Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196029162> ?p ?o ?g. }
- W3196029162 endingPage "153706" @default.
- W3196029162 startingPage "153706" @default.
- W3196029162 abstract "Hepatocellular carcinoma (HCC) is one of the most common cause of cancer-related death worldwide. Curcumin (C) has been extensively investigated in different types of malignancies, including hepatocellular carcinoma, but its physicochemical properties have significantly influenced its clinical use. Several approaches are being explored to enhance curcumin's therapeutic response, including its combination with various drugs. This study aimed to evaluate the anti-tumor effect of curcumin (C) in combination with F2 (N-n-butyl haloperidol iodide) on hepatocellular carcinoma and its potential underlying mechanism in vitro and in vivo. Cell proliferation was evaluated by CCK-8 and colony formation assays, and apoptosis was measured by flow cytometry. The migratory and invasive abilities of Hep3B and SMMC-7721 cells were measured by wound-healing and matrigel transwell assays. In order to investigate the molecular pathways, various experiments such as western blotting, qPCR, RNA-seq, immunostaining and transfection were performed. To evaluate the anti-HCC effects in vivo, a xenograft tumor model was used. Our findings showed that the combination of curcumin (C) & F2 (F2C) strongly inhibited malignant proliferation and migration in SMMC-7721 and Hep3B cells. The F2C treatment downregulates enhancer of zeste homolog 2 (EZH2) transcription and protein expression, which is key epigenetic regulator responsible for HCC development. Moreover, the inhibition of EZH2 by F2C led to Wnt/β-catenin signaling inhibition by decreasing tri-methylation of histone H3 at lysine 27 (H3K27me3) and long non-coding RNA H19 expression. The inhibition of F2C was associated with the suppression of tumorigenicity in xenograft HCC models. These findings suggested that, F2C inhibited HCC formation, migration and its modulatory mechanism seemed to be associated with downregulation of EZH2, silencing Wnt/β-catenin signaling by interacting with H19, suggesting that F2C may be a promising drug in the clinical treatment of HCC." @default.
- W3196029162 created "2021-08-30" @default.
- W3196029162 creator A5015465130 @default.
- W3196029162 creator A5025070502 @default.
- W3196029162 creator A5025087223 @default.
- W3196029162 creator A5026865772 @default.
- W3196029162 creator A5028269245 @default.
- W3196029162 creator A5051223797 @default.
- W3196029162 creator A5057762207 @default.
- W3196029162 creator A5073521414 @default.
- W3196029162 creator A5080006433 @default.
- W3196029162 date "2021-10-01" @default.
- W3196029162 modified "2023-10-18" @default.
- W3196029162 title "Combination of curcumin with N-n-butyl haloperidol iodide inhibits hepatocellular carcinoma malignant proliferation by downregulating enhancer of zeste homolog 2 (EZH2) - lncRNA H19 to silence Wnt/β-catenin signaling" @default.
- W3196029162 cites W1980937575 @default.
- W3196029162 cites W1982111518 @default.
- W3196029162 cites W1995240381 @default.
- W3196029162 cites W1995652213 @default.
- W3196029162 cites W2025252202 @default.
- W3196029162 cites W2101481061 @default.
- W3196029162 cites W2105154348 @default.
- W3196029162 cites W2133370909 @default.
- W3196029162 cites W2137122561 @default.
- W3196029162 cites W2168089202 @default.
- W3196029162 cites W2329196618 @default.
- W3196029162 cites W2529646902 @default.
- W3196029162 cites W2547035050 @default.
- W3196029162 cites W2579340176 @default.
- W3196029162 cites W2595991151 @default.
- W3196029162 cites W2766830942 @default.
- W3196029162 cites W2793080384 @default.
- W3196029162 cites W2793435411 @default.
- W3196029162 cites W2796494566 @default.
- W3196029162 cites W2797767148 @default.
- W3196029162 cites W2888103445 @default.
- W3196029162 cites W2907978256 @default.
- W3196029162 cites W2928431398 @default.
- W3196029162 cites W2945396862 @default.
- W3196029162 cites W2948525475 @default.
- W3196029162 cites W2969802526 @default.
- W3196029162 cites W3016234622 @default.
- W3196029162 cites W3016238962 @default.
- W3196029162 cites W3032474528 @default.
- W3196029162 cites W3034448267 @default.
- W3196029162 cites W3040033330 @default.
- W3196029162 cites W3046137655 @default.
- W3196029162 cites W3046371893 @default.
- W3196029162 cites W3048297441 @default.
- W3196029162 cites W3089416385 @default.
- W3196029162 cites W3108389912 @default.
- W3196029162 cites W3137955460 @default.
- W3196029162 doi "https://doi.org/10.1016/j.phymed.2021.153706" @default.
- W3196029162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34517264" @default.
- W3196029162 hasPublicationYear "2021" @default.
- W3196029162 type Work @default.
- W3196029162 sameAs 3196029162 @default.
- W3196029162 citedByCount "15" @default.
- W3196029162 countsByYear W31960291622022 @default.
- W3196029162 countsByYear W31960291622023 @default.
- W3196029162 crossrefType "journal-article" @default.
- W3196029162 hasAuthorship W3196029162A5015465130 @default.
- W3196029162 hasAuthorship W3196029162A5025070502 @default.
- W3196029162 hasAuthorship W3196029162A5025087223 @default.
- W3196029162 hasAuthorship W3196029162A5026865772 @default.
- W3196029162 hasAuthorship W3196029162A5028269245 @default.
- W3196029162 hasAuthorship W3196029162A5051223797 @default.
- W3196029162 hasAuthorship W3196029162A5057762207 @default.
- W3196029162 hasAuthorship W3196029162A5073521414 @default.
- W3196029162 hasAuthorship W3196029162A5080006433 @default.
- W3196029162 hasBestOaLocation W31960291621 @default.
- W3196029162 hasConcept C104317684 @default.
- W3196029162 hasConcept C137620995 @default.
- W3196029162 hasConcept C173396325 @default.
- W3196029162 hasConcept C185592680 @default.
- W3196029162 hasConcept C190283241 @default.
- W3196029162 hasConcept C2778250585 @default.
- W3196029162 hasConcept C41091548 @default.
- W3196029162 hasConcept C50171091 @default.
- W3196029162 hasConcept C502942594 @default.
- W3196029162 hasConcept C55493867 @default.
- W3196029162 hasConcept C62112901 @default.
- W3196029162 hasConcept C62478195 @default.
- W3196029162 hasConcept C86803240 @default.
- W3196029162 hasConceptScore W3196029162C104317684 @default.
- W3196029162 hasConceptScore W3196029162C137620995 @default.
- W3196029162 hasConceptScore W3196029162C173396325 @default.
- W3196029162 hasConceptScore W3196029162C185592680 @default.
- W3196029162 hasConceptScore W3196029162C190283241 @default.
- W3196029162 hasConceptScore W3196029162C2778250585 @default.
- W3196029162 hasConceptScore W3196029162C41091548 @default.
- W3196029162 hasConceptScore W3196029162C50171091 @default.
- W3196029162 hasConceptScore W3196029162C502942594 @default.
- W3196029162 hasConceptScore W3196029162C55493867 @default.
- W3196029162 hasConceptScore W3196029162C62112901 @default.
- W3196029162 hasConceptScore W3196029162C62478195 @default.
- W3196029162 hasConceptScore W3196029162C86803240 @default.
- W3196029162 hasFunder F4320321001 @default.
- W3196029162 hasLocation W31960291621 @default.