FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196353619> ?p ?o ?g. }

• W3196353619 abstract "The transcription factor NFATC2 induces β cell proliferation in mouse and human islets. However, the genomic targets that mediate these effects have not been identified. We expressed active forms of Nfatc2 and Nfatc1 in human islets. By integrating changes in gene expression with genomic binding sites for NFATC2, we identified approximately 2200 transcriptional targets of NFATC2. Genes induced by NFATC2 were enriched for transcripts that regulate the cell cycle and for DNA motifs associated with the transcription factor FOXP. Islets from an endocrine-specific Foxp1, Foxp2, and Foxp4 triple-knockout mouse were less responsive to NFATC2-induced β cell proliferation, suggesting the FOXP family works to regulate β cell proliferation in concert with NFATC2. NFATC2 induced β cell proliferation in both mouse and human islets, whereas NFATC1 did so only in human islets. Exploiting this species difference, we identified approximately 250 direct transcriptional targets of NFAT in human islets. This gene set enriches for cell cycle–associated transcripts and includes Nr4a1. Deletion of Nr4a1 reduced the capacity of NFATC2 to induce β cell proliferation, suggesting that much of the effect of NFATC2 occurs through its induction of Nr4a1. Integration of noncoding RNA expression, chromatin accessibility, and NFATC2 binding sites enabled us to identify NFATC2-dependent enhancer loci that mediate β cell proliferation." @default.
• W3196353619 created "2021-09-13" @default.
• W3196353619 creator A5000617179 @default.
• W3196353619 creator A5003503515 @default.
• W3196353619 creator A5011334678 @default.
• W3196353619 creator A5011341759 @default.
• W3196353619 creator A5013112733 @default.
• W3196353619 creator A5015592813 @default.
• W3196353619 creator A5016092157 @default.
• W3196353619 creator A5020392267 @default.
• W3196353619 creator A5020897631 @default.
• W3196353619 creator A5022565171 @default.
• W3196353619 creator A5023893268 @default.
• W3196353619 creator A5027290261 @default.
• W3196353619 creator A5029187572 @default.
• W3196353619 creator A5053584183 @default.
• W3196353619 creator A5057167550 @default.
• W3196353619 creator A5058786366 @default.
• W3196353619 creator A5061408240 @default.
• W3196353619 creator A5066344931 @default.
• W3196353619 creator A5079693358 @default.
• W3196353619 creator A5086207166 @default.
• W3196353619 creator A5089794744 @default.
• W3196353619 date "2021-11-01" @default.
• W3196353619 modified "2023-10-16" @default.
• W3196353619 title "Identification of direct transcriptional targets of NFATC2 that promote β cell proliferation" @default.
• W3196353619 cites W1847275787 @default.
• W3196353619 cites W1904129523 @default.
• W3196353619 cites W1938602274 @default.
• W3196353619 cites W1960734071 @default.
• W3196353619 cites W1969012014 @default.
• W3196353619 cites W1970772098 @default.
• W3196353619 cites W1971116120 @default.
• W3196353619 cites W1979354965 @default.
• W3196353619 cites W1981030303 @default.
• W3196353619 cites W1986586739 @default.
• W3196353619 cites W1991466774 @default.
• W3196353619 cites W1993414127 @default.
• W3196353619 cites W1995518565 @default.
• W3196353619 cites W1996470896 @default.
• W3196353619 cites W1997590968 @default.
• W3196353619 cites W2000672459 @default.
• W3196353619 cites W2003454094 @default.
• W3196353619 cites W2004466285 @default.
• W3196353619 cites W2012332098 @default.
• W3196353619 cites W2015845481 @default.
• W3196353619 cites W2018628319 @default.
• W3196353619 cites W2020627718 @default.
• W3196353619 cites W2036145275 @default.
• W3196353619 cites W2038784204 @default.
• W3196353619 cites W2045273474 @default.
• W3196353619 cites W2048637392 @default.
• W3196353619 cites W2065426985 @default.
• W3196353619 cites W2074656730 @default.
• W3196353619 cites W2075232662 @default.
• W3196353619 cites W2079407198 @default.
• W3196353619 cites W2082793267 @default.
• W3196353619 cites W2084076332 @default.
• W3196353619 cites W2095365870 @default.
• W3196353619 cites W2098023402 @default.
• W3196353619 cites W2100779682 @default.
• W3196353619 cites W2103017472 @default.
• W3196353619 cites W2110256992 @default.
• W3196353619 cites W2111886083 @default.
• W3196353619 cites W2114866946 @default.
• W3196353619 cites W2116015828 @default.
• W3196353619 cites W2117692196 @default.
• W3196353619 cites W2140707292 @default.
• W3196353619 cites W2147095419 @default.
• W3196353619 cites W2147243605 @default.
• W3196353619 cites W2155744133 @default.
• W3196353619 cites W2157973267 @default.
• W3196353619 cites W2163616479 @default.
• W3196353619 cites W2177538943 @default.
• W3196353619 cites W2192926654 @default.
• W3196353619 cites W2234989637 @default.
• W3196353619 cites W2239799525 @default.
• W3196353619 cites W2258420810 @default.
• W3196353619 cites W2311512974 @default.
• W3196353619 cites W2322477027 @default.
• W3196353619 cites W2338118586 @default.
• W3196353619 cites W2363193728 @default.
• W3196353619 cites W2437913713 @default.
• W3196353619 cites W2461793432 @default.
• W3196353619 cites W2518918481 @default.
• W3196353619 cites W2533095644 @default.
• W3196353619 cites W2548678995 @default.
• W3196353619 cites W2560449517 @default.
• W3196353619 cites W2581307619 @default.
• W3196353619 cites W2592944953 @default.
• W3196353619 cites W2611545198 @default.
• W3196353619 cites W2613482929 @default.
• W3196353619 cites W2755172706 @default.
• W3196353619 cites W2756185904 @default.
• W3196353619 cites W2777574440 @default.
• W3196353619 cites W2789609639 @default.
• W3196353619 cites W2790048311 @default.
• W3196353619 cites W2792469977 @default.
• W3196353619 cites W2893404020 @default.
• W3196353619 cites W2894662039 @default.

• next