FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196156768> ?p ?o ?g. }

• W3196156768 endingPage "e07845" @default.
• W3196156768 startingPage "e07845" @default.
• W3196156768 abstract "Liver injury caused by ischemia reperfusion (I/R) during surgical procedures, such as liver resection or liver transplantation, is a major cause of liver damage and graft failure. The current method of treatment is mostly preventative (i.e., ischemic preconditioning). While a number of pharmacological modalities have been studied to reduce hepatic I/R injury, none have been entirely successful. It has been demonstrated that the administration of adrenomedullin (AM) in combination with AM-binding protein (AM/AMBP-1) exerts significant protective effects in various pathological conditions. In an effort to develop AM/AMBP-1 as a novel therapeutic for hepatic I/R injury, the present study examined the effect of a low dose of human AM, which does not induce hypotension, in combination with human AMBP-1 in a rabbit model of hepatic I/R (i.e., non-rodent species).Ischemia of 70% of the liver was induced by placing a microvascular clip across the hilum of the left and median lobes for 60 min. The clip was then removed to commence reperfusion. At 15 min following clip removal (i.e., reperfusion), human AM/AMBP-1 was administered intravenously via the ear marginal vein continuously for 30 min. At 20 h, blood and tissue samples were collected for various measurements.The serum levels of liver enzymes (alanine aminotransferase and aspartate aminotransferase) and lactate dehydrogenase, were elevated following hepatic I/R. The administration of AM/AMBP-1 significantly decreased these levels by 58, 44, 41%, respectively. Hepatic I/R increased the direct and total bilirubin levels, whereas treatment with human AM/AMBP-1 decreased these levels by 60% and 69%, respectively. Treatment with AM/AMBP-1 also inhibited interleukin-6 gene expression by 95%. There were no changes in tumor necrosis factor-α (TNF-α) gene expression and myeloperoxidase activity (MPO), lactate and Suzuki scores after treatment. The treatment, however, reduced apoptosis post-hepatic I/R in the ischemic portion of the liver.Additional experiments with AM and AMBP-1 alone are needed to completely interpret the experimental results in this non-rodent species of hepatic I/R injury. The present study suggests that human AM/AMBP-1 may be developed as a novel therapeutic to attenuate hepatic I/R associated inflammation and liver injury." @default.
• W3196156768 created "2021-08-30" @default.
• W3196156768 creator A5013736647 @default.
• W3196156768 creator A5040367379 @default.
• W3196156768 creator A5050855271 @default.
• W3196156768 creator A5091109988 @default.
• W3196156768 date "2021-08-01" @default.
• W3196156768 modified "2023-09-24" @default.
• W3196156768 title "Human adrenomedullin and its binding protein attenuate tissue injury and inflammation following hepatic ischemia reperfusion in rabbits" @default.
• W3196156768 cites W1522155977 @default.
• W3196156768 cites W1798785183 @default.
• W3196156768 cites W1836532169 @default.
• W3196156768 cites W1969830999 @default.
• W3196156768 cites W1976081136 @default.
• W3196156768 cites W1991360122 @default.
• W3196156768 cites W1994174891 @default.
• W3196156768 cites W1996115257 @default.
• W3196156768 cites W1996393316 @default.
• W3196156768 cites W2002035262 @default.
• W3196156768 cites W2013316820 @default.
• W3196156768 cites W2019164853 @default.
• W3196156768 cites W2031448393 @default.
• W3196156768 cites W2036662072 @default.
• W3196156768 cites W2039113406 @default.
• W3196156768 cites W2040558515 @default.
• W3196156768 cites W2041669340 @default.
• W3196156768 cites W2046432740 @default.
• W3196156768 cites W2050475327 @default.
• W3196156768 cites W2051576182 @default.
• W3196156768 cites W2077603081 @default.
• W3196156768 cites W2092419989 @default.
• W3196156768 cites W2094794731 @default.
• W3196156768 cites W2094994911 @default.
• W3196156768 cites W2102374492 @default.
• W3196156768 cites W2107277218 @default.
• W3196156768 cites W2107761713 @default.
• W3196156768 cites W2115361985 @default.
• W3196156768 cites W2137722282 @default.
• W3196156768 cites W2139232589 @default.
• W3196156768 cites W2157454255 @default.
• W3196156768 cites W2192080449 @default.
• W3196156768 cites W2221381460 @default.
• W3196156768 cites W2544397718 @default.
• W3196156768 cites W2557915016 @default.
• W3196156768 cites W2561288668 @default.
• W3196156768 cites W2783073608 @default.
• W3196156768 cites W2906288826 @default.
• W3196156768 cites W2907436115 @default.
• W3196156768 cites W2973962175 @default.
• W3196156768 cites W793215958 @default.
• W3196156768 doi "https://doi.org/10.1016/j.heliyon.2021.e07845" @default.
• W3196156768 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8391051" @default.
• W3196156768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34485732" @default.
• W3196156768 hasPublicationYear "2021" @default.
• W3196156768 type Work @default.
• W3196156768 sameAs 3196156768 @default.
• W3196156768 citedByCount "1" @default.
• W3196156768 countsByYear W31961567682023 @default.
• W3196156768 crossrefType "journal-article" @default.
• W3196156768 hasAuthorship W3196156768A5013736647 @default.
• W3196156768 hasAuthorship W3196156768A5040367379 @default.
• W3196156768 hasAuthorship W3196156768A5050855271 @default.
• W3196156768 hasAuthorship W3196156768A5091109988 @default.
• W3196156768 hasBestOaLocation W31961567681 @default.
• W3196156768 hasConcept C126322002 @default.
• W3196156768 hasConcept C142724271 @default.
• W3196156768 hasConcept C170493617 @default.
• W3196156768 hasConcept C181199279 @default.
• W3196156768 hasConcept C2776637226 @default.
• W3196156768 hasConcept C2777152744 @default.
• W3196156768 hasConcept C2777318727 @default.
• W3196156768 hasConcept C2779609443 @default.
• W3196156768 hasConcept C2780114680 @default.
• W3196156768 hasConcept C2911091166 @default.
• W3196156768 hasConcept C541997718 @default.
• W3196156768 hasConcept C55493867 @default.
• W3196156768 hasConcept C71924100 @default.
• W3196156768 hasConcept C86803240 @default.
• W3196156768 hasConcept C98274493 @default.
• W3196156768 hasConceptScore W3196156768C126322002 @default.
• W3196156768 hasConceptScore W3196156768C142724271 @default.
• W3196156768 hasConceptScore W3196156768C170493617 @default.
• W3196156768 hasConceptScore W3196156768C181199279 @default.
• W3196156768 hasConceptScore W3196156768C2776637226 @default.
• W3196156768 hasConceptScore W3196156768C2777152744 @default.
• W3196156768 hasConceptScore W3196156768C2777318727 @default.
• W3196156768 hasConceptScore W3196156768C2779609443 @default.
• W3196156768 hasConceptScore W3196156768C2780114680 @default.
• W3196156768 hasConceptScore W3196156768C2911091166 @default.
• W3196156768 hasConceptScore W3196156768C541997718 @default.
• W3196156768 hasConceptScore W3196156768C55493867 @default.
• W3196156768 hasConceptScore W3196156768C71924100 @default.
• W3196156768 hasConceptScore W3196156768C86803240 @default.
• W3196156768 hasConceptScore W3196156768C98274493 @default.
• W3196156768 hasFunder F4320332161 @default.
• W3196156768 hasFunder F4320337338 @default.
• W3196156768 hasIssue "8" @default.
• W3196156768 hasLocation W31961567681 @default.

• next