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- W3196344049 endingPage "598" @default.
- W3196344049 startingPage "575" @default.
- W3196344049 abstract "Drug addiction is characterized by abnormal and often persistent changes in gene expression throughout the limbic circuitry of the brain. Over the past decade, epigenetic mechanisms, such as alterations in histone posttranslational modifications and DNA methylation, have been suggested to play key roles in the orchestration of dynamic and long-lasting transcriptional and behavioral responses to drugs of abuse. Numerous environmental factors that are known to enhance an individual’s vulnerability to drug addiction have similarly been demonstrated to promote persistent changes in neuronal chromatin function in the brain. Here, we will attempt to shed light on the epigenetic mechanisms contributing to addiction vulnerability, with the hope that current and future studies will aid in the development of improved strategies for the prevention and treatment of this devastating psychiatric disease." @default.
- W3196344049 created "2021-09-13" @default.
- W3196344049 creator A5043351052 @default.
- W3196344049 creator A5060638192 @default.
- W3196344049 creator A5077393289 @default.
- W3196344049 date "2021-01-01" @default.
- W3196344049 modified "2023-09-26" @default.
- W3196344049 title "Epigenetic mechanisms of drug addiction vulnerability" @default.
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