FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196013805> ?p ?o ?g. }

• W3196013805 endingPage "8" @default.
• W3196013805 startingPage "1" @default.
• W3196013805 abstract "The FKBP5 gene codifies a co-chaperone protein associated with the modulation of glucocorticoid receptor interaction involved in the adaptive stress response. The FKBP5 intracellular concentration affects the binding affinity of the glucocorticoid receptor (GR) to glucocorticoids (GCs). This gene has glucocorticoid response elements (GREs) located in introns 2, 5 and 7, which affect its expression. Recent studies have examined GRE activity and the effects of genetic variants on transcript efficiency and their contribution to susceptibility to behavioral disorders. Epigenetic changes and environmental factors can influence the effects of these allele-specific variants, impacting the response to GCs of the FKBP5 gene. The main epigenetic mark investigated in FKBP5 intronic regions is DNA methylation, however, few studies have been performed for all GREs located in these regions. One of the major findings was the association of low DNA methylation levels in the intron 7 of FKBP5 in patients with psychiatric disorders. To date, there are no reports of DNA methylation in introns 2 and 5 of the gene associated with diagnoses of psychiatric disorders. This review highlights what has been discovered so far about the relationship between polymorphisms and epigenetic targets in intragenic regions, and reveals the gaps that need to be explored, mainly concerning the role of DNA methylation in these regions and how it acts in psychiatric disease susceptibility." @default.
• W3196013805 created "2021-08-30" @default.
• W3196013805 creator A5040199523 @default.
• W3196013805 creator A5041217116 @default.
• W3196013805 creator A5091376437 @default.
• W3196013805 date "2021-11-01" @default.
• W3196013805 modified "2023-09-27" @default.
• W3196013805 title "Regulatory functions of FKBP5 intronic regions associated with psychiatric disorders" @default.
• W3196013805 cites W1093186227 @default.
• W3196013805 cites W1137045498 @default.
• W3196013805 cites W1168447193 @default.
• W3196013805 cites W1547844731 @default.
• W3196013805 cites W1709405361 @default.
• W3196013805 cites W1819987786 @default.
• W3196013805 cites W1900401698 @default.
• W3196013805 cites W1963908055 @default.
• W3196013805 cites W1976502930 @default.
• W3196013805 cites W1977244886 @default.
• W3196013805 cites W1981597300 @default.
• W3196013805 cites W1995724539 @default.
• W3196013805 cites W2011000379 @default.
• W3196013805 cites W2029054759 @default.
• W3196013805 cites W2042074887 @default.
• W3196013805 cites W2043313558 @default.
• W3196013805 cites W2045397061 @default.
• W3196013805 cites W2047534429 @default.
• W3196013805 cites W2055195009 @default.
• W3196013805 cites W2059167203 @default.
• W3196013805 cites W2061084580 @default.
• W3196013805 cites W2063379674 @default.
• W3196013805 cites W2065498897 @default.
• W3196013805 cites W2084403509 @default.
• W3196013805 cites W2101366183 @default.
• W3196013805 cites W2122327012 @default.
• W3196013805 cites W2133924917 @default.
• W3196013805 cites W2142373414 @default.
• W3196013805 cites W2150734066 @default.
• W3196013805 cites W2164393748 @default.
• W3196013805 cites W2179015129 @default.
• W3196013805 cites W2193457910 @default.
• W3196013805 cites W2264731258 @default.
• W3196013805 cites W2300623301 @default.
• W3196013805 cites W2306482506 @default.
• W3196013805 cites W2467813379 @default.
• W3196013805 cites W2511548718 @default.
• W3196013805 cites W2512786904 @default.
• W3196013805 cites W2512946358 @default.
• W3196013805 cites W2756072192 @default.
• W3196013805 cites W2771053654 @default.
• W3196013805 cites W2772534414 @default.
• W3196013805 cites W2793238848 @default.
• W3196013805 cites W2904846549 @default.
• W3196013805 cites W2904946776 @default.
• W3196013805 cites W2905507198 @default.
• W3196013805 cites W2912461836 @default.
• W3196013805 cites W2912696430 @default.
• W3196013805 cites W2920287213 @default.
• W3196013805 cites W2924915101 @default.
• W3196013805 cites W2938203253 @default.
• W3196013805 cites W2951058533 @default.
• W3196013805 cites W2973127841 @default.
• W3196013805 cites W2983680427 @default.
• W3196013805 cites W2988433487 @default.
• W3196013805 cites W2998457908 @default.
• W3196013805 cites W3015973916 @default.
• W3196013805 cites W3022822432 @default.
• W3196013805 cites W3129725165 @default.
• W3196013805 cites W3159301308 @default.
• W3196013805 doi "https://doi.org/10.1016/j.jpsychires.2021.08.014" @default.
• W3196013805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34433110" @default.
• W3196013805 hasPublicationYear "2021" @default.
• W3196013805 type Work @default.
• W3196013805 sameAs 3196013805 @default.
• W3196013805 citedByCount "6" @default.
• W3196013805 countsByYear W31960138052022 @default.
• W3196013805 countsByYear W31960138052023 @default.
• W3196013805 crossrefType "journal-article" @default.
• W3196013805 hasAuthorship W3196013805A5040199523 @default.
• W3196013805 hasAuthorship W3196013805A5041217116 @default.
• W3196013805 hasAuthorship W3196013805A5091376437 @default.
• W3196013805 hasConcept C104317684 @default.
• W3196013805 hasConcept C150194340 @default.
• W3196013805 hasConcept C190727270 @default.
• W3196013805 hasConcept C33288867 @default.
• W3196013805 hasConcept C41091548 @default.
• W3196013805 hasConcept C54355233 @default.
• W3196013805 hasConcept C59493245 @default.
• W3196013805 hasConcept C78150878 @default.
• W3196013805 hasConcept C86803240 @default.
• W3196013805 hasConcept C94671646 @default.
• W3196013805 hasConceptScore W3196013805C104317684 @default.
• W3196013805 hasConceptScore W3196013805C150194340 @default.
• W3196013805 hasConceptScore W3196013805C190727270 @default.
• W3196013805 hasConceptScore W3196013805C33288867 @default.
• W3196013805 hasConceptScore W3196013805C41091548 @default.
• W3196013805 hasConceptScore W3196013805C54355233 @default.
• W3196013805 hasConceptScore W3196013805C59493245 @default.
• W3196013805 hasConceptScore W3196013805C78150878 @default.

• next