Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196377908> ?p ?o ?g. }
- W3196377908 endingPage "e0257012" @default.
- W3196377908 startingPage "e0257012" @default.
- W3196377908 abstract "Sodium carboxymethyl starch (CMS-Na), a kind of food additive with high degree of substitution, is also known as a prebiotic. The aim of this study was to determine the effect of CMS-Na on defecation. Constipated mouse model was prepared by loperamide. Normal rats were also used in the study. Short-chain fatty acids in rat feces were detected by gas chromatography. The bacterial communities in rat feces were identified by 16S rDNA gene sequencing. 5-hydroxytryptamine (5-HT) and tryptophan hydroxylase 1 (Tph1) were measured by ELISA. The results showed that CMS-Na increased the fecal granule counts and intestinal propulsion rate in constipated mice. The contents of water, acetic acid, propionic acid and n-butyrate in feces, Tph1 in colon and 5-HT in serum of rats were increased. In addition, CMS-Na shortened the colonic transport time in rats. The 16S rDNA gene sequencing results indicated that CMS-Na increased the relative abundance of Alloprevotella and decreased the proportion of Lactobacillus. However, the biodiversity of the normal intestinal flora was not altered. In conclusion, CMS-Na can promote defecation in constipated mice. The mechanism may be related to the regulation of Alloprevotella and Lactobacillus in colon, the increase of short-chain fatty acids, and the promotion of the synthesis of Tph1 and 5-HT." @default.
- W3196377908 created "2021-09-13" @default.
- W3196377908 creator A5009017779 @default.
- W3196377908 creator A5017869659 @default.
- W3196377908 creator A5018122772 @default.
- W3196377908 creator A5075666941 @default.
- W3196377908 creator A5078462427 @default.
- W3196377908 creator A5083088136 @default.
- W3196377908 date "2021-09-03" @default.
- W3196377908 modified "2023-10-18" @default.
- W3196377908 title "The effect of sodium carboxymethyl starch with high degree of substitution on defecation" @default.
- W3196377908 cites W1597626394 @default.
- W3196377908 cites W1778260808 @default.
- W3196377908 cites W1793035576 @default.
- W3196377908 cites W1844869966 @default.
- W3196377908 cites W1881689363 @default.
- W3196377908 cites W1893993890 @default.
- W3196377908 cites W1934835051 @default.
- W3196377908 cites W1943555183 @default.
- W3196377908 cites W1997608252 @default.
- W3196377908 cites W2003617385 @default.
- W3196377908 cites W2025956148 @default.
- W3196377908 cites W2027490473 @default.
- W3196377908 cites W2032409964 @default.
- W3196377908 cites W2035663126 @default.
- W3196377908 cites W2043220334 @default.
- W3196377908 cites W2068264586 @default.
- W3196377908 cites W2071156644 @default.
- W3196377908 cites W2072970694 @default.
- W3196377908 cites W2096219534 @default.
- W3196377908 cites W2099465014 @default.
- W3196377908 cites W2102436949 @default.
- W3196377908 cites W2106017790 @default.
- W3196377908 cites W2112697086 @default.
- W3196377908 cites W2114295370 @default.
- W3196377908 cites W2119784436 @default.
- W3196377908 cites W2127029801 @default.
- W3196377908 cites W2131271579 @default.
- W3196377908 cites W2139365340 @default.
- W3196377908 cites W2140958896 @default.
- W3196377908 cites W2155948158 @default.
- W3196377908 cites W2161996137 @default.
- W3196377908 cites W2164055731 @default.
- W3196377908 cites W2344284541 @default.
- W3196377908 cites W2482094715 @default.
- W3196377908 cites W2508203511 @default.
- W3196377908 cites W2543000715 @default.
- W3196377908 cites W2575984858 @default.
- W3196377908 cites W2600368530 @default.
- W3196377908 cites W2602278063 @default.
- W3196377908 cites W2615801135 @default.
- W3196377908 cites W2765260213 @default.
- W3196377908 cites W2772176268 @default.
- W3196377908 cites W2791035781 @default.
- W3196377908 cites W2896002827 @default.
- W3196377908 cites W2897482670 @default.
- W3196377908 cites W4230474098 @default.
- W3196377908 doi "https://doi.org/10.1371/journal.pone.0257012" @default.
- W3196377908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8415588" @default.
- W3196377908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34478474" @default.
- W3196377908 hasPublicationYear "2021" @default.
- W3196377908 type Work @default.
- W3196377908 sameAs 3196377908 @default.
- W3196377908 citedByCount "1" @default.
- W3196377908 countsByYear W31963779082022 @default.
- W3196377908 crossrefType "journal-article" @default.
- W3196377908 hasAuthorship W3196377908A5009017779 @default.
- W3196377908 hasAuthorship W3196377908A5017869659 @default.
- W3196377908 hasAuthorship W3196377908A5018122772 @default.
- W3196377908 hasAuthorship W3196377908A5075666941 @default.
- W3196377908 hasAuthorship W3196377908A5078462427 @default.
- W3196377908 hasAuthorship W3196377908A5083088136 @default.
- W3196377908 hasBestOaLocation W31963779081 @default.
- W3196377908 hasConcept C100544194 @default.
- W3196377908 hasConcept C108797546 @default.
- W3196377908 hasConcept C126322002 @default.
- W3196377908 hasConcept C178790620 @default.
- W3196377908 hasConcept C185592680 @default.
- W3196377908 hasConcept C2775980262 @default.
- W3196377908 hasConcept C2776229602 @default.
- W3196377908 hasConcept C2776633847 @default.
- W3196377908 hasConcept C2776979534 @default.
- W3196377908 hasConcept C2777507495 @default.
- W3196377908 hasConcept C2780206646 @default.
- W3196377908 hasConcept C31903555 @default.
- W3196377908 hasConcept C529335014 @default.
- W3196377908 hasConcept C537181965 @default.
- W3196377908 hasConcept C539455810 @default.
- W3196377908 hasConcept C55493867 @default.
- W3196377908 hasConcept C61716771 @default.
- W3196377908 hasConcept C71924100 @default.
- W3196377908 hasConcept C86803240 @default.
- W3196377908 hasConcept C89423630 @default.
- W3196377908 hasConceptScore W3196377908C100544194 @default.
- W3196377908 hasConceptScore W3196377908C108797546 @default.
- W3196377908 hasConceptScore W3196377908C126322002 @default.
- W3196377908 hasConceptScore W3196377908C178790620 @default.
- W3196377908 hasConceptScore W3196377908C185592680 @default.