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• W3196267934 endingPage "753" @default.
• W3196267934 startingPage "737" @default.
• W3196267934 abstract "Experimental cerebral malaria (ECM) is a severe complication of Plasmodium berghei ANKA (PbA) infection in mice, characterized by CD8+ T-cell accumulation within the brain. Whilst the dynamics of CD8+ T-cell activation and migration during extant primary PbA infection have been extensively researched, the fate of the parasite-specific CD8+ T cells upon resolution of ECM is not understood. In this study, we show that memory OT-I cells persist systemically within the spleen, lung and brain following recovery from ECM after primary PbA-OVA infection. Whereas memory OT-I cells within the spleen and lung exhibited canonical central memory (Tcm) and effector memory (Tem) phenotypes, respectively, memory OT-I cells within the brain post-PbA-OVA infection displayed an enriched CD69+ CD103- profile and expressed low levels of T-bet. OT-I cells within the brain were excluded from short-term intravascular antibody labelling but were targeted effectively by longer-term systemically administered antibodies. Thus, the memory OT-I cells were extravascular within the brain post-ECM but were potentially not resident memory cells. Importantly, whilst memory OT-I cells exhibited strong reactivation during secondary PbA-OVA infection, preventing activation of new primary effector T cells, they had dampened reactivation during a fourth PbA-OVA infection. Overall, our results demonstrate that memory CD8+ T cells are systemically distributed but exhibit a unique phenotype within the brain post-ECM, and that their reactivation characteristics are shaped by infection history. Our results raise important questions regarding the role of distinct memory CD8+ T-cell populations within the brain and other tissues during repeat Plasmodium infections." @default.
• W3196267934 created "2021-08-30" @default.
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• W3196267934 date "2021-08-27" @default.
• W3196267934 modified "2023-10-18" @default.
• W3196267934 title "Memory CD8⁺ T cells exhibit tissue imprinting and non‐stable exposure‐dependent reactivation characteristics following blood‐stage <i>Plasmodium berghei</i> ANKA infections" @default.
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• W3196267934 doi "https://doi.org/10.1111/imm.13405" @default.
• W3196267934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8561116" @default.
• W3196267934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34407221" @default.
• W3196267934 hasPublicationYear "2021" @default.
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