FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196190746> ?p ?o ?g. }

• W3196190746 endingPage "109006" @default.
• W3196190746 startingPage "109006" @default.
• W3196190746 abstract "Molecules inhibiting the amyloid beta (Aβ) peptide aggregation and/or disaggregating mature fibrils are a promising approach for the Alzheimer's disease (AD) therapy, as the Aβ fibrillation is one of the key triggers of the disease. Gallic acid (GA) is a phenolic acid with anti-amyloidogenic activity against Aβ in buffered solutions. However, there is still no evidence of these properties in vivo. Given the rate of failures of AD drug development, there is a huge demand of replicating the in vivo environment in in vitro studies, thus allowing to stop earlier the study of molecules with no effect in vivo. Thus, this study aims to evaluate the effect of in vitro neuronal membranes on the GA's ability in preventing Aβ1-42 aggregation and disrupting preformed fibrils. To this end, liposomes were employed to mimic the cell membrane environment. The results reveal that the lipid membranes did not affect the GA's ability in inhibiting Aβ1−42 fibrillation. However, in vitro neuronal membranes modulate the GA-induced Aβ fibrils disaggregation, which may be related with the moderate affinity of the compound for the lipid membrane. Even so, GA presented strong anti-amyloidogenic properties in the cell membrane-like environment. This work highlights the promising value of GA on preventing and treating AD, thus justifying its study in animal models." @default.
• W3196190746 created "2021-08-30" @default.
• W3196190746 creator A5003122342 @default.
• W3196190746 creator A5029455714 @default.
• W3196190746 creator A5069594191 @default.
• W3196190746 date "2021-08-01" @default.
• W3196190746 modified "2023-09-23" @default.
• W3196190746 title "Mitochondrial involvement in the development and progression of diseases" @default.
• W3196190746 cites W2520186370 @default.
• W3196190746 cites W2948231834 @default.
• W3196190746 cites W2989385987 @default.
• W3196190746 cites W3033337427 @default.
• W3196190746 cites W3094351301 @default.
• W3196190746 cites W3095909339 @default.
• W3196190746 cites W3096630375 @default.
• W3196190746 cites W3097687738 @default.
• W3196190746 cites W3099195164 @default.
• W3196190746 cites W3099300382 @default.
• W3196190746 cites W3108652804 @default.
• W3196190746 cites W3109431098 @default.
• W3196190746 cites W3112482793 @default.
• W3196190746 cites W3128141932 @default.
• W3196190746 cites W3133203934 @default.
• W3196190746 cites W3135660175 @default.
• W3196190746 cites W3140466607 @default.
• W3196190746 cites W3145733057 @default.
• W3196190746 cites W3155913697 @default.
• W3196190746 cites W3156256992 @default.
• W3196190746 cites W3162877118 @default.
• W3196190746 cites W3173605490 @default.
• W3196190746 doi "https://doi.org/10.1016/j.abb.2021.109006" @default.
• W3196190746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34400142" @default.
• W3196190746 hasPublicationYear "2021" @default.
• W3196190746 type Work @default.
• W3196190746 sameAs 3196190746 @default.
• W3196190746 citedByCount "0" @default.
• W3196190746 crossrefType "journal-article" @default.
• W3196190746 hasAuthorship W3196190746A5003122342 @default.
• W3196190746 hasAuthorship W3196190746A5029455714 @default.
• W3196190746 hasAuthorship W3196190746A5069594191 @default.
• W3196190746 hasConcept C12554922 @default.
• W3196190746 hasConcept C1491633281 @default.
• W3196190746 hasConcept C150903083 @default.
• W3196190746 hasConcept C164705383 @default.
• W3196190746 hasConcept C179104552 @default.
• W3196190746 hasConcept C185154212 @default.
• W3196190746 hasConcept C185592680 @default.
• W3196190746 hasConcept C202751555 @default.
• W3196190746 hasConcept C207001950 @default.
• W3196190746 hasConcept C27523624 @default.
• W3196190746 hasConcept C2777356233 @default.
• W3196190746 hasConcept C2777633098 @default.
• W3196190746 hasConcept C2778106830 @default.
• W3196190746 hasConcept C2779161974 @default.
• W3196190746 hasConcept C2779281246 @default.
• W3196190746 hasConcept C39944091 @default.
• W3196190746 hasConcept C41625074 @default.
• W3196190746 hasConcept C55493867 @default.
• W3196190746 hasConcept C71924100 @default.
• W3196190746 hasConcept C86803240 @default.
• W3196190746 hasConcept C95444343 @default.
• W3196190746 hasConceptScore W3196190746C12554922 @default.
• W3196190746 hasConceptScore W3196190746C1491633281 @default.
• W3196190746 hasConceptScore W3196190746C150903083 @default.
• W3196190746 hasConceptScore W3196190746C164705383 @default.
• W3196190746 hasConceptScore W3196190746C179104552 @default.
• W3196190746 hasConceptScore W3196190746C185154212 @default.
• W3196190746 hasConceptScore W3196190746C185592680 @default.
• W3196190746 hasConceptScore W3196190746C202751555 @default.
• W3196190746 hasConceptScore W3196190746C207001950 @default.
• W3196190746 hasConceptScore W3196190746C27523624 @default.
• W3196190746 hasConceptScore W3196190746C2777356233 @default.
• W3196190746 hasConceptScore W3196190746C2777633098 @default.
• W3196190746 hasConceptScore W3196190746C2778106830 @default.
• W3196190746 hasConceptScore W3196190746C2779161974 @default.
• W3196190746 hasConceptScore W3196190746C2779281246 @default.
• W3196190746 hasConceptScore W3196190746C39944091 @default.
• W3196190746 hasConceptScore W3196190746C41625074 @default.
• W3196190746 hasConceptScore W3196190746C55493867 @default.
• W3196190746 hasConceptScore W3196190746C71924100 @default.
• W3196190746 hasConceptScore W3196190746C86803240 @default.
• W3196190746 hasConceptScore W3196190746C95444343 @default.
• W3196190746 hasFunder F4320310013 @default.
• W3196190746 hasLocation W31961907461 @default.
• W3196190746 hasLocation W31961907462 @default.
• W3196190746 hasOpenAccess W3196190746 @default.
• W3196190746 hasPrimaryLocation W31961907461 @default.
• W3196190746 hasRelatedWork W1815329409 @default.
• W3196190746 hasRelatedWork W1986909470 @default.
• W3196190746 hasRelatedWork W2001923760 @default.
• W3196190746 hasRelatedWork W2027995645 @default.
• W3196190746 hasRelatedWork W2051109393 @default.
• W3196190746 hasRelatedWork W2183734092 @default.
• W3196190746 hasRelatedWork W2324640940 @default.
• W3196190746 hasRelatedWork W3181021834 @default.
• W3196190746 hasRelatedWork W3202309425 @default.
• W3196190746 hasRelatedWork W4327761939 @default.
• W3196190746 isParatext "false" @default.

• next