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• W3196203469 abstract "Developing a vaccine formula that alters the tumor-infiltrating lymphocytes to be more immune active against a tumor is key to the improvement of clinical responses to immunotherapy. Here, we demonstrate that, in conjunction with E7 antigen-specific immunotherapy, and IL-10 and PD-1 blockade, intratumoral administration of caerin 1.1/1.9 peptides improves TC-1 tumor microenvironment (TME) to be more immune active than injection of a control peptide.We compared the survival time of vaccinated TC-1 tumor-bearing mice with PD-1 and IL-10 blockade, in combination with a further injection of caerin 1.1/1.9 or control peptides. The tumor-infiltrating haematopoietic cells were examined by flow cytometry. Single-cell transcriptomics and proteomics were used to quantify changes in cellular activity across different cell types within the TME.The injection of caerin 1.1/1.9 increased the efficacy of vaccinated TC-1 tumor-bearing mice with anti-PD-1 treatment and largely expanded the populations of macrophages and NK cells with higher immune activation level, while reducing immunosuppressive macrophages. More activated CD8+ T cells were induced with higher populations of memory and effector-memory CD8+ T subsets. Computational integration of the proteome with the single-cell transcriptome supported activation of Stat1-modulated apoptosis and significant reduction in immune-suppressive B-cell function following caerin 1.1 and 1.9 treatment.Caerin 1.1/1.9-containing treatment results in improved antitumor responses. Harnessing the novel candidate genes preferentially enriched in the immune active cell populations may allow further exploration of distinct macrophages, T cells and their functions in TC-1 tumors." @default.
• W3196203469 created "2021-08-30" @default.
• W3196203469 creator A5011021850 @default.
• W3196203469 creator A5015055655 @default.
• W3196203469 creator A5017175637 @default.
• W3196203469 creator A5018866860 @default.
• W3196203469 creator A5048082417 @default.
• W3196203469 creator A5055905289 @default.
• W3196203469 creator A5060002817 @default.
• W3196203469 creator A5060330097 @default.
• W3196203469 creator A5066597852 @default.
• W3196203469 creator A5068935408 @default.
• W3196203469 creator A5072339448 @default.
• W3196203469 creator A5075945352 @default.
• W3196203469 date "2021-01-01" @default.
• W3196203469 modified "2023-10-18" @default.
• W3196203469 title "Intratumoral injection of caerin 1.1 and 1.9 peptides increases the efficacy of vaccinated TC‐1 tumor‐bearing mice with PD‐1 blockade by modulating macrophage heterogeneity and the activation of CD8⁺ T cells in the tumor microenvironment" @default.
• W3196203469 cites W1107917109 @default.
• W3196203469 cites W1498517665 @default.
• W3196203469 cites W1648893375 @default.
• W3196203469 cites W1952396307 @default.
• W3196203469 cites W1954263225 @default.
• W3196203469 cites W1969784891 @default.
• W3196203469 cites W1984786129 @default.
• W3196203469 cites W1989042049 @default.
• W3196203469 cites W1989277387 @default.
• W3196203469 cites W1993597798 @default.
• W3196203469 cites W1997677961 @default.
• W3196203469 cites W2005334224 @default.
• W3196203469 cites W2006236831 @default.
• W3196203469 cites W2016857233 @default.
• W3196203469 cites W2018644412 @default.
• W3196203469 cites W2022035454 @default.
• W3196203469 cites W2027470770 @default.
• W3196203469 cites W2037199116 @default.
• W3196203469 cites W2054661538 @default.
• W3196203469 cites W2072321567 @default.
• W3196203469 cites W2078403452 @default.
• W3196203469 cites W2080710417 @default.
• W3196203469 cites W2083970102 @default.
• W3196203469 cites W2084317828 @default.
• W3196203469 cites W2096173332 @default.
• W3196203469 cites W2096866753 @default.
• W3196203469 cites W2097769757 @default.
• W3196203469 cites W2102456086 @default.
• W3196203469 cites W2104711211 @default.
• W3196203469 cites W2107858772 @default.
• W3196203469 cites W2108767527 @default.
• W3196203469 cites W2113082145 @default.
• W3196203469 cites W2114970564 @default.
• W3196203469 cites W2125737991 @default.
• W3196203469 cites W2126997165 @default.
• W3196203469 cites W2127793792 @default.
• W3196203469 cites W2128241559 @default.
• W3196203469 cites W2131681506 @default.
• W3196203469 cites W2136148082 @default.
• W3196203469 cites W2136631125 @default.
• W3196203469 cites W2152517822 @default.
• W3196203469 cites W2157620455 @default.
• W3196203469 cites W2158976771 @default.
• W3196203469 cites W2159482845 @default.
• W3196203469 cites W2164451409 @default.
• W3196203469 cites W2165025975 @default.
• W3196203469 cites W2168251127 @default.
• W3196203469 cites W2179848746 @default.
• W3196203469 cites W2259858976 @default.
• W3196203469 cites W2344048868 @default.
• W3196203469 cites W2465158514 @default.
• W3196203469 cites W2520191991 @default.
• W3196203469 cites W2523856485 @default.
• W3196203469 cites W2555063238 @default.
• W3196203469 cites W2579058492 @default.
• W3196203469 cites W2582686270 @default.
• W3196203469 cites W2598058727 @default.
• W3196203469 cites W2605810679 @default.
• W3196203469 cites W2612166547 @default.
• W3196203469 cites W2615301036 @default.
• W3196203469 cites W2728365508 @default.
• W3196203469 cites W2735659715 @default.
• W3196203469 cites W2741321673 @default.
• W3196203469 cites W2766555128 @default.
• W3196203469 cites W2781615683 @default.
• W3196203469 cites W2788263670 @default.
• W3196203469 cites W2791483720 @default.
• W3196203469 cites W2791782504 @default.
• W3196203469 cites W2792855672 @default.
• W3196203469 cites W2795687816 @default.
• W3196203469 cites W2799402272 @default.
• W3196203469 cites W2802324542 @default.
• W3196203469 cites W2804441916 @default.
• W3196203469 cites W2804581735 @default.
• W3196203469 cites W2808039892 @default.
• W3196203469 cites W2808511349 @default.
• W3196203469 cites W2809355409 @default.
• W3196203469 cites W2829901800 @default.
• W3196203469 cites W2895456557 @default.
• W3196203469 cites W2898844941 @default.
• W3196203469 cites W2899760200 @default.
• W3196203469 cites W2902292985 @default.
• W3196203469 cites W2915756396 @default.

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