FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196344896> ?p ?o ?g. }

• W3196344896 abstract "Whilst the ability of AMH to induce the regression of the Müllerian ducts in the male fetus is well appreciated, AMH has additional biological actions in relation to steroid biosynthesis and ovarian follicle dynamics. An understanding of the physiology of AMH illuminates the potential therapeutic utility of AMH to protect the ovarian reserve during chemotherapy and in the treatment of female malignancies. The translation of the biological actions of AMH into clinical applications is an emerging focus of research, with promising preliminary results.Studies indicate AMH restrains primordial follicle development, thus administration of AMH during chemotherapy may protect the ovarian reserve by preventing the mass activation of primordial follicles. As AMH induces regression of tissues expressing the AMH receptor (AMHRII), administration of AMH may inhibit growth of malignancies expressing AMHR II. This review evaluates the biological actions of AMH in females and appraises human clinical applications.A comprehensive search of the Medline and EMBASE databases seeking articles related to the physiological functions and therapeutic applications of AMH was conducted in July 2021. The search was limited to studies published in English.AMH regulates primordial follicle recruitment and moderates sex steroid production through the inhibition of transcription of enzymes in the steroid biosynthetic pathway, primarily aromatase and 17α-hydroxylase/17,20-lyase. Preliminary data indicates that administration of AMH to mice during chemotherapy conveys a degree of protection to the ovarian reserve. Administration of AMH at the time of ovarian tissue grafting has the potential to restrain uncontrolled primordial follicle growth during revascularization. Numerous studies demonstrate AMH induced regression of AMHR II expressing malignancies. As this action occurs via a different mechanism to traditional chemotherapeutic agents, AMH has the capacity to inhibit proliferation of chemo-resistant ovarian cancer cells and cancer stem cells.To date, AMH has not been administered to humans. Data identified in this review suggests administration of AMH would be safe and well tolerated. Administration of AMH during chemotherapy may provide a synchronistic benefit to women with an AMHR II expressing malignancy, protecting the ovarian reserve whilst the cancer is treated by dual mechanisms." @default.
• W3196344896 created "2021-09-13" @default.
• W3196344896 creator A5002945739 @default.
• W3196344896 creator A5025820202 @default.
• W3196344896 creator A5072724499 @default.
• W3196344896 creator A5076561635 @default.
• W3196344896 date "2021-09-07" @default.
• W3196344896 modified "2023-09-25" @default.
• W3196344896 title "Translational Physiology of Anti-Müllerian Hormone: Clinical Applications in Female Fertility Preservation and Cancer Treatment" @default.
• W3196344896 cites W1419053213 @default.
• W3196344896 cites W1514830813 @default.
• W3196344896 cites W1559033760 @default.
• W3196344896 cites W1577197107 @default.
• W3196344896 cites W1639311959 @default.
• W3196344896 cites W1947926525 @default.
• W3196344896 cites W1963625504 @default.
• W3196344896 cites W1970770759 @default.
• W3196344896 cites W1971018649 @default.
• W3196344896 cites W1974756790 @default.
• W3196344896 cites W1975527793 @default.
• W3196344896 cites W1978068798 @default.
• W3196344896 cites W1990438615 @default.
• W3196344896 cites W1991459521 @default.
• W3196344896 cites W1993692364 @default.
• W3196344896 cites W1994242033 @default.
• W3196344896 cites W1995664887 @default.
• W3196344896 cites W1996485730 @default.
• W3196344896 cites W1996621706 @default.
• W3196344896 cites W1998445103 @default.
• W3196344896 cites W2000270540 @default.
• W3196344896 cites W2000569979 @default.
• W3196344896 cites W2001900604 @default.
• W3196344896 cites W2002013266 @default.
• W3196344896 cites W2002799589 @default.
• W3196344896 cites W2006826132 @default.
• W3196344896 cites W2006927392 @default.
• W3196344896 cites W2008048871 @default.
• W3196344896 cites W2009207386 @default.
• W3196344896 cites W2010778033 @default.
• W3196344896 cites W2012975737 @default.
• W3196344896 cites W2013296005 @default.
• W3196344896 cites W2018166691 @default.
• W3196344896 cites W2019081179 @default.
• W3196344896 cites W2026733011 @default.
• W3196344896 cites W2029490482 @default.
• W3196344896 cites W2030821262 @default.
• W3196344896 cites W2031271949 @default.
• W3196344896 cites W2037264541 @default.
• W3196344896 cites W2037395479 @default.
• W3196344896 cites W2037764323 @default.
• W3196344896 cites W2039537273 @default.
• W3196344896 cites W2051816002 @default.
• W3196344896 cites W2054047671 @default.
• W3196344896 cites W2054389360 @default.
• W3196344896 cites W2055848790 @default.
• W3196344896 cites W2056753028 @default.
• W3196344896 cites W2058965368 @default.
• W3196344896 cites W2059143304 @default.
• W3196344896 cites W2059969773 @default.
• W3196344896 cites W2062368870 @default.
• W3196344896 cites W2072646838 @default.
• W3196344896 cites W2074892757 @default.
• W3196344896 cites W2083002323 @default.
• W3196344896 cites W2084756409 @default.
• W3196344896 cites W2086484290 @default.
• W3196344896 cites W2087099484 @default.
• W3196344896 cites W2087703318 @default.
• W3196344896 cites W2088997680 @default.
• W3196344896 cites W2089195600 @default.
• W3196344896 cites W2089710998 @default.
• W3196344896 cites W2095817945 @default.
• W3196344896 cites W2097540678 @default.
• W3196344896 cites W2101302025 @default.
• W3196344896 cites W2101897761 @default.
• W3196344896 cites W2102109395 @default.
• W3196344896 cites W2103575684 @default.
• W3196344896 cites W2105482459 @default.
• W3196344896 cites W2109166024 @default.
• W3196344896 cites W2117163620 @default.
• W3196344896 cites W2120842955 @default.
• W3196344896 cites W2124400692 @default.
• W3196344896 cites W2131854962 @default.
• W3196344896 cites W2132660815 @default.
• W3196344896 cites W2134989837 @default.
• W3196344896 cites W2136159364 @default.
• W3196344896 cites W2139777504 @default.
• W3196344896 cites W2142385140 @default.
• W3196344896 cites W2144005229 @default.
• W3196344896 cites W2144641360 @default.
• W3196344896 cites W2146483619 @default.
• W3196344896 cites W2147546864 @default.
• W3196344896 cites W2148070806 @default.
• W3196344896 cites W2151044217 @default.
• W3196344896 cites W2151333869 @default.
• W3196344896 cites W2157544609 @default.
• W3196344896 cites W2160864692 @default.
• W3196344896 cites W2167893699 @default.
• W3196344896 cites W2168226448 @default.
• W3196344896 cites W2170395027 @default.
• W3196344896 cites W2191076225 @default.

• next