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- W3196216379 abstract "A 69-year-old male presented to dermatology with a 1-year history of an enlarging 3-cm ill-defined, indurated, sclerotic, and ulcerated mass on the nasal tip. Shave biopsy demonstrated squamous cell carcinoma (SCC) with atypical squamous cells exhibiting epithelioid and infiltrative patterns. Tissue from the Mohs debulk demonstrated a poorly differentiated carcinoma diffusely infiltrating the dermis with perineural invasion. Tumor cells were predominantly epithelioid cells with clear to eosinophilic cytoplasm forming cords, nests with occasional lumen, and focally diffuse sheets that exhibited positivity for CK5/6, CK7, p40, p63, EMA, Lu-5, D240, and CEA. Histologic and immunohistochemical features were consistent with squamoid eccrine ductal carcinoma (SEDC). The peripheral margin and majority of the deep margin were cleared with Mohs surgery. Due to invasion into the nasal septum, further excision and repair was done by ENT Facial Plastics. Clear margins were obtained. CT imaging was negative for intracranial metastasis, neck masses, or regional lymphadenopathy. SEDC is a rare subtype of eccrine carcinoma with approximately 60 reported cases since initial description in 1997. Lesions appear as ulcerated nodules or plaques on sun exposed skin. Histologic features include superficial atypical squamous proliferation with deeper eccrine ductal differentiation and immunohistologic positivity indicative of eccrine origin. Lack of characteristic ductal features in the superficial portion of the tumor has led to initial misdiagnosis as SCC in shallow biopsies. SEDC has a 13% rate of metastasis with 1 reported death and multiple reports of local recurrence after wide excision. Outstanding clinical and histologic images will be presented." @default.
- W3196216379 created "2021-08-30" @default.
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- W3196216379 date "2021-09-01" @default.
- W3196216379 modified "2023-09-26" @default.
- W3196216379 title "26453 Squamoid eccrine ductal carcinoma of the nose requiring extensive resection and reconstruction" @default.
- W3196216379 doi "https://doi.org/10.1016/j.jaad.2021.06.424" @default.
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