FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196338923> ?p ?o ?g. }

• W3196338923 endingPage "S383" @default.
• W3196338923 startingPage "S383" @default.
• W3196338923 abstract "The majority of relapsed or refractory lymphoma patients undergo salvage chemotherapy and autologous stem cell transplant (ASCT). Data on venous thromboembolic events (VTEs) in this setting are scarce. This study aims to evaluate the incidence, pattern, and risk factors for VTEs in this group of patients across the continuum of their care. The medical records of adult patients, aged ≥ 18 years, who were diagnosed and treated at our institution from 2007 to 2017 with refractory or relapsed lymphoma and received salvage therapy followed by high-dose chemotherapy and autologous stem cell transplant were retrospectively reviewed. A total of 216 patients, with a median age of 31 (range: 19–60) years, were identified. In total, 36 (16.7%) patients had VTE, mostly in the upper extremity (n=28, 77.8%); 50.0% were related to central venous catheter. Thrombosis rates were higher among patients with high lactate dehydrogenase (LDH) (29.2% vs 5.9%, p< 0.001), mediastinal involvement (25.9% vs 11.5%, p=0.025) and in patients with longer hospital stay (22.1% vs 9.5%, p=0.036). In multivariate analysis, high LDH (OR: 7.66; 95% CI: 2.79–21.04, p<0.001) and mediastinal involvement (OR, 3.64; 95% CI: 1.53–8.70, p=0.002) were associated with significantly higher rates of VTE. In conclusion, patients with relapsed lymphoma undergoing ASCT are at higher risk for VTE, especially those with high LDH and mediastinal involvement. Thromboprophylaxis might be considered in these settings. The majority of relapsed or refractory lymphoma patients undergo salvage chemotherapy and autologous stem cell transplant (ASCT). Data on venous thromboembolic events (VTEs) in this setting are scarce. This study aims to evaluate the incidence, pattern, and risk factors for VTEs in this group of patients across the continuum of their care. The medical records of adult patients, aged ≥ 18 years, who were diagnosed and treated at our institution from 2007 to 2017 with refractory or relapsed lymphoma and received salvage therapy followed by high-dose chemotherapy and autologous stem cell transplant were retrospectively reviewed. A total of 216 patients, with a median age of 31 (range: 19–60) years, were identified. In total, 36 (16.7%) patients had VTE, mostly in the upper extremity (n=28, 77.8%); 50.0% were related to central venous catheter. Thrombosis rates were higher among patients with high lactate dehydrogenase (LDH) (29.2% vs 5.9%, p< 0.001), mediastinal involvement (25.9% vs 11.5%, p=0.025) and in patients with longer hospital stay (22.1% vs 9.5%, p=0.036). In multivariate analysis, high LDH (OR: 7.66; 95% CI: 2.79–21.04, p<0.001) and mediastinal involvement (OR, 3.64; 95% CI: 1.53–8.70, p=0.002) were associated with significantly higher rates of VTE. In conclusion, patients with relapsed lymphoma undergoing ASCT are at higher risk for VTE, especially those with high LDH and mediastinal involvement. Thromboprophylaxis might be considered in these settings." @default.
• W3196338923 created "2021-09-13" @default.
• W3196338923 creator A5010761942 @default.
• W3196338923 creator A5017617655 @default.
• W3196338923 creator A5025293277 @default.
• W3196338923 creator A5032290025 @default.
• W3196338923 creator A5036173337 @default.
• W3196338923 creator A5038009535 @default.
• W3196338923 creator A5054843211 @default.
• W3196338923 creator A5070338918 @default.
• W3196338923 creator A5082050917 @default.
• W3196338923 creator A5082131819 @default.
• W3196338923 date "2021-09-01" @default.
• W3196338923 modified "2023-09-27" @default.
• W3196338923 title "ABCL-230: Prevalence, Patterns, and Predictors of Venous Thromboembolic Events in Patients Undergoing Salvage Chemotherapy and Autologous Stem Cell Transplant for Relapsed Lymphomas" @default.
• W3196338923 doi "https://doi.org/10.1016/s2152-2650(21)01872-3" @default.
• W3196338923 hasPublicationYear "2021" @default.
• W3196338923 type Work @default.
• W3196338923 sameAs 3196338923 @default.
• W3196338923 citedByCount "0" @default.
• W3196338923 crossrefType "journal-article" @default.
• W3196338923 hasAuthorship W3196338923A5010761942 @default.
• W3196338923 hasAuthorship W3196338923A5017617655 @default.
• W3196338923 hasAuthorship W3196338923A5025293277 @default.
• W3196338923 hasAuthorship W3196338923A5032290025 @default.
• W3196338923 hasAuthorship W3196338923A5036173337 @default.
• W3196338923 hasAuthorship W3196338923A5038009535 @default.
• W3196338923 hasAuthorship W3196338923A5054843211 @default.
• W3196338923 hasAuthorship W3196338923A5070338918 @default.
• W3196338923 hasAuthorship W3196338923A5082050917 @default.
• W3196338923 hasAuthorship W3196338923A5082131819 @default.
• W3196338923 hasConcept C120665830 @default.
• W3196338923 hasConcept C121332964 @default.
• W3196338923 hasConcept C126322002 @default.
• W3196338923 hasConcept C141071460 @default.
• W3196338923 hasConcept C142424586 @default.
• W3196338923 hasConcept C2776694085 @default.
• W3196338923 hasConcept C2779050716 @default.
• W3196338923 hasConcept C2779338263 @default.
• W3196338923 hasConcept C2780775027 @default.
• W3196338923 hasConcept C61511704 @default.
• W3196338923 hasConcept C71924100 @default.
• W3196338923 hasConcept C87355193 @default.
• W3196338923 hasConcept C90924648 @default.
• W3196338923 hasConceptScore W3196338923C120665830 @default.
• W3196338923 hasConceptScore W3196338923C121332964 @default.
• W3196338923 hasConceptScore W3196338923C126322002 @default.
• W3196338923 hasConceptScore W3196338923C141071460 @default.
• W3196338923 hasConceptScore W3196338923C142424586 @default.
• W3196338923 hasConceptScore W3196338923C2776694085 @default.
• W3196338923 hasConceptScore W3196338923C2779050716 @default.
• W3196338923 hasConceptScore W3196338923C2779338263 @default.
• W3196338923 hasConceptScore W3196338923C2780775027 @default.
• W3196338923 hasConceptScore W3196338923C61511704 @default.
• W3196338923 hasConceptScore W3196338923C71924100 @default.
• W3196338923 hasConceptScore W3196338923C87355193 @default.
• W3196338923 hasConceptScore W3196338923C90924648 @default.
• W3196338923 hasLocation W31963389231 @default.
• W3196338923 hasOpenAccess W3196338923 @default.
• W3196338923 hasPrimaryLocation W31963389231 @default.
• W3196338923 hasRelatedWork W2040492280 @default.
• W3196338923 hasRelatedWork W2045177263 @default.
• W3196338923 hasRelatedWork W2105293222 @default.
• W3196338923 hasRelatedWork W2123990658 @default.
• W3196338923 hasRelatedWork W2415576058 @default.
• W3196338923 hasRelatedWork W2464045689 @default.
• W3196338923 hasRelatedWork W2467023771 @default.
• W3196338923 hasRelatedWork W2528057197 @default.
• W3196338923 hasRelatedWork W4224443308 @default.
• W3196338923 hasRelatedWork W4238484593 @default.
• W3196338923 hasVolume "21" @default.
• W3196338923 isParatext "false" @default.
• W3196338923 isRetracted "false" @default.
• W3196338923 magId "3196338923" @default.
• W3196338923 workType "article" @default.