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- W3196091337 abstract "Abstract Multiple organ dysfunction is the most severe outcome of sepsis progression and is highly correlated with a worse prognosis. Excessive neutrophil extracellular traps (NETs) are critical players in the development of organ failure during sepsis. Therefore, interventions targeting NET release would likely effectively prevent NET-based organ injury associated with this disease. Herein, we demonstrate that the pore-forming protein gasdermin D (GSDMD) is active in neutrophils from septic humans and mice and plays a crucial role in NET release. Inhibition of GSDMD with disulfiram or genic deletion abrogated NET formation, reducing multiple organ dysfunction and sepsis lethality. Mechanistically, we demonstrate that during sepsis, activation of the caspase-11/GSDMD pathway controls NET release by neutrophils during sepsis. In summary, our findings uncover a novel therapeutic use for disulfiram and suggest that GSDMD is a therapeutic target to improve sepsis treatment." @default.
- W3196091337 created "2021-08-30" @default.
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- W3196091337 date "2021-12-23" @default.
- W3196091337 modified "2023-10-12" @default.
- W3196091337 title "Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blocking NET formation" @default.
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- W3196091337 cites W2032227357 @default.
- W3196091337 cites W2032733408 @default.
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- W3196091337 cites W2177407033 @default.
- W3196091337 cites W2257342069 @default.
- W3196091337 cites W2280404143 @default.
- W3196091337 cites W2281572360 @default.
- W3196091337 cites W2418822219 @default.
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- W3196091337 cites W2766905006 @default.
- W3196091337 cites W2777665100 @default.
- W3196091337 cites W2792307022 @default.
- W3196091337 cites W2808965517 @default.
- W3196091337 cites W2888168693 @default.
- W3196091337 cites W2888725678 @default.
- W3196091337 cites W2891921191 @default.
- W3196091337 cites W2942444134 @default.
- W3196091337 cites W2952514272 @default.
- W3196091337 cites W2967725497 @default.
- W3196091337 cites W2994381342 @default.
- W3196091337 cites W3000146621 @default.
- W3196091337 cites W3004238134 @default.
- W3196091337 cites W3009049647 @default.
- W3196091337 cites W3018507926 @default.
- W3196091337 cites W3022981886 @default.
- W3196091337 cites W3031005545 @default.
- W3196091337 cites W3033024816 @default.
- W3196091337 cites W3085958090 @default.
- W3196091337 cites W3092394475 @default.
- W3196091337 cites W3158550505 @default.
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- W3196091337 doi "https://doi.org/10.1182/blood.2021011525" @default.
- W3196091337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34407544" @default.
- W3196091337 hasPublicationYear "2021" @default.
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