Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196151055> ?p ?o ?g. }
- W3196151055 endingPage "103385" @default.
- W3196151055 startingPage "103385" @default.
- W3196151055 abstract "COVID-19 is an ongoing viral pandemic produced by SARS-CoV-2. In light of in vitro efficacy, several medications were repurposed for its management. During clinical use, many of these medications produced inconsistent results or had varying limitations.The purpose of this literature review is to explain the variable efficacy or limitations of Lopinavir/Ritonavir, Remdesivir, Hydroxychloroquine, and Favipiravir in clinical settings.A study of the literature on the pharmacodynamics (PD), pharmacokinetics (PK), safety profile, and clinical trials through academic databases using relevant search terms.The efficacy of an antiviral drug against COVID-19 is associated with its ability to achieve therapeutic concentration in the lung and intestinal tissues. This efficacy depends on the PK properties, particularly protein binding, volume of distribution, and half-life. The PK and PD of the model drugs need to be integrated to predict their limitations.Current antiviral drugs have varying pharmacological constraints that may associate with limited efficacy, especially in severe COVID-19 patients, or safety concerns." @default.
- W3196151055 created "2021-08-30" @default.
- W3196151055 creator A5003420789 @default.
- W3196151055 creator A5008604909 @default.
- W3196151055 creator A5008829126 @default.
- W3196151055 creator A5051427332 @default.
- W3196151055 creator A5055047243 @default.
- W3196151055 creator A5056893159 @default.
- W3196151055 creator A5061884107 @default.
- W3196151055 date "2021-10-01" @default.
- W3196151055 modified "2023-10-10" @default.
- W3196151055 title "Scoping insight on antiviral drugs against COVID-19" @default.
- W3196151055 cites W1542749189 @default.
- W3196151055 cites W2017028699 @default.
- W3196151055 cites W2035610264 @default.
- W3196151055 cites W2074364974 @default.
- W3196151055 cites W2100967823 @default.
- W3196151055 cites W2268078935 @default.
- W3196151055 cites W2510215871 @default.
- W3196151055 cites W2580356750 @default.
- W3196151055 cites W2589138774 @default.
- W3196151055 cites W2739679816 @default.
- W3196151055 cites W2884931273 @default.
- W3196151055 cites W2911505242 @default.
- W3196151055 cites W2996911401 @default.
- W3196151055 cites W3004709581 @default.
- W3196151055 cites W3005212621 @default.
- W3196151055 cites W3007969569 @default.
- W3196151055 cites W3008090866 @default.
- W3196151055 cites W3008510500 @default.
- W3196151055 cites W3008763357 @default.
- W3196151055 cites W3008962515 @default.
- W3196151055 cites W3009577418 @default.
- W3196151055 cites W3010611713 @default.
- W3196151055 cites W3010930696 @default.
- W3196151055 cites W3011603843 @default.
- W3196151055 cites W3011779988 @default.
- W3196151055 cites W3012455685 @default.
- W3196151055 cites W3012702001 @default.
- W3196151055 cites W3013460037 @default.
- W3196151055 cites W3014203610 @default.
- W3196151055 cites W3014426942 @default.
- W3196151055 cites W3015136197 @default.
- W3196151055 cites W3015490759 @default.
- W3196151055 cites W3015708777 @default.
- W3196151055 cites W3016084006 @default.
- W3196151055 cites W3016147039 @default.
- W3196151055 cites W3016155698 @default.
- W3196151055 cites W3016626550 @default.
- W3196151055 cites W3019170348 @default.
- W3196151055 cites W3020322445 @default.
- W3196151055 cites W3022076281 @default.
- W3196151055 cites W3022373008 @default.
- W3196151055 cites W3022402198 @default.
- W3196151055 cites W3023365912 @default.
- W3196151055 cites W3023911418 @default.
- W3196151055 cites W3023915741 @default.
- W3196151055 cites W3025167304 @default.
- W3196151055 cites W3026626432 @default.
- W3196151055 cites W3026711303 @default.
- W3196151055 cites W3026803444 @default.
- W3196151055 cites W3026954076 @default.
- W3196151055 cites W3027751515 @default.
- W3196151055 cites W3027858755 @default.
- W3196151055 cites W3028296069 @default.
- W3196151055 cites W3028772421 @default.
- W3196151055 cites W3028773854 @default.
- W3196151055 cites W3029741935 @default.
- W3196151055 cites W3030307047 @default.
- W3196151055 cites W3033420401 @default.
- W3196151055 cites W3033655487 @default.
- W3196151055 cites W3036716737 @default.
- W3196151055 cites W3036749055 @default.
- W3196151055 cites W3036853141 @default.
- W3196151055 cites W3038814558 @default.
- W3196151055 cites W3041789758 @default.
- W3196151055 cites W3041968020 @default.
- W3196151055 cites W3042586703 @default.
- W3196151055 cites W3042832159 @default.
- W3196151055 cites W3043084992 @default.
- W3196151055 cites W3043241379 @default.
- W3196151055 cites W3046717686 @default.
- W3196151055 cites W3047197438 @default.
- W3196151055 cites W3047565267 @default.
- W3196151055 cites W3048018942 @default.
- W3196151055 cites W3050041722 @default.
- W3196151055 cites W3081640332 @default.
- W3196151055 cites W3083912845 @default.
- W3196151055 cites W3085050275 @default.
- W3196151055 cites W3086308305 @default.
- W3196151055 cites W3086472839 @default.
- W3196151055 cites W3089908609 @default.
- W3196151055 cites W3090096029 @default.
- W3196151055 cites W3090836418 @default.
- W3196151055 cites W3090929175 @default.
- W3196151055 cites W3093687230 @default.
- W3196151055 cites W3095117046 @default.
- W3196151055 cites W3095200173 @default.