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- W3196405338 abstract "Abstract The miR-200 family of microRNAs plays a significant role in inhibiting mammary tumor growth and progression, and its members are being investigated as therapeutic targets. Additionally, if future studies can prove that miR-200s prevent mammary tumor initiation, the microRNA family could also offer a preventative strategy. Before utilizing miR-200s in a therapeutic setting, understanding how they regulate normal mammary development is necessary. No studies investigating the role of miR-200s in embryonic ductal development could be found, and only two studies examined the impact of miR-200s on pubertal ductal morphogenesis. These studies showed that miR-200s are expressed at low levels in virgin mammary glands, and elevated expression of miR-200s have the potential to impair ductal morphogenesis. In contrast to virgin mammary glands, miR-200s are expressed at high levels in mammary glands during late pregnancy and lactation. miR-200s are also found in the milk of several mammalian species, including humans. However, the relevance of miR-200s in milk remains unclear. The increase in miR-200 expression in late pregnancy and lactation suggests a role for miR-200s in the development of alveoli and/or regulating milk production. Therefore, studies investigating the consequence of miR-200 overexpression or knockdown are needed to identify the function of miR-200s in alveolar development and lactation." @default.
- W3196405338 created "2021-09-13" @default.
- W3196405338 creator A5038036447 @default.
- W3196405338 creator A5062708800 @default.
- W3196405338 date "2021-08-28" @default.
- W3196405338 modified "2023-09-27" @default.
- W3196405338 title "The miR-200 family in normal mammary gland development" @default.
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- W3196405338 doi "https://doi.org/10.1186/s12861-021-00243-7" @default.
- W3196405338 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8399786" @default.
- W3196405338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34454436" @default.
- W3196405338 hasPublicationYear "2021" @default.