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- W3196085412 abstract "Inflammatory arthritis (IA) is a common disease that affects millions of individuals worldwide. Proinflammatory events during IA pathogenesis are well studied; however, loss of protective immunity remains underexplored. Earlier, we reported that 14-3-3zeta (ζ) has a role in T-cell polarization and interleukin (IL)-17A signal transduction. Here, we demonstrate that 14-3-3ζ knockout (KO) rats develop early-onset severe arthritis in two independent models of IA, pristane-induced arthritis and collagen-induced arthritis. Arthritic 14-3-3ζ KO animals showed an increase in bone loss and immune cell infiltration in synovial joints. Induction of arthritis coincided with the loss of anti-14-3-3ζ antibodies; however, rescue experiments to supplement the 14-3-3ζ antibody by passive immunization did not suppress arthritis. Instead, 14-3-3ζ immunization during the presymptomatic phase resulted in significant suppression of arthritis in both wild-type and 14-3-3ζ KO animals. Mechanistically, 14-3-3ζ KO rats exhibited elevated inflammatory gene signatures at the messenger RNA and protein levels, particularly for IL-1β. Furthermore, the immunization with recombinant 14-3-3ζ protein suppressed IL-1β levels, significantly increased anti-14-3-3ζ antibody levels and collagen production, and preserved bone quality. The 14-3-3ζ protein increased collagen expression in primary rat mesenchymal cells. Together, our findings indicate that 14-3-3ζ causes immune suppression and extracellular remodeling, which lead to a previously unrecognized IA-suppressive function." @default.
- W3196085412 created "2021-08-30" @default.
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- W3196085412 date "2021-08-18" @default.
- W3196085412 modified "2023-10-13" @default.
- W3196085412 title "14-3-3ζ: A suppressor of inflammatory arthritis" @default.
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- W3196085412 doi "https://doi.org/10.1073/pnas.2025257118" @default.
- W3196085412 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8403930" @default.
- W3196085412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34408018" @default.
- W3196085412 hasPublicationYear "2021" @default.
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