FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3195937938> ?p ?o ?g. }

• W3195937938 abstract "Mounting evidence has demonstrated the significance of taking microRNAs (miRNAs) as the target of small molecule (SM) drugs for disease treatment. Given the fact that exploring new SM-miRNA associations through biological experiments is extremely expensive, several computing models have been constructed to reveal the possible SM-miRNA associations. Here, we built a computing model of Bounded Nuclear Norm Regularization for SM-miRNA Associations prediction (BNNRSMMA). Specifically, we first constructed a heterogeneous SM-miRNA network utilizing miRNA similarity, SM similarity, confirmed SM-miRNA associations and defined a matrix to represent the heterogeneous network. Then, we constructed a model to complete this matrix by minimizing its nuclear norm. The Alternating Direction Method of Multipliers was adopted to minimize the nuclear norm and obtain predicted scores. The main innovation lies in two aspects. During completion, we limited all elements of the matrix within the interval of (0,1) to make sure they have practical significance. Besides, instead of strictly fitting all known elements, a regularization term was incorporated to tolerate the noise in integrated similarities. Furthermore, four kinds of cross-validations on two datasets and two types of case studies were performed to evaluate the predictive performance of BNNRSMMA. Finally, BNNRSMMA attained areas under the curve of 0.9822 (0.8433), 0.9793 (0.8852), 0.8253 (0.7350) and 0.9758 ± 0.0029 (0.8759 ± 0.0041) under global leave-one-out cross-validation (LOOCV), miRNA-fixed LOOCV, SM-fixed LOOCV and 5-fold cross-validation based on Dataset 1(Dataset 2), respectively. With regard to case studies, plenty of predicted associations have been verified by experimental literatures. All these results confirmed that BNNRSMMA is a reliable tool for inferring associations." @default.
• W3195937938 created "2021-08-30" @default.
• W3195937938 creator A5003562805 @default.
• W3195937938 creator A5004370633 @default.
• W3195937938 creator A5027613930 @default.
• W3195937938 creator A5033532580 @default.
• W3195937938 date "2021-08-18" @default.
• W3195937938 modified "2023-10-15" @default.
• W3195937938 title "Predicting potential small molecule–miRNA associations based on bounded nuclear norm regularization" @default.
• W3195937938 cites W144423133 @default.
• W3195937938 cites W1604827622 @default.
• W3195937938 cites W1889514258 @default.
• W3195937938 cites W1920303762 @default.
• W3195937938 cites W1923876837 @default.
• W3195937938 cites W1967517087 @default.
• W3195937938 cites W1969698720 @default.
• W3195937938 cites W1971744387 @default.
• W3195937938 cites W1975441976 @default.
• W3195937938 cites W1979537657 @default.
• W3195937938 cites W1989921162 @default.
• W3195937938 cites W1992423779 @default.
• W3195937938 cites W1992941735 @default.
• W3195937938 cites W1994399615 @default.
• W3195937938 cites W2007437396 @default.
• W3195937938 cites W2008997396 @default.
• W3195937938 cites W2011359124 @default.
• W3195937938 cites W2013842709 @default.
• W3195937938 cites W2014946489 @default.
• W3195937938 cites W2017394727 @default.
• W3195937938 cites W2039725627 @default.
• W3195937938 cites W2042742026 @default.
• W3195937938 cites W2047071281 @default.
• W3195937938 cites W2047967134 @default.
• W3195937938 cites W2055568666 @default.
• W3195937938 cites W2059958128 @default.
• W3195937938 cites W2067915426 @default.
• W3195937938 cites W2079558799 @default.
• W3195937938 cites W2080424200 @default.
• W3195937938 cites W2086492419 @default.
• W3195937938 cites W2087975583 @default.
• W3195937938 cites W2097226863 @default.
• W3195937938 cites W2103972604 @default.
• W3195937938 cites W2106210472 @default.
• W3195937938 cites W2113072832 @default.
• W3195937938 cites W2123602182 @default.
• W3195937938 cites W2127553917 @default.
• W3195937938 cites W2128768066 @default.
• W3195937938 cites W2130392703 @default.
• W3195937938 cites W2131883344 @default.
• W3195937938 cites W2132093971 @default.
• W3195937938 cites W2137052779 @default.
• W3195937938 cites W2138664009 @default.
• W3195937938 cites W2149385948 @default.
• W3195937938 cites W2153210075 @default.
• W3195937938 cites W2162674813 @default.
• W3195937938 cites W2172153097 @default.
• W3195937938 cites W2203231406 @default.
• W3195937938 cites W2364692879 @default.
• W3195937938 cites W2395168605 @default.
• W3195937938 cites W2443187137 @default.
• W3195937938 cites W2601099694 @default.
• W3195937938 cites W2606619264 @default.
• W3195937938 cites W2765950793 @default.
• W3195937938 cites W2804741160 @default.
• W3195937938 cites W2809893308 @default.
• W3195937938 cites W2810953629 @default.
• W3195937938 cites W2875816355 @default.
• W3195937938 cites W2886514991 @default.
• W3195937938 cites W2896907688 @default.
• W3195937938 cites W2898440040 @default.
• W3195937938 cites W2946952196 @default.
• W3195937938 cites W2960557205 @default.
• W3195937938 cites W3101634756 @default.
• W3195937938 cites W3128269406 @default.
• W3195937938 cites W4212941976 @default.
• W3195937938 cites W4292363360 @default.
• W3195937938 cites W975729763 @default.
• W3195937938 doi "https://doi.org/10.1093/bib/bbab328" @default.
• W3195937938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34404088" @default.
• W3195937938 hasPublicationYear "2021" @default.
• W3195937938 type Work @default.
• W3195937938 sameAs 3195937938 @default.
• W3195937938 citedByCount "38" @default.
• W3195937938 countsByYear W31959379382021 @default.
• W3195937938 countsByYear W31959379382022 @default.
• W3195937938 countsByYear W31959379382023 @default.
• W3195937938 crossrefType "journal-article" @default.
• W3195937938 hasAuthorship W3195937938A5003562805 @default.
• W3195937938 hasAuthorship W3195937938A5004370633 @default.
• W3195937938 hasAuthorship W3195937938A5027613930 @default.
• W3195937938 hasAuthorship W3195937938A5033532580 @default.
• W3195937938 hasConcept C11413529 @default.
• W3195937938 hasConcept C121332964 @default.
• W3195937938 hasConcept C124101348 @default.
• W3195937938 hasConcept C134306372 @default.
• W3195937938 hasConcept C153180895 @default.
• W3195937938 hasConcept C154945302 @default.
• W3195937938 hasConcept C158693339 @default.
• W3195937938 hasConcept C17744445 @default.
• W3195937938 hasConcept C191795146 @default.

• next