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• W3195996828 abstract "Leukemia inhibitory factor (LIF) can influence development by increasing cell proliferation and inhibiting differentiation. Because of its potency for expanding stem cell populations, delivery of exogenous LIF to diseased tissue could have therapeutic value. However, systemic elevations of LIF can have negative, off-target effects. We tested whether inflammatory cells expressing a LIF transgene under control of a leukocyte-specific, CD11b promoter provide a strategy to target LIF to sites of damage in the mdx mouse model of Duchenne muscular dystrophy, leading to increased numbers of muscle stem cells and improved muscle regeneration. However, transgene expression in inflammatory cells did not increase muscle growth or increase numbers of stem cells required for regeneration. Instead, transgene expression disrupted the normal dispersion of macrophages in dystrophic muscles, leading to transient increases in muscle damage in foci where macrophages were highly concentrated during early stages of pathology. The defect in inflammatory cell dispersion reflected impaired chemotaxis of macrophages to C-C motif chemokine ligand-2 and local increases of LIF production that produced large aggregations of cytolytic macrophages. Transgene expression also induced a shift in macrophage phenotype away from a CD206+, M2-biased phenotype that supports regeneration. However, at later stages of the disease when macrophage numbers declined, they dispersed in the muscle, leading to reductions in muscle fiber damage, compared to non-transgenic mdx mice. Together, the findings show that macrophage-mediated delivery of transgenic LIF exerts differential effects on macrophage dispersion and muscle damage depending on the stage of dystrophic pathology." @default.
• W3195996828 created "2021-08-30" @default.
• W3195996828 creator A5004739337 @default.
• W3195996828 creator A5004923097 @default.
• W3195996828 creator A5016017134 @default.
• W3195996828 creator A5025185270 @default.
• W3195996828 date "2021-08-14" @default.
• W3195996828 modified "2023-10-01" @default.
• W3195996828 title "Myeloid cell-mediated targeting of LIF to dystrophic muscle causes transient increases in muscle fiber lesions by disrupting the recruitment and dispersion of macrophages in muscle." @default.
• W3195996828 cites W1539477086 @default.
• W3195996828 cites W1577577364 @default.
• W3195996828 cites W1884465141 @default.
• W3195996828 cites W1963773457 @default.
• W3195996828 cites W1969922725 @default.
• W3195996828 cites W1975375148 @default.
• W3195996828 cites W1975884987 @default.
• W3195996828 cites W1981674166 @default.
• W3195996828 cites W1981708920 @default.
• W3195996828 cites W1983649105 @default.
• W3195996828 cites W1983747690 @default.
• W3195996828 cites W1984437453 @default.
• W3195996828 cites W2000059256 @default.
• W3195996828 cites W2003555720 @default.
• W3195996828 cites W2004790475 @default.
• W3195996828 cites W2007207246 @default.
• W3195996828 cites W2008183439 @default.
• W3195996828 cites W2008869575 @default.
• W3195996828 cites W2012416768 @default.
• W3195996828 cites W2016293419 @default.
• W3195996828 cites W2021472936 @default.
• W3195996828 cites W2025500946 @default.
• W3195996828 cites W2028763115 @default.
• W3195996828 cites W2032519256 @default.
• W3195996828 cites W2037716289 @default.
• W3195996828 cites W2039809246 @default.
• W3195996828 cites W2050354476 @default.
• W3195996828 cites W2058553583 @default.
• W3195996828 cites W2060723028 @default.
• W3195996828 cites W2062520524 @default.
• W3195996828 cites W2078918521 @default.
• W3195996828 cites W2082478076 @default.
• W3195996828 cites W2082584115 @default.
• W3195996828 cites W2088874236 @default.
• W3195996828 cites W2092971257 @default.
• W3195996828 cites W2097384018 @default.
• W3195996828 cites W2098142645 @default.
• W3195996828 cites W2098940221 @default.
• W3195996828 cites W2102009945 @default.
• W3195996828 cites W2102359015 @default.
• W3195996828 cites W2111712137 @default.
• W3195996828 cites W2111718223 @default.
• W3195996828 cites W2112039060 @default.
• W3195996828 cites W2112589767 @default.
• W3195996828 cites W2116476479 @default.
• W3195996828 cites W2123245071 @default.
• W3195996828 cites W2123722127 @default.
• W3195996828 cites W2126792732 @default.
• W3195996828 cites W2128935757 @default.
• W3195996828 cites W2133519004 @default.
• W3195996828 cites W2137312910 @default.
• W3195996828 cites W2142488497 @default.
• W3195996828 cites W2143082806 @default.
• W3195996828 cites W2144067550 @default.
• W3195996828 cites W2144922436 @default.
• W3195996828 cites W2147469412 @default.
• W3195996828 cites W2147678513 @default.
• W3195996828 cites W2148703658 @default.
• W3195996828 cites W2149152441 @default.
• W3195996828 cites W2151457294 @default.
• W3195996828 cites W2153505397 @default.
• W3195996828 cites W2153554828 @default.
• W3195996828 cites W2154192444 @default.
• W3195996828 cites W2157735441 @default.
• W3195996828 cites W2159560463 @default.
• W3195996828 cites W2162019687 @default.
• W3195996828 cites W2163175900 @default.
• W3195996828 cites W2168420558 @default.
• W3195996828 cites W2287603172 @default.
• W3195996828 cites W2337139774 @default.
• W3195996828 cites W2337481972 @default.
• W3195996828 cites W2346451891 @default.
• W3195996828 cites W2523333159 @default.
• W3195996828 cites W2587398364 @default.
• W3195996828 cites W2741175738 @default.
• W3195996828 cites W2761764474 @default.
• W3195996828 cites W2951675934 @default.
• W3195996828 cites W2954997872 @default.
• W3195996828 cites W3062198497 @default.
• W3195996828 cites W4251296644 @default.
• W3195996828 cites W52273448 @default.
• W3195996828 doi "https://doi.org/10.1093/hmg/ddab230" @default.
• W3195996828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34392367" @default.
• W3195996828 hasPublicationYear "2021" @default.
• W3195996828 type Work @default.
• W3195996828 sameAs 3195996828 @default.
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• W3195996828 hasAuthorship W3195996828A5004739337 @default.
• W3195996828 hasAuthorship W3195996828A5004923097 @default.

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