FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196076030> ?p ?o ?g. }

• W3196076030 abstract "β2 integrins mediate key processes during leukocyte trafficking. Upon leukocyte activation, the structurally bent β2 integrins change their conformation towards an extended, intermediate and eventually high affinity conformation, which mediate slow leukocyte rolling and firm arrest, respectively. Translocation of talin1 to integrin adhesion sites by interactions with the small GTPase Rap1 and the Rap1 effector Riam precede these processes. Using Rap1 binding mutant talin1 and Riam deficient mice we show a strong Riam-dependent T cell homing process to lymph nodes in adoptive transfer experiments and by intravital microscopy. Moreover, neutrophils from compound mutant mice exhibit strongly increased rolling velocities to inflamed cremaster muscle venules compared to single mutants. Using Hoxb8 cell derived neutrophils generated from the mutant mouse strains, we show that both pathways regulate leukocyte rolling and adhesion synergistically by inducing conformational changes of the β2 integrin ectodomain. Importantly, a simultaneous loss of both pathways results in a rolling phenotype similar to talin1 deficient neutrophils suggesting that β2 integrin regulation primarily occurs via these two pathways." @default.
• W3196076030 created "2021-08-30" @default.
• W3196076030 creator A5000137109 @default.
• W3196076030 creator A5018260304 @default.
• W3196076030 creator A5019612964 @default.
• W3196076030 creator A5019837931 @default.
• W3196076030 creator A5021389980 @default.
• W3196076030 creator A5035451949 @default.
• W3196076030 creator A5060011272 @default.
• W3196076030 creator A5063732018 @default.
• W3196076030 creator A5066251778 @default.
• W3196076030 creator A5078366134 @default.
• W3196076030 creator A5083473328 @default.
• W3196076030 date "2021-08-19" @default.
• W3196076030 modified "2023-09-26" @default.
• W3196076030 title "Binding of Rap1 and Riam to Talin1 Fine-Tune β2 Integrin Activity During Leukocyte Trafficking" @default.
• W3196076030 cites W1262336387 @default.
• W3196076030 cites W1745881199 @default.
• W3196076030 cites W1964265166 @default.
• W3196076030 cites W1966302652 @default.
• W3196076030 cites W1978467398 @default.
• W3196076030 cites W1995553619 @default.
• W3196076030 cites W2005532545 @default.
• W3196076030 cites W2025069371 @default.
• W3196076030 cites W2032348507 @default.
• W3196076030 cites W2035809865 @default.
• W3196076030 cites W2036285528 @default.
• W3196076030 cites W2039502415 @default.
• W3196076030 cites W2048520623 @default.
• W3196076030 cites W2058624823 @default.
• W3196076030 cites W2067528927 @default.
• W3196076030 cites W2092065925 @default.
• W3196076030 cites W2102637482 @default.
• W3196076030 cites W2108496308 @default.
• W3196076030 cites W2125678362 @default.
• W3196076030 cites W2131993766 @default.
• W3196076030 cites W2161659314 @default.
• W3196076030 cites W2162005182 @default.
• W3196076030 cites W2168539398 @default.
• W3196076030 cites W2169811294 @default.
• W3196076030 cites W2170176013 @default.
• W3196076030 cites W2230622696 @default.
• W3196076030 cites W2272040821 @default.
• W3196076030 cites W2734694910 @default.
• W3196076030 cites W2770325190 @default.
• W3196076030 cites W2886453020 @default.
• W3196076030 cites W2891017215 @default.
• W3196076030 cites W2891524470 @default.
• W3196076030 cites W2893450916 @default.
• W3196076030 cites W2901206051 @default.
• W3196076030 cites W2901644785 @default.
• W3196076030 cites W2939943074 @default.
• W3196076030 cites W2945567049 @default.
• W3196076030 cites W2977532329 @default.
• W3196076030 cites W3033905875 @default.
• W3196076030 cites W3094477456 @default.
• W3196076030 doi "https://doi.org/10.3389/fimmu.2021.702345" @default.
• W3196076030 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8417109" @default.
• W3196076030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34489950" @default.
• W3196076030 hasPublicationYear "2021" @default.
• W3196076030 type Work @default.
• W3196076030 sameAs 3196076030 @default.
• W3196076030 citedByCount "12" @default.
• W3196076030 countsByYear W31960760302022 @default.
• W3196076030 countsByYear W31960760302023 @default.
• W3196076030 crossrefType "journal-article" @default.
• W3196076030 hasAuthorship W3196076030A5000137109 @default.
• W3196076030 hasAuthorship W3196076030A5018260304 @default.
• W3196076030 hasAuthorship W3196076030A5019612964 @default.
• W3196076030 hasAuthorship W3196076030A5019837931 @default.
• W3196076030 hasAuthorship W3196076030A5021389980 @default.
• W3196076030 hasAuthorship W3196076030A5035451949 @default.
• W3196076030 hasAuthorship W3196076030A5060011272 @default.
• W3196076030 hasAuthorship W3196076030A5063732018 @default.
• W3196076030 hasAuthorship W3196076030A5066251778 @default.
• W3196076030 hasAuthorship W3196076030A5078366134 @default.
• W3196076030 hasAuthorship W3196076030A5083473328 @default.
• W3196076030 hasBestOaLocation W31960760301 @default.
• W3196076030 hasConcept C1009742 @default.
• W3196076030 hasConcept C104317684 @default.
• W3196076030 hasConcept C13373296 @default.
• W3196076030 hasConcept C143065580 @default.
• W3196076030 hasConcept C1491633281 @default.
• W3196076030 hasConcept C170493617 @default.
• W3196076030 hasConcept C185592680 @default.
• W3196076030 hasConcept C195687474 @default.
• W3196076030 hasConcept C2776179587 @default.
• W3196076030 hasConcept C2910341952 @default.
• W3196076030 hasConcept C55493867 @default.
• W3196076030 hasConcept C62478195 @default.
• W3196076030 hasConcept C85789140 @default.
• W3196076030 hasConcept C86803240 @default.
• W3196076030 hasConcept C95444343 @default.
• W3196076030 hasConceptScore W3196076030C1009742 @default.
• W3196076030 hasConceptScore W3196076030C104317684 @default.
• W3196076030 hasConceptScore W3196076030C13373296 @default.
• W3196076030 hasConceptScore W3196076030C143065580 @default.
• W3196076030 hasConceptScore W3196076030C1491633281 @default.
• W3196076030 hasConceptScore W3196076030C170493617 @default.
• W3196076030 hasConceptScore W3196076030C185592680 @default.

• next