Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196075791> ?p ?o ?g. }
- W3196075791 endingPage "72" @default.
- W3196075791 startingPage "47" @default.
- W3196075791 abstract "Desmosomal cadherins are a recent evolutionary innovation that make up the adhesive core of highly specialized intercellular junctions called desmosomes. Desmosomal cadherins, which are grouped into desmogleins and desmocollins, are related to the classical cadherins, but their cytoplasmic domains are tailored for anchoring intermediate filaments instead of actin to sites of cell-cell adhesion. The resulting junctions are critical for resisting mechanical stress in tissues such as the skin and heart. Desmosomal cadherins also act as signaling hubs that promote differentiation and facilitate morphogenesis, creating more complex and effective tissue barriers in vertebrate tissues. Interference with desmosomal cadherin adhesive and supra-adhesive functions leads to a variety of autoimmune, hereditary, toxin-mediated, and malignant diseases. We review our current understanding of how desmosomal cadherins contribute to human health and disease, highlight gaps in our knowledge about their regulation and function, and introduce promising new directions toward combatting desmosome-related diseases." @default.
- W3196075791 created "2021-08-30" @default.
- W3196075791 creator A5031287976 @default.
- W3196075791 creator A5038495150 @default.
- W3196075791 creator A5085939998 @default.
- W3196075791 creator A5088574888 @default.
- W3196075791 date "2022-01-24" @default.
- W3196075791 modified "2023-10-02" @default.
- W3196075791 title "Desmosomal Cadherins in Health and Disease" @default.
- W3196075791 cites W1560061407 @default.
- W3196075791 cites W1903803659 @default.
- W3196075791 cites W1963765285 @default.
- W3196075791 cites W1965971614 @default.
- W3196075791 cites W1966280773 @default.
- W3196075791 cites W1978543959 @default.
- W3196075791 cites W1980855096 @default.
- W3196075791 cites W1981417550 @default.
- W3196075791 cites W1983025328 @default.
- W3196075791 cites W1988468504 @default.
- W3196075791 cites W1989066034 @default.
- W3196075791 cites W1994984215 @default.
- W3196075791 cites W2002616945 @default.
- W3196075791 cites W2004962670 @default.
- W3196075791 cites W2010922273 @default.
- W3196075791 cites W2010985545 @default.
- W3196075791 cites W2019152596 @default.
- W3196075791 cites W2022204413 @default.
- W3196075791 cites W2023849337 @default.
- W3196075791 cites W2024156824 @default.
- W3196075791 cites W2028766225 @default.
- W3196075791 cites W2032628179 @default.
- W3196075791 cites W2035655881 @default.
- W3196075791 cites W2037385055 @default.
- W3196075791 cites W2040667056 @default.
- W3196075791 cites W2041677910 @default.
- W3196075791 cites W2043535595 @default.
- W3196075791 cites W2043634223 @default.
- W3196075791 cites W2048018833 @default.
- W3196075791 cites W2051037476 @default.
- W3196075791 cites W2051809658 @default.
- W3196075791 cites W2053900926 @default.
- W3196075791 cites W2060373144 @default.
- W3196075791 cites W2060868528 @default.
- W3196075791 cites W2063596531 @default.
- W3196075791 cites W2074313481 @default.
- W3196075791 cites W2076740490 @default.
- W3196075791 cites W2079120806 @default.
- W3196075791 cites W2082715573 @default.
- W3196075791 cites W2085264482 @default.
- W3196075791 cites W2085822999 @default.
- W3196075791 cites W2086576792 @default.
- W3196075791 cites W2092071890 @default.
- W3196075791 cites W2092124228 @default.
- W3196075791 cites W2092506313 @default.
- W3196075791 cites W2094756180 @default.
- W3196075791 cites W2100088353 @default.
- W3196075791 cites W2100510877 @default.
- W3196075791 cites W2103819633 @default.
- W3196075791 cites W2106791166 @default.
- W3196075791 cites W2107129976 @default.
- W3196075791 cites W2107374823 @default.
- W3196075791 cites W2110916958 @default.
- W3196075791 cites W2112715109 @default.
- W3196075791 cites W2116499729 @default.
- W3196075791 cites W2120458577 @default.
- W3196075791 cites W2126014651 @default.
- W3196075791 cites W2128494980 @default.
- W3196075791 cites W2131420230 @default.
- W3196075791 cites W2131700546 @default.
- W3196075791 cites W2133242794 @default.
- W3196075791 cites W2140510507 @default.
- W3196075791 cites W2147166417 @default.
- W3196075791 cites W2150104849 @default.
- W3196075791 cites W2150476862 @default.
- W3196075791 cites W2152256753 @default.
- W3196075791 cites W2152394357 @default.
- W3196075791 cites W2152401146 @default.
- W3196075791 cites W2152661583 @default.
- W3196075791 cites W2154953216 @default.
- W3196075791 cites W2160105296 @default.
- W3196075791 cites W2160737805 @default.
- W3196075791 cites W2161618203 @default.
- W3196075791 cites W2162798818 @default.
- W3196075791 cites W2166487831 @default.
- W3196075791 cites W2169851453 @default.
- W3196075791 cites W2171292347 @default.
- W3196075791 cites W2171724658 @default.
- W3196075791 cites W2172244104 @default.
- W3196075791 cites W2195399807 @default.
- W3196075791 cites W2208030089 @default.
- W3196075791 cites W2345640761 @default.
- W3196075791 cites W2423582682 @default.
- W3196075791 cites W2432757814 @default.
- W3196075791 cites W2519523567 @default.
- W3196075791 cites W2529855985 @default.
- W3196075791 cites W2578370456 @default.
- W3196075791 cites W2592088531 @default.
- W3196075791 cites W2608791215 @default.