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- W3196018552 endingPage "101541" @default.
- W3196018552 startingPage "101541" @default.
- W3196018552 abstract "Disturbances of the sleep/wake cycle in Alzheimer's disease (AD) are common, frequently precede cognitive decline, and tend to worsen with disease progression. Sleep is critical to the maintenance of homeostatic and circadian function, and chronic sleep disturbances have significant cognitive and physical health consequences that likely exacerbate disease severity. Sleep-wake cycles are regulated by neuromodulatory centers located in the brainstem, the hypothalamus, and the basal forebrain, many of which are vulnerable to the accumulation of abnormal protein deposits associated with neurodegenerative conditions. In AD, while sleep disturbances are commonly attributed to the accumulation of amyloid beta, patients often first experience sleep issues prior to the appearance of amyloid beta plaques, on a timeline that more closely corresponds to the first appearance of abnormal tau neurofibrillary tangles in sleep/wake regulating areas of the brainstem. Sleep disturbances also occur in pure tauopathies, providing further support that tau is a major contributor. Here, we provide an overview of the neuroanatomy of sleep/wake centers discovered in animal models, and review the evidence that tau-driven neuropathology is a primary driver of sleep disturbance in AD." @default.
- W3196018552 created "2021-08-30" @default.
- W3196018552 creator A5007938648 @default.
- W3196018552 creator A5037567251 @default.
- W3196018552 creator A5053096250 @default.
- W3196018552 creator A5073522117 @default.
- W3196018552 date "2021-12-01" @default.
- W3196018552 modified "2023-10-17" @default.
- W3196018552 title "Tau-driven degeneration of sleep- and wake-regulating neurons in Alzheimer’s disease" @default.
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