FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196013518> ?p ?o ?g. }

• W3196013518 endingPage "e26951" @default.
• W3196013518 startingPage "e26951" @default.
• W3196013518 abstract "An overexpression of S-phase kinase-associated protein 2 (SKP2) is frequently observed in human cancer progression and metastasis, and evidence suggests that SKP2 plays a proto-oncogenic role both in vitro and in vivo. However, the function of SKP2 in gastric adenocarcinoma remains largely obscure. We investigated SKP2 expression in human gastric carcinomas.Tissue samples were acquired from 182 cases of gastric adenocarcinoma that were surgically resected from 2006 to 2012. Immunohistochemical staining for SKP2, Beclin-1, and forkhead box protein P3 (FOXP3) was performed. Pearson chi-square test was used to evaluate the associations among clinicopathological variables. The Kaplan-Meier method, the log-rank test, and the Cox proportional-hazards model were used in the analysis of the overall survival (OS) and disease-free survival (DFS).As a result, SKP2 overexpression in gastric adenocarcinomas showed a significant correlation with several favorable clinical factors, including the tumor size, T category, N category, lymphatic invasion, vascular invasion, OS, and DFS. SKP2 expression was positively correlated with the tumoral FOXP3, Beclin-1 expression, and regulatory T cell (Treg) infiltration. The difference in DFS between the SKP2 positive and negative group was attenuated by FOXP3 high expression, Beclin-1 high expression, and Tregs infiltration. Attenuation of the difference in OS by FOXP3 high expression, Beclin-1 high expression, and Tregs infiltration was not significant. In multivariable analysis, SKP2 expression was not correlated with OS and DFS.Our study showed a complex interrelationship between SKP2 and Beclin-1 and FOXP3 expression in gastric adenocarcinoma. The antioncogenic effect of Beclin-1 and FOXP3 expression in gastric adenocarcinoma is related to SKP2 expression." @default.
• W3196013518 created "2021-08-30" @default.
• W3196013518 creator A5003152491 @default.
• W3196013518 creator A5006365357 @default.
• W3196013518 creator A5088264894 @default.
• W3196013518 date "2021-08-20" @default.
• W3196013518 modified "2023-10-17" @default.
• W3196013518 title "The antioncogenic effect of Beclin-1 and FOXP3 is associated with SKP2 expression in gastric adenocarcinoma" @default.
• W3196013518 cites W1986375034 @default.
• W3196013518 cites W1996965524 @default.
• W3196013518 cites W2014243361 @default.
• W3196013518 cites W2015185783 @default.
• W3196013518 cites W2016316937 @default.
• W3196013518 cites W2022632543 @default.
• W3196013518 cites W2033577259 @default.
• W3196013518 cites W2035828359 @default.
• W3196013518 cites W2037819145 @default.
• W3196013518 cites W2063864717 @default.
• W3196013518 cites W2075296132 @default.
• W3196013518 cites W2078439148 @default.
• W3196013518 cites W2092968008 @default.
• W3196013518 cites W2095370570 @default.
• W3196013518 cites W2109351460 @default.
• W3196013518 cites W2111237964 @default.
• W3196013518 cites W2113935263 @default.
• W3196013518 cites W2122656254 @default.
• W3196013518 cites W2123149440 @default.
• W3196013518 cites W2128640763 @default.
• W3196013518 cites W2137924973 @default.
• W3196013518 cites W2140685830 @default.
• W3196013518 cites W2150678612 @default.
• W3196013518 cites W2160014232 @default.
• W3196013518 cites W2250544263 @default.
• W3196013518 cites W2611446471 @default.
• W3196013518 cites W2625270444 @default.
• W3196013518 cites W2756940672 @default.
• W3196013518 cites W2763064222 @default.
• W3196013518 cites W2769307038 @default.
• W3196013518 cites W2897154408 @default.
• W3196013518 cites W2962275771 @default.
• W3196013518 cites W2994840508 @default.
• W3196013518 cites W3011420121 @default.
• W3196013518 doi "https://doi.org/10.1097/md.0000000000026951" @default.
• W3196013518 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8376310" @default.
• W3196013518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34414959" @default.
• W3196013518 hasPublicationYear "2021" @default.
• W3196013518 type Work @default.
• W3196013518 sameAs 3196013518 @default.
• W3196013518 citedByCount "3" @default.
• W3196013518 countsByYear W31960135182021 @default.
• W3196013518 countsByYear W31960135182022 @default.
• W3196013518 countsByYear W31960135182023 @default.
• W3196013518 crossrefType "journal-article" @default.
• W3196013518 hasAuthorship W3196013518A5003152491 @default.
• W3196013518 hasAuthorship W3196013518A5006365357 @default.
• W3196013518 hasAuthorship W3196013518A5088264894 @default.
• W3196013518 hasBestOaLocation W31960135181 @default.
• W3196013518 hasConcept C104317684 @default.
• W3196013518 hasConcept C10515644 @default.
• W3196013518 hasConcept C121332964 @default.
• W3196013518 hasConcept C121608353 @default.
• W3196013518 hasConcept C126322002 @default.
• W3196013518 hasConcept C134459356 @default.
• W3196013518 hasConcept C142724271 @default.
• W3196013518 hasConcept C143998085 @default.
• W3196013518 hasConcept C153400128 @default.
• W3196013518 hasConcept C203014093 @default.
• W3196013518 hasConcept C204232928 @default.
• W3196013518 hasConcept C25602115 @default.
• W3196013518 hasConcept C2776787872 @default.
• W3196013518 hasConcept C2779013556 @default.
• W3196013518 hasConcept C2779727006 @default.
• W3196013518 hasConcept C2781182431 @default.
• W3196013518 hasConcept C502942594 @default.
• W3196013518 hasConcept C55493867 @default.
• W3196013518 hasConcept C71924100 @default.
• W3196013518 hasConcept C86803240 @default.
• W3196013518 hasConcept C8891405 @default.
• W3196013518 hasConcept C97355855 @default.
• W3196013518 hasConceptScore W3196013518C104317684 @default.
• W3196013518 hasConceptScore W3196013518C10515644 @default.
• W3196013518 hasConceptScore W3196013518C121332964 @default.
• W3196013518 hasConceptScore W3196013518C121608353 @default.
• W3196013518 hasConceptScore W3196013518C126322002 @default.
• W3196013518 hasConceptScore W3196013518C134459356 @default.
• W3196013518 hasConceptScore W3196013518C142724271 @default.
• W3196013518 hasConceptScore W3196013518C143998085 @default.
• W3196013518 hasConceptScore W3196013518C153400128 @default.
• W3196013518 hasConceptScore W3196013518C203014093 @default.
• W3196013518 hasConceptScore W3196013518C204232928 @default.
• W3196013518 hasConceptScore W3196013518C25602115 @default.
• W3196013518 hasConceptScore W3196013518C2776787872 @default.
• W3196013518 hasConceptScore W3196013518C2779013556 @default.
• W3196013518 hasConceptScore W3196013518C2779727006 @default.
• W3196013518 hasConceptScore W3196013518C2781182431 @default.
• W3196013518 hasConceptScore W3196013518C502942594 @default.
• W3196013518 hasConceptScore W3196013518C55493867 @default.
• W3196013518 hasConceptScore W3196013518C71924100 @default.

• next