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- W3196388504 abstract "Exercise intolerance (EI) is the primary manifestation of chronic heart failure with preserved ejection fraction (HFpEF), the most common form of heart failure among older individuals. The recent recognition that HFpEF is likely a systemic, multiorgan disorder that shares characteristics with other common, difficult-to-treat, aging-related disorders suggests that novel insights may be gained from combining knowledge and concepts from aging and cardiovascular disease disciplines. This state-of-the-art review is based on the outcomes of a National Institute of Aging-sponsored working group meeting on aging and EI in HFpEF. We discuss aging-related and extracardiac contributors to EI in HFpEF and provide the rationale for a transdisciplinary, gero-centric approach to advance our understanding of EI in HFpEF and identify promising new therapeutic targets. We also provide a framework for prioritizing future research, including developing a uniform, comprehensive approach to phenotypic characterization of HFpEF, elucidating key geroscience targets for treatment, and conducting proof-of-concept trials to modify these targets." @default.
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- W3196388504 date "2021-09-01" @default.
- W3196388504 modified "2023-10-03" @default.
- W3196388504 title "Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction" @default.
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- W3196388504 cites W1848919668 @default.
- W3196388504 cites W1965743301 @default.
- W3196388504 cites W1970508540 @default.
- W3196388504 cites W1970911455 @default.
- W3196388504 cites W1971710084 @default.
- W3196388504 cites W1973912766 @default.
- W3196388504 cites W1990435249 @default.
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- W3196388504 cites W2000501615 @default.
- W3196388504 cites W2010583480 @default.
- W3196388504 cites W2018763145 @default.
- W3196388504 cites W2028185167 @default.
- W3196388504 cites W2031434074 @default.
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- W3196388504 cites W2093588436 @default.
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- W3196388504 cites W2102902846 @default.
- W3196388504 cites W2103538220 @default.
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- W3196388504 cites W2131250713 @default.
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- W3196388504 cites W2138638202 @default.
- W3196388504 cites W2139605571 @default.
- W3196388504 cites W2143676228 @default.
- W3196388504 cites W2145390098 @default.
- W3196388504 cites W2147846960 @default.
- W3196388504 cites W2150561868 @default.
- W3196388504 cites W2154797259 @default.
- W3196388504 cites W2156589853 @default.
- W3196388504 cites W2156791190 @default.
- W3196388504 cites W2158033629 @default.
- W3196388504 cites W2159914115 @default.
- W3196388504 cites W2160150028 @default.
- W3196388504 cites W2160684941 @default.
- W3196388504 cites W2164059021 @default.
- W3196388504 cites W2209570399 @default.
- W3196388504 cites W2214973932 @default.
- W3196388504 cites W2231944090 @default.
- W3196388504 cites W2243213947 @default.
- W3196388504 cites W2331955915 @default.
- W3196388504 cites W2336656712 @default.
- W3196388504 cites W2364050795 @default.
- W3196388504 cites W2415520736 @default.
- W3196388504 cites W2462116812 @default.