FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196034892> ?p ?o ?g. }

• W3196034892 abstract "Abstract 2-Fluoroindoles as an important structural scaffold are widely existing in many bioactive or therapeutic agents. Despite their potential usefulness, efficient constructions of 2-fluoroindole derivatives are very sparce. The development of straightforward synthetic approaches to access 2-fluoroindoles is highly desirable for studying their fundamental properties and applications. Herein, we report an efficient and general strategy for the construction of 2-fluoroindoles in which a wide variety of 2-fluoroindoles were accessed with high efficiency and chemoselectivity. Instead of starting from indole skeletons, our strategy constructs indole scaffolds alongside the incorporation of fluorine atom on C2 position in a formal [4+1] cyclization from readily accessible ortho -vinylanilines and difluorocarbene. In our protocol, commercially accessible halodifluoroalkylative reagents provide one carbon and one fluorine atom by cleaving one C-N tertiary bond and forming one C-N bond and one C-C double bond with ortho -vinylanilines. Downstream transformations on 2-fluoroindoles lead to various valuable bioactive molecules which demonstrated significant synthetic advantages over previous reports. And mechanistic studies suggest that the reaction undergoes a cascade difluorocarbene-trapping and intramolecular Michael addition reaction followed by C sp 3 -F bond cleavage." @default.
• W3196034892 created "2021-08-30" @default.
• W3196034892 creator A5005026143 @default.
• W3196034892 creator A5039723441 @default.
• W3196034892 creator A5046591861 @default.
• W3196034892 creator A5063445887 @default.
• W3196034892 creator A5071657898 @default.
• W3196034892 date "2021-08-17" @default.
• W3196034892 modified "2023-10-17" @default.
• W3196034892 title "Difluorocarbene enables to access 2-fluoroindoles from ortho-vinylanilines" @default.
• W3196034892 cites W1983401069 @default.
• W3196034892 cites W1989202995 @default.
• W3196034892 cites W2001421703 @default.
• W3196034892 cites W2033043158 @default.
• W3196034892 cites W2048473711 @default.
• W3196034892 cites W2051013212 @default.
• W3196034892 cites W2076625854 @default.
• W3196034892 cites W2078764239 @default.
• W3196034892 cites W2116087305 @default.
• W3196034892 cites W2116201274 @default.
• W3196034892 cites W2122960188 @default.
• W3196034892 cites W2166743818 @default.
• W3196034892 cites W2240057613 @default.
• W3196034892 cites W2264719596 @default.
• W3196034892 cites W2287992151 @default.
• W3196034892 cites W2323897663 @default.
• W3196034892 cites W2333129245 @default.
• W3196034892 cites W2334883601 @default.
• W3196034892 cites W2404491795 @default.
• W3196034892 cites W2407040666 @default.
• W3196034892 cites W2473622289 @default.
• W3196034892 cites W2528604398 @default.
• W3196034892 cites W2546032191 @default.
• W3196034892 cites W2592421123 @default.
• W3196034892 cites W2602580349 @default.
• W3196034892 cites W2603587510 @default.
• W3196034892 cites W2736545116 @default.
• W3196034892 cites W2754447875 @default.
• W3196034892 cites W2785609333 @default.
• W3196034892 cites W2799879315 @default.
• W3196034892 cites W2803036347 @default.
• W3196034892 cites W2807248496 @default.
• W3196034892 cites W2808072173 @default.
• W3196034892 cites W2808421526 @default.
• W3196034892 cites W2886114224 @default.
• W3196034892 cites W2898324446 @default.
• W3196034892 cites W2907326005 @default.
• W3196034892 cites W2948504986 @default.
• W3196034892 cites W2949250652 @default.
• W3196034892 cites W2950248566 @default.
• W3196034892 cites W2950599579 @default.
• W3196034892 cites W2950933767 @default.
• W3196034892 cites W2952490839 @default.
• W3196034892 cites W2954837889 @default.
• W3196034892 cites W2965941270 @default.
• W3196034892 cites W2973404888 @default.
• W3196034892 cites W3010966446 @default.
• W3196034892 cites W3026453578 @default.
• W3196034892 cites W3055944009 @default.
• W3196034892 cites W3082900205 @default.
• W3196034892 cites W3087148887 @default.
• W3196034892 cites W3095568108 @default.
• W3196034892 cites W3096471324 @default.
• W3196034892 doi "https://doi.org/10.1038/s41467-021-25313-z" @default.
• W3196034892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8371155" @default.
• W3196034892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34404806" @default.
• W3196034892 hasPublicationYear "2021" @default.
• W3196034892 type Work @default.
• W3196034892 sameAs 3196034892 @default.
• W3196034892 citedByCount "24" @default.
• W3196034892 countsByYear W31960348922021 @default.
• W3196034892 countsByYear W31960348922022 @default.
• W3196034892 countsByYear W31960348922023 @default.
• W3196034892 crossrefType "journal-article" @default.
• W3196034892 hasAuthorship W3196034892A5005026143 @default.
• W3196034892 hasAuthorship W3196034892A5039723441 @default.
• W3196034892 hasAuthorship W3196034892A5046591861 @default.
• W3196034892 hasAuthorship W3196034892A5063445887 @default.
• W3196034892 hasAuthorship W3196034892A5071657898 @default.
• W3196034892 hasBestOaLocation W31960348921 @default.
• W3196034892 hasConcept C161790260 @default.
• W3196034892 hasConcept C171250308 @default.
• W3196034892 hasConcept C178790620 @default.
• W3196034892 hasConcept C185592680 @default.
• W3196034892 hasConcept C192527728 @default.
• W3196034892 hasConcept C192562407 @default.
• W3196034892 hasConcept C196099240 @default.
• W3196034892 hasConcept C21951064 @default.
• W3196034892 hasConcept C2777084352 @default.
• W3196034892 hasConcept C3044715 @default.
• W3196034892 hasConcept C40875361 @default.
• W3196034892 hasConcept C506198293 @default.
• W3196034892 hasConcept C68381374 @default.
• W3196034892 hasConcept C71240020 @default.
• W3196034892 hasConcept C75079739 @default.
• W3196034892 hasConceptScore W3196034892C161790260 @default.
• W3196034892 hasConceptScore W3196034892C171250308 @default.
• W3196034892 hasConceptScore W3196034892C178790620 @default.
• W3196034892 hasConceptScore W3196034892C185592680 @default.
• W3196034892 hasConceptScore W3196034892C192527728 @default.

• next