FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196281882> ?p ?o ?g. }

• W3196281882 abstract "Abstract Group A Streptococcus (GAS, Streptococcus pyogenes ) is a professional human pathogen that commonly infects the skin. Keratinocytes are one of the first cells to contact GAS, and by inducing inflammation, they can initiate the earliest immune responses to pathogen invasion. Here, we characterized the proinflammatory cytokine repertoire produced by primary human keratinocytes and surrogate cell lines commonly used in vitro . Infection induces several cytokines and chemokines, but keratinocytes constitutively secrete IL-18 in a form that is inert (pro-IL-18) and lacks proinflammatory activity. Canonically, IL-18 activation and secretion are coupled through a single proteolytic event that is regulated intracellularly by the inflammasome protease caspase-1 in myeloid cells. The pool of extracellular pro-IL-18 generated by keratinocytes is poised to sense extracellular proteases and is directly processed into a mature active form by SpeB, a secreted GAS protease that is a critical virulent factor during skin infection. This mechanism contributes to the proinflammatory response against GAS, resulting in T cell activation and the secretion of IFN-γ that restrict GAS growth. Other major bacterial pathogens and microbiota of this skin did not have significant IL-18-maturing ability. Taken together, these results suggest keratinocyte-secreted IL-18 is a sentinel that sounds an early alarm that is highly sensitive to GAS, yet tolerant to non-invasive members of the microbiota." @default.
• W3196281882 created "2021-08-30" @default.
• W3196281882 creator A5006160502 @default.
• W3196281882 creator A5024568231 @default.
• W3196281882 creator A5027499625 @default.
• W3196281882 creator A5070546409 @default.
• W3196281882 creator A5084501937 @default.
• W3196281882 creator A5087564735 @default.
• W3196281882 date "2021-08-22" @default.
• W3196281882 modified "2023-10-10" @default.
• W3196281882 title "Pro-IL-18 secreted by keratinocytes detects the group A streptococcal protease SpeB" @default.
• W3196281882 cites W1586421775 @default.
• W3196281882 cites W1896675849 @default.
• W3196281882 cites W1987894090 @default.
• W3196281882 cites W1989272448 @default.
• W3196281882 cites W1996729081 @default.
• W3196281882 cites W2002892988 @default.
• W3196281882 cites W2012365327 @default.
• W3196281882 cites W2014094896 @default.
• W3196281882 cites W2029696790 @default.
• W3196281882 cites W2045922872 @default.
• W3196281882 cites W2048086790 @default.
• W3196281882 cites W2052895824 @default.
• W3196281882 cites W2059589821 @default.
• W3196281882 cites W2065184397 @default.
• W3196281882 cites W2089638136 @default.
• W3196281882 cites W2102037321 @default.
• W3196281882 cites W2102943702 @default.
• W3196281882 cites W2110318063 @default.
• W3196281882 cites W2111307900 @default.
• W3196281882 cites W2117139129 @default.
• W3196281882 cites W2123476794 @default.
• W3196281882 cites W2123531771 @default.
• W3196281882 cites W2124251160 @default.
• W3196281882 cites W2127314810 @default.
• W3196281882 cites W2127352753 @default.
• W3196281882 cites W2130490281 @default.
• W3196281882 cites W2130940574 @default.
• W3196281882 cites W2131543814 @default.
• W3196281882 cites W2131912308 @default.
• W3196281882 cites W2135690913 @default.
• W3196281882 cites W2137211177 @default.
• W3196281882 cites W2152838079 @default.
• W3196281882 cites W2161305783 @default.
• W3196281882 cites W2165239282 @default.
• W3196281882 cites W2171831396 @default.
• W3196281882 cites W2175735715 @default.
• W3196281882 cites W2509769677 @default.
• W3196281882 cites W2687206218 @default.
• W3196281882 cites W2801103680 @default.
• W3196281882 cites W2807099918 @default.
• W3196281882 cites W2810461543 @default.
• W3196281882 cites W2960317292 @default.
• W3196281882 cites W2990559739 @default.
• W3196281882 cites W3010988898 @default.
• W3196281882 cites W3037257919 @default.
• W3196281882 cites W3049434679 @default.
• W3196281882 cites W3178652021 @default.
• W3196281882 doi "https://doi.org/10.1101/2021.08.22.457234" @default.
• W3196281882 hasPublicationYear "2021" @default.
• W3196281882 type Work @default.
• W3196281882 sameAs 3196281882 @default.
• W3196281882 citedByCount "1" @default.
• W3196281882 countsByYear W31962818822023 @default.
• W3196281882 crossrefType "posted-content" @default.
• W3196281882 hasAuthorship W3196281882A5006160502 @default.
• W3196281882 hasAuthorship W3196281882A5024568231 @default.
• W3196281882 hasAuthorship W3196281882A5027499625 @default.
• W3196281882 hasAuthorship W3196281882A5070546409 @default.
• W3196281882 hasAuthorship W3196281882A5084501937 @default.
• W3196281882 hasAuthorship W3196281882A5087564735 @default.
• W3196281882 hasBestOaLocation W31962818821 @default.
• W3196281882 hasConcept C13373296 @default.
• W3196281882 hasConcept C164027704 @default.
• W3196281882 hasConcept C181199279 @default.
• W3196281882 hasConcept C182220744 @default.
• W3196281882 hasConcept C203014093 @default.
• W3196281882 hasConcept C2776914184 @default.
• W3196281882 hasConcept C2777209026 @default.
• W3196281882 hasConcept C2779306812 @default.
• W3196281882 hasConcept C2779489039 @default.
• W3196281882 hasConcept C49039625 @default.
• W3196281882 hasConcept C523546767 @default.
• W3196281882 hasConcept C54355233 @default.
• W3196281882 hasConcept C55493867 @default.
• W3196281882 hasConcept C86803240 @default.
• W3196281882 hasConcept C8891405 @default.
• W3196281882 hasConcept C89423630 @default.
• W3196281882 hasConcept C95444343 @default.
• W3196281882 hasConceptScore W3196281882C13373296 @default.
• W3196281882 hasConceptScore W3196281882C164027704 @default.
• W3196281882 hasConceptScore W3196281882C181199279 @default.
• W3196281882 hasConceptScore W3196281882C182220744 @default.
• W3196281882 hasConceptScore W3196281882C203014093 @default.
• W3196281882 hasConceptScore W3196281882C2776914184 @default.
• W3196281882 hasConceptScore W3196281882C2777209026 @default.
• W3196281882 hasConceptScore W3196281882C2779306812 @default.
• W3196281882 hasConceptScore W3196281882C2779489039 @default.
• W3196281882 hasConceptScore W3196281882C49039625 @default.
• W3196281882 hasConceptScore W3196281882C523546767 @default.

• next