195925936 cites W1986503994 @default.
- W3195925936 cites W1986729183 @default.
- W3195925936 cites W1988508701 @default.
- W3195925936 cites W1990626167 @default.
- W3195925936 cites W1993203039 @default.
- W3195925936 cites W1993700689 @default.
- W3195925936 cites W1995346182 @default.
- W3195925936 cites W1995377960 @default.
- W3195925936 cites W1999718232 @default.
- W3195925936 cites W2000088111 @default.
- W3195925936 cites W2000446523 @default.
- W3195925936 cites W2008249867 @default.
- W3195925936 cites W2011032913 @default.
- W3195925936 cites W2011588737 @default.
- W3195925936 cites W2017645489 @default.
- W3195925936 cites W2020676198 @default.
- W3195925936 cites W2021431618 @default.
- W3195925936 cites W2022410893 @default.
- W3195925936 cites W2022532556 @default.
- W3195925936 cites W2023370651 @default.
- W3195925936 cites W2024020573 @default.
- W3195925936 cites W2024262880 @default.
- W3195925936 cites W2026712967 @default.
- W3195925936 cites W2034762925 @default.
- W3195925936 cites W2038582574 @default.
- W3195925936 cites W2040691826 @default.
- W3195925936 cites W2045270516 @default.
- W3195925936 cites W2046822015 @default.
- W3195925936 cites W2048575368 @default.
- W3195925936 cites W2049942764 @default.
- W3195925936 cites W2051603499 @default.
- W3195925936 cites W2058227131 @default.
- W3195925936 cites W2058459224 @default.
- W3195925936 cites W2060241396 @default.
- W3195925936 cites W2070212213 @default.
- W3195925936 cites W2076860508 @default.
- W3195925936 cites W2077951355 @default.
- W3195925936 cites W2079395823 @default.
- W3195925936 cites W2084788321 @default.
- W3195925936 cites W2088028701 @default.
- W3195925936 cites W2088771963 @default.
- W3195925936 cites W2089394160 @default.
- W3195925936 cites W2090013938 @default.
- W3195925936 cites W2090501101 @default.
- W3195925936 cites W2092098171 @default.
- W3195925936 cites W2092785809 @default.
- W3195925936 cites W2100258988 @default.
- W3195925936 cites W2101257013 @default.
- W3195925936 cites W2101725657 @default.
- W3195925936 cites W2112645297 @default.
- W3195925936 cites W2113307391 @default.
- W3195925936 cites W2125726293 @default.
- W3195925936 cites W2125851351 @default.
- W3195925936 cites W2127283584 @default.
- W3195925936 cites W2141354934 @default.
- W3195925936 cites W2143395547 @default.
- W3195925936 cites W2151327886 @default.
- W3195925936 cites W2152705959 @default.
- W3195925936 cites W2153451653 @default.
- W3195925936 cites W2155049938 @default.
- W3195925936 cites W2155836103 @default.
- W3195925936 cites W2158384300 @default.
- W3195925936 cites W2163967054 @default.
- W3195925936 cites W2168175722 @default.
- W3195925936 cites W2172810354 @default.