FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196006427> ?p ?o ?g. }

• W3196006427 endingPage "242" @default.
• W3196006427 startingPage "230" @default.
• W3196006427 abstract "The determinants of successful humoral immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of critical importance for the design of effective vaccines and the evaluation of the degree of protective immunity conferred by exposure to the virus. As novel variants emerge, understanding their likelihood of suppression by population antibody repertoires has become increasingly important.In this study, we analyzed the SARS-CoV-2 polyclonal antibody response in a large population of clinically well-characterized patients after mild and severe COVID-19 using a panel of microarrayed structurally folded and unfolded SARS-CoV-2 proteins, as well as sequential peptides, spanning the surface spike protein (S) and the receptor-binding domain (RBD) of the virus.S- and RBD-specific antibody responses were dominated by immunoglobulin G (IgG), mainly IgG1 , and directed against structurally folded S and RBD and three distinct peptide epitopes in S2. The virus neutralization activity of patients´ sera was highly correlated with IgG antibodies specific for conformational but not sequential RBD epitopes and their ability to prevent RBD binding to its human receptor angiotensin-converting enzyme 2 (ACE2). Twenty percent of patients selectively lacked RBD-specific IgG. Only immunization with folded, but not with unfolded RBD, induced antibodies against conformational epitopes with high virus-neutralizing activity. Conformational RBD epitopes required for protection do not seem to be altered in the currently emerging virus variants.These results are fundamental for estimating the protective activity of antibody responses after natural infection or vaccination and for the design of vaccines, which can induce high levels of SARS-CoV-2-neutralizing antibodies conferring sterilizing immunity." @default.
• W3196006427 created "2021-08-30" @default.
• W3196006427 creator A5006733675 @default.
• W3196006427 creator A5009132645 @default.
• W3196006427 creator A5018795290 @default.
• W3196006427 creator A5019980273 @default.
• W3196006427 creator A5025031837 @default.
• W3196006427 creator A5026043898 @default.
• W3196006427 creator A5032680405 @default.
• W3196006427 creator A5034442754 @default.
• W3196006427 creator A5035118066 @default.
• W3196006427 creator A5038469920 @default.
• W3196006427 creator A5040014427 @default.
• W3196006427 creator A5040888641 @default.
• W3196006427 creator A5044586545 @default.
• W3196006427 creator A5046885411 @default.
• W3196006427 creator A5050048947 @default.
• W3196006427 creator A5050176456 @default.
• W3196006427 creator A5054148916 @default.
• W3196006427 creator A5056001172 @default.
• W3196006427 creator A5058657228 @default.
• W3196006427 creator A5059739307 @default.
• W3196006427 creator A5062126351 @default.
• W3196006427 creator A5070621037 @default.
• W3196006427 creator A5073262355 @default.
• W3196006427 creator A5075952320 @default.
• W3196006427 creator A5079844367 @default.
• W3196006427 creator A5080263209 @default.
• W3196006427 creator A5086771679 @default.
• W3196006427 creator A5089938916 @default.
• W3196006427 creator A5090349664 @default.
• W3196006427 date "2021-09-22" @default.
• W3196006427 modified "2023-10-17" @default.
• W3196006427 title "Neutralization of SARS‐CoV‐2 requires antibodies against conformational receptor‐binding domain epitopes" @default.
• W3196006427 cites W1527104786 @default.
• W3196006427 cites W1586051883 @default.
• W3196006427 cites W1789264759 @default.
• W3196006427 cites W1970545997 @default.
• W3196006427 cites W1982533785 @default.
• W3196006427 cites W2054609914 @default.
• W3196006427 cites W2088160623 @default.
• W3196006427 cites W2094893220 @default.
• W3196006427 cites W2099238509 @default.
• W3196006427 cites W2126114330 @default.
• W3196006427 cites W2127421105 @default.
• W3196006427 cites W2130362892 @default.
• W3196006427 cites W2807716735 @default.
• W3196006427 cites W3001118548 @default.
• W3196006427 cites W3021590963 @default.
• W3196006427 cites W3024848554 @default.
• W3196006427 cites W3026872319 @default.
• W3196006427 cites W3037007295 @default.
• W3196006427 cites W3044116551 @default.
• W3196006427 cites W3044660350 @default.
• W3196006427 cites W3045578670 @default.
• W3196006427 cites W3046383041 @default.
• W3196006427 cites W3080937224 @default.
• W3196006427 cites W3084156220 @default.
• W3196006427 cites W3084662547 @default.
• W3196006427 cites W3085955680 @default.
• W3196006427 cites W3086125063 @default.
• W3196006427 cites W3087924281 @default.
• W3196006427 cites W3091214020 @default.
• W3196006427 cites W3092503590 @default.
• W3196006427 cites W3094968263 @default.
• W3196006427 cites W3096319326 @default.
• W3196006427 cites W3096967708 @default.
• W3196006427 cites W3098118792 @default.
• W3196006427 cites W3102905202 @default.
• W3196006427 cites W3112223284 @default.
• W3196006427 cites W3112979595 @default.
• W3196006427 cites W3113305178 @default.
• W3196006427 cites W3113774549 @default.
• W3196006427 cites W3158086491 @default.
• W3196006427 cites W3175011988 @default.
• W3196006427 cites W3196006427 @default.
• W3196006427 doi "https://doi.org/10.1111/all.15066" @default.
• W3196006427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34453317" @default.
• W3196006427 hasPublicationYear "2021" @default.
• W3196006427 type Work @default.
• W3196006427 sameAs 3196006427 @default.
• W3196006427 citedByCount "38" @default.
• W3196006427 countsByYear W31960064272021 @default.
• W3196006427 countsByYear W31960064272022 @default.
• W3196006427 countsByYear W31960064272023 @default.
• W3196006427 crossrefType "journal-article" @default.
• W3196006427 hasAuthorship W3196006427A5006733675 @default.
• W3196006427 hasAuthorship W3196006427A5009132645 @default.
• W3196006427 hasAuthorship W3196006427A5018795290 @default.
• W3196006427 hasAuthorship W3196006427A5019980273 @default.
• W3196006427 hasAuthorship W3196006427A5025031837 @default.
• W3196006427 hasAuthorship W3196006427A5026043898 @default.
• W3196006427 hasAuthorship W3196006427A5032680405 @default.
• W3196006427 hasAuthorship W3196006427A5034442754 @default.
• W3196006427 hasAuthorship W3196006427A5035118066 @default.
• W3196006427 hasAuthorship W3196006427A5038469920 @default.
• W3196006427 hasAuthorship W3196006427A5040014427 @default.
• W3196006427 hasAuthorship W3196006427A5040888641 @default.

• next